Targeting the Wnt signalling pathway in cancer: prospects and perils

The Wnt pathway is not only involved in tumourigenesis and cell proliferation, but also contributes to chemoresistance and cancer stem cell propagation, responsible for tumour recurrence after therapy, metastasis and poor patient survival.

Acute effects of lysergic acid diethylamide (LSD) on resting brain function

In recent years, there has been a revival in research on hallucinogenic drugs. One of the most interesting questions is how the typical effects of LSD are represented on a neuronal level. This question was recently addressed by three clinical trials.

Imaging patterns of Pneumocystis jirovecii pneumonia in HIV-positive and renal transplant patients – a multicentre study

Pneumocystis jirovecii pneumonia (PJP) may present with a very variable pattern of clinical and radiological manifestations, depending on the immunological status of the patient.

“Alcochoix+”: controlled drinking within a structured programme – a cohort study in Switzerland

Controlled drinking as a therapy goal for problematic alcohol use is still a matter for debate, especially with regard to dependent drinkers. Furthermore, few structured controlled drinking programmes have been evaluated.

Drug prescription patterns, polypharmacy and potentially inappropriate medication in Swiss nursing homes: a descriptive analysis based on claims data

Since drug prescribing plays a major role in nursing home settings, its optimisation has become a public-health issue worldwide. To date, comprehensive data on drug utilisation in Swiss nursing homes are lacking.

Impact of staffing a surgical intermediate care unit with a critical care specialist

Intermediate care units are important in many institutions where ICUs were overbooked and occupied by some patients not requiring ICU care. Limitations are the lack of surgeons trained in critical care and demands on the time of surgical staff.

Development and validation of a multivariable risk score for prolonged length of stay in the surgical intensive care unit

Chronically critical illness (CCI) is highly relevant in intensive care units (ICUs), but the definitions in literature vary greatly. The timely detection of prolonged intensive care unit length of stay could support care planning for CCI patients.

Indications and associated factors for prescribing intravenous iron supplementation in Swiss general practice: a retrospective observational study

Intravenous iron supplementation (IVIS) is increasing in Swiss general practice. This is controversial because of higher costs and risks compared with oral iron supplementation (OIS).

Comment on: Hostettler K, et al. Bosentan for patients with steroid-resistant pulmonary sarcoidosis: a randomised controlled trial

Reply to comment by Carratù P, et al. on: Hostettler K, et al. Bosentan for patients with steroid-resistant pulmonary sarcoidosis: a randomised controlled trial