Sleep-disordered breathing may lead to excessive daytime sleepiness, fatigue, decreased alertness during the daytime and impaired cognitive functioning. Even more importantly, it is a major risk factor for future cerebro- and cardiovascular morbidity and mortality.
de Seigneux S
Tramadol has a triple action all of which are relevant in treating psychic suffering, especially suffering from the feelings of psychic “pain” that can arise from social loss. As it is short acting, has a wide therapeutic range as a weak mu-receptor agonist, has a relatively low risk for inducing neurochemical tolerance, and comparatively low risk for abuse, tramadol needs to be further evaluated for the treatment of depression.
In the REDUCE trial, 5 days of prednisone administration was shown to be noninferior to 14 days of treatment in preventing re-exacerbation of COPD. In addition, there was an inverse correlation between circulating cortisol levels and exacerbation risk during a 6-month follow-up period.
Lo Priore E,
Peripherally inserted central catheters for home administration of drugs or parenteral nutrition have undoubted benefits, but their safety has been questioned. In this study, intoduction of PICCs was supported by team surveillance of complications.
Intramuscular depot medroxyprogesterone acetate (DMPA) has been used for hormonal contraception for many years. After the introduction of a subcutaneous formulation of DPMA, a number of serious injection-site reactions were reported.
Good cardiorespiratory fitness in youth is associated with a lower risk of myocardial infarction in later life. Measurement of cardiorespiratory fitness is necessary to assess the future risk of disease and evaluate physical activity programmes.
Santos Lopes B,
De Pasquale G,
Attenhofer Jost C,
Nowadays, about 90% of children born with heart defects are expected to survive to adulthood, which has led to rapidly increasing new cohorts of adult survivors with congenital heart disease. These adults are not cured and many remain at high risk of cardiovascular complications.