Let’s talk about violence – more!

If we are to detect and prevent physical and psychological violence, we must discuss the problems intensively with our patients. Even modest investment might lead to consistent and sustainable changes. We must be determined to fulfill our role in the fight against violence.

Practical guidelines for the treatment of patellar fractures in adults

The prognosis after patellar fractures depends on the type of fracture, the force of the trauma and the number of fragments. Complications after patella fracture are not rare and potentially debilitating, and can be avoided by well-conducted treatment.

Neonatal red blood cell transfusion practices in Switzerland: national survey and review of international recommendations

Anaemia is a common problem in neonatal intensive care. The vast majority of extremely low birth weight infants (birth weight less than 1000 g) require numerous red blood cell transfusions during their neonatal period.

Treatment sequence in patients with neuroendocrine tumours: a nationwide multicentre, observational analysis of the Swiss neuroendocrine tumour registry

In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours. However, there is currently no consensus on the sequence in which these options are best used.

Outcome of Clostridioides difficile infections treated in a Swiss tertiary care hospital: an observational study

For almost three decades metronidazole has been considered the treatment of choice for Clostridioides difficile infections (CDIs), but recent publications and international guidelines have increasingly favoured other treatment regimens.

Medical end-of-life decisions in the oldest old in Switzerland

Medical end-of-life decisions include the administration of drugs to alleviate pain and other symptoms even when such treatment may hasten the patient’s death, as well as decisions to forgo potentially life-sustaining treatment.

Cochlear implants in single-sided deafness – clinical results of a Swiss multicentre study

Single-sided deafness often has a significant impact in communication skills owing to impaired sound localisation and decreased speech understanding in noise. Hearing loss is also a general risk factor for the development of tinnitus.

Cost effectiveness of pembrolizumab vs chemotherapy as first-line treatment for metastatic NSCLC that expresses high levels of PD-L1 in Switzerland

Pembrolizumab programmed death-1 (PD-1) inhibitor is indicated for treatment of patients with previously untreated metastatic NSCLC with a PD-L1 tumour proportion score (TPS) ≥50%. Its cost effectiveness for this indication has not previously been evaluated in Switzerland.

Duration of pharmacological thromboprophylaxis after outpatient endovenous laser ablation: a propensity score-matched analysis

Many centres in Europe, including several in Switzerland, use pharmacological thromboprophylaxis after thermal ablation of varicose veins. However, the optimal duration of pharmacological thromboprophylaxis is currently not defined.

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Transplantation of kidneys from deceased donors is associated with a high rate of postoperative renal dysfunction. During implantation, the kidney rewarms. This second warm ischaemia time is harmful, especially if prolonged.