Original article
Vol. 154 No. 4 (2024)
Incidence and outcomes of emergency department patients requiring emergency general surgery: a 5-year retrospective cohort study
- Christophe A. Fehlmann
- Monica Taljaard
- Daniel I. McIsaac
- Laurent Suppan
- Elisabeth Andereggen
- Arnaud Dupuis
- Frederic Rouyer
- Debra Eagles
- Jeffrey J. Perry
Summary
AIMS: Patients undergoing emergency general surgery are at high risk of complications and death. Our objectives were to estimate the incidence of emergency general surgery in a Swiss University Hospital, to describe the characteristics and outcomes of patients undergoing such procedures, and to study the impact of age on clinical outcomes.
METHODS: This was a retrospective cohort study of adult patients who visited the emergency department (ED) of Geneva University Hospitals between January 2015 and December 2019. Routinely collected data were extracted from electronic medical records. The primary outcome was the incidence of emergency general surgery among patients visiting the emergency department, defined as general surgery within three days of emergency department admission. We also assessed demographic characteristics, mortality, intensive care unit admission and patient disposition. Multivariable log-binomial regression was used to study the associations of age with intensive care unit (ICU) admission, one-year mortality and dependence at discharge. Age was modelled as a continuous variable using restricted cubic splines and we compared older patients (75th percentile) with younger patients (25th percentile).
RESULTS: Between January 2015 and December 2019, a total of 310,914 emergency department visits met our inclusion criteria. Among them, 3592 patients underwent emergency general surgery within 3 days of emergency department admission, yielding an annual incidence of 116 events per 10,000 emergency department visits (95% CI: 112–119), with a higher incidence in females and young patients. Overall, 5.3% of patients were admitted to ICU, 7.8% were dependent on rehabilitation or assisted living at discharge and 4.8% were dead after one year. Older patients had a higher risk of ICU admission (adjusted risk ratio (aRR) 2.9 [1.5–5.4]), dependence at discharge (aRR 15.3 [5.5–42.4]) and one-year mortality (aRR 5.4 [2.2–13.4]).
CONCLUSION: Emergency department visits resulting in emergency general surgery are frequent, but their incidence decreases with patient age. Mortality, ICU admission and dependence at discharge following emergency general surgery are more frequent in older patients. Taking into account the increased risk for older patients, a shared process is appropriate for making more informed decisions about their options for care.
References
- Shafi S, Aboutanos MB, Agarwal S Jr, Brown CV, Crandall M, Feliciano DV, et al.; AAST Committee on Severity Assessment and Patient Outcomes. Emergency general surgery: definition and estimated burden of disease. J Trauma Acute Care Surg. 2013 Apr;74(4):1092–7. 10.1097/TA.0b013e31827e1bc7
DOI: https://doi.org/10.1097/TA.0b013e31827e1bc7
- To KB, Kamdar NS, Patil P, Collins SD, Seese E, Krapohl GL, et al.; Michigan Surgical Quality Collaborative (MSQC) Emergency General Surgery Study Group and the MSQC Research Advisory Group. Acute Care Surgery Model and Outcomes in Emergency General Surgery. J Am Coll Surg. 2019 Jan;228(1):21–28.e7. 10.1016/j.jamcollsurg.2018.07.664
DOI: https://doi.org/10.1016/j.jamcollsurg.2018.07.664
- Havens JM, Peetz AB, Do WS, Cooper Z, Kelly E, Askari R, et al. The excess morbidity and mortality of emergency general surgery. J Trauma Acute Care Surg. 2015 Feb;78(2):306–11. 10.1097/TA.0000000000000517
