New insights into the pathophysiology of inflammatory bowel disease: microbiota, epigenetics and common signalling pathways

The exact pathophysiology of inflammatory bowel disease is still unknown. However, over the years important insights allowed the development of novel therapeutic approaches that are at the threshold of introduction into clinical practice, or at least in clinical trials.

How I manage patients with anticoagulation-associated bleeding or urgent surgery

Management of anticoagulation-associated bleeding has become more challenging as the number of available drugs increases: vitamin K antagonists, unfractionated and low molecular heparin, as well as the newer direct oral anticoagulants targeting either factor Xa or thrombin.

Gamma knife radiosurgery for arteriovenous malformations: general principles and preliminary results in a Swiss cohort

Arteriovenous malformations are characterised by an abnormal connection between arteries and veins, bypassing the capillary system. Management modalities are observation, microsurgical clipping, endovascular treatment and radiosurgery.

Patient experience in primary care: association with patient, physician and practice characteristics in a fee-for-service system

Nowadays we typically use patient experience as a quality of care indicator, although this has some limitations. However, the findings are somewhat inconsistent or even conflicting.

Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): a re-evaluation of the threshold for delirium

Several instruments have been developed to screen for and detect delirium, including the Intensive Care Delirium Screening Checklist (ICDSC). However, the optimal cut-off score indicating delirium is debated.

Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland

Post-transplant lymphoproliferative disorder (PTLD) is a potentially life-threatening complication of immunosuppression and oncogenic viral infections.

Comment on: Sailer C, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy

Technical comment on: Hagner M. Open access, data capitalism and academic publishing

Reply to comment on: Sailer CO, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy

Response to Matthias Egger and Angelika Kalt