Editorial response regarding diversion of prescription and over-the-counter drugs in Switzerland

The diversion of prescription and over-the-counter medicines for recreational use is an ongoing, world-wide problem. This viewpoint article provides some possible ways to address it.

Interventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review

Pharmaceutical options for the treatment of behavioural and psychological symptoms of dementia (BPSD) are limited. This article invetigates the potential role of interventional techniques, considering the possible overlapping role of specific neurocircuits underlying BPSD.

The role of autophagy in HER2-targeted therapy

The HER2 oncogene is overexpressed in different tumour types and drugs specifically targeting it have been successfully used in cancer therapy. Resistance to these drugs ultimately occurs. In this context autophagy was reported to be upregulated.

The last decade of symptom-oriented research in emergency medicine: triage, work-up, and disposition

Symptom-oriented research has become the domain of emergency medicine research, as most other specialities have strongly focused diagnostic and prognostic research on individual disease entities.

Toxicity associated with PD-1 blockade after allogeneic haematopoietic cell transplantation

The programmed death-1 (PD-1) pathway serves as a checkpoint to limit T-cell mediated immune responses. Blocking the PD-1 receptor on T cells with monoclonal anti­bodies results in T-cell activation and proliferation and can induce a potent immuno­therapeutic antitumour effect.

Outcomes during and after the use of the wearable cardioverter-defibrillator in a tertiary-care and a regional hospital in Switzerland

Careful patient selection for wearable cardioverter-defibrillator (WCD) use is crucial, but unfortunately very little information from randomised controlled trials is available to guide clinical decision-making.

Describing adverse events in medical inpatients using the Global Trigger Tool

Improving patient safety in hospitals demands effective and reliable monitoring of adverse events (AEs). The most common method of assessing AEs is retrospective chart review; the Global Trigger Tool is a promising chart review method.

Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

Neuregulin-4 is a cytokine with many functions primarily produced by fat tissue. It is associated with body fat mass, insulin resistance, impaired glucose metabolism, obesity, non-alcoholic fatty liver disease, type 2 diabetes mellitus and metabolic syndrome.

Comment on: Novosel D. Setting as informed consent in psychotherapy. Swiss Med Wkly.2019;149:w20028

Reply to comment by Poppe C on: Novosel D. Setting as informed consent in psychotherapy. Swiss Med Wkly.2019;149:w20028