DOI: https://doi.org/10.1097/TA.0000000000000517
- OECD. Health Care Resources 2019. [cited 2020; Available from: https://stats.oecd.org/index.aspx?DataSetCode=HEALTH_REAC#
- Fowler AJ, Abbott TE, Prowle J, Pearse RM. Age of patients undergoing surgery. Br J Surg. 2019 Jul;106(8):1012–8. 10.1002/bjs.11148
DOI: https://doi.org/10.1002/bjs.11148
- Al-Temimi MH, Griffee M, Enniss TM, Preston R, Vargo D, Overton S, et al. When is death inevitable after emergency laparotomy? Analysis of the American College of Surgeons National Surgical Quality Improvement Program database. J Am Coll Surg. 2012 Oct;215(4):503–11. 10.1016/j.jamcollsurg.2012.06.004
DOI: https://doi.org/10.1016/j.jamcollsurg.2012.06.004
- von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007 Oct;370(9596):1453–7. 10.1016/S0140-6736(07)61602-X
DOI: https://doi.org/10.1016/S0140-6736(07)61602-X
- Feeney T, Castillo-Angeles M, Scott JW, Nitzschke SL, Salim A, Haider AH, et al. The independent effect of emergency general surgery on outcomes varies depending on case type: A NSQIP outcomes study. Am J Surg. 2018 Nov;216(5):856–62. 10.1016/j.amjsurg.2018.03.006
DOI: https://doi.org/10.1016/j.amjsurg.2018.03.006
- Rutschmann OT, Kossovsky M, Geissbühler A, Perneger TV, Vermeulen B, Simon J, et al. Interactive triage simulator revealed important variability in both process and outcome of emergency triage. J Clin Epidemiol. 2006 Jun;59(6):615–21. 10.1016/j.jclinepi.2005.11.003
DOI: https://doi.org/10.1016/j.jclinepi.2005.11.003
- Bloom DE, Mitgang E, Osher B. Demography of global ageing, in Oxford Textbook of Geriatric Medicine, J.-P. Michel, et al., Editors. 2017, Oxford University Press. p. 0. 10.1093/med/9780198701590.003.0001
DOI: https://doi.org/10.1093/med/9780198701590.003.0001
- Parmar KL, et al. Frailty in Older Patients Undergoing Emergency Laparotomy: Results From the UK Observational Emergency Laparotomy and Frailty (ELF) Study. Ann Surg. 2019.
DOI: https://doi.org/10.1097/SLA.0000000000003402
- Harrell FE. General Aspects of Fitting Regression Models, in Regression Modeling Strategies. 2015, Springer International Publishing. p. 13-44. 10.1007/978-3-319-19425-7_2
DOI: https://doi.org/10.1007/978-3-319-19425-7_2
- Knol MJ, Le Cessie S, Algra A, Vandenbroucke JP, Groenwold RH. Overestimation of risk ratios by odds ratios in trials and cohort studies: alternatives to logistic regression. CMAJ. 2012 May;184(8):895–9. 10.1503/cmaj.101715
DOI: https://doi.org/10.1503/cmaj.101715
- Pendyal A, Rothenberg C, Scofi JE, Krumholz HM, Safdar B, Dreyer RP, et al. National Trends in Emergency Department Care Processes for Acute Myocardial Infarction in the United States, 2005 to 2015. J Am Heart Assoc. 2020 Oct;9(20):e017208. 10.1161/JAHA.120.017208
DOI: https://doi.org/10.1161/JAHA.120.017208
- Kline JA, Garrett JS, Sarmiento EJ, Strachan CC, Courtney DM. Over-Testing for Suspected Pulmonary Embolism in American Emergency Departments: The Continuing Epidemic. Circ Cardiovasc Qual Outcomes. 2020 Jan;13(1):e005753. 10.1161/CIRCOUTCOMES.119.005753
DOI: https://doi.org/10.1161/CIRCOUTCOMES.119.005753
- Ukkonen M, Jämsen E, Zeitlin R, Pauniaho SL. Emergency department visits in older patients: a population-based survey. BMC Emerg Med. 2019 Feb;19(1):20. 10.1186/s12873-019-0236-3
DOI: https://doi.org/10.1186/s12873-019-0236-3
- Hutchings A, Moler Zapata S, O’Neill S, Smart N, Cromwell D, Hinchliffe R, et al. Variation in the rates of emergency surgery amongst emergency admissions to hospital for common acute conditions. BJS Open. 2021 Nov;5(6):zrab094. 10.1093/bjsopen/zrab094
DOI: https://doi.org/10.1093/bjsopen/zrab094
- Chana P, Joy M, Casey N, Chang D, Burns EM, Arora S, et al. Cohort analysis of outcomes in 69 490 emergency general surgical admissions across an international benchmarking collaborative. BMJ Open. 2017 Mar;7(3):e014484. 10.1136/bmjopen-2016-014484
DOI: https://doi.org/10.1136/bmjopen-2016-014484
- Sangji NF, Bohnen JD, Ramly EP, Yeh DD, King DR, DeMoya M, et al. Derivation and validation of a novel Emergency Surgery Acuity Score (ESAS). J Trauma Acute Care Surg. 2016 Aug;81(2):213–20. 10.1097/TA.0000000000001059
DOI: https://doi.org/10.1097/TA.0000000000001059
- Ozdemir BA, Sinha S, Karthikesalingam A, Poloniecki JD, Pearse RM, Grocott MP, et al. Mortality of emergency general surgical patients and associations with hospital structures and processes. Br J Anaesth. 2016 Jan;116(1):54–62. 10.1093/bja/aev372
DOI: https://doi.org/10.1093/bja/aev372
- Lavanchy JL, Holzgang MM, Haltmeier T, Candinas D, Schnüriger B. Outcomes of emergency abdominal surgery in octogenarians: A single-center analysis. Am J Surg. 2019 Aug;218(2):248–54. 10.1016/j.amjsurg.2018.11.023
DOI: https://doi.org/10.1016/j.amjsurg.2018.11.023
- Giger UF, Michel JM, Opitz I, Th Inderbitzin D, Kocher T, Krähenbühl L; Swiss Association of Laparoscopic and Thoracoscopic Surgery (SALTS) Study Group. Risk factors for perioperative complications in patients undergoing laparoscopic cholecystectomy: analysis of 22,953 consecutive cases from the Swiss Association of Laparoscopic and Thoracoscopic Surgery database. J Am Coll Surg. 2006 Nov;203(5):723–8. 10.1016/j.jamcollsurg.2006.07.018
DOI: https://doi.org/10.1016/j.jamcollsurg.2006.07.018
- Wohlgemut JM, Ramsay G, Bekheit M, Scott NW, Watson AJ, Jansen JO. Emergency general surgery: impact of distance and rurality on mortality. BJS Open. 2022 Mar;6(2):zrac032. 10.1093/bjsopen/zrac032
DOI: https://doi.org/10.1093/bjsopen/zrac032
- Magyar CT, Haltmeier T, Dubuis JB, Osterwalder A, Winterhalder S, Candinas D, et al. Performance of quick sequential organ failure assessment and modified age disease adjusted qadSOFA for the prediction of outcomes in emergency general surgery patients. J Trauma Acute Care Surg. 2022 Oct;93(4):558–65. 10.1097/TA.0000000000003742
DOI: https://doi.org/10.1097/TA.0000000000003742
- Castillo-Angeles M, Cooper Z, Jarman MP, Sturgeon D, Salim A, Havens JM. Association of Frailty With Morbidity and Mortality in Emergency General Surgery By Procedural Risk Level. JAMA Surg. 2020. 10.1001/jamasurg.2020.5397
DOI: https://doi.org/10.1001/jamasurg.2020.5397
- Paredes AZ, Malik AT, Cluse M, Strassels SA, Santry HP, Eiferman D, et al. Discharge disposition to skilled nursing facility after emergent general surgery predicts a poor prognosis. Surgery. 2019 Oct;166(4):489–95. 10.1016/j.surg.2019.04.034
DOI: https://doi.org/10.1016/j.surg.2019.04.034
- Fehlmann C, Louis Simonet M, Reny JL, Stirnemann J, Blondon K. Associations between early handoffs, length of stay and complications in internal medicine wards: A retrospective study. Eur J Intern Med. 2019 Sep;67:77–83. 10.1016/j.ejim.2019.07.003
DOI: https://doi.org/10.1016/j.ejim.2019.07.003
- Baimas-George M, Yelverton S, Ross SW, Rozario N, Matthews BD, Reinke CE. Palliative Care in Emergency General Surgery Patients: Reduced Inpatient Mortality And Increased Discharge to Hospice. Am Surg. 2021 Jul;87(7):1087–92. 10.1177/0003134820956942
DOI: https://doi.org/10.1177/0003134820956942
- Rubin EB, Buehler AE, Halpern SD. States Worse Than Death Among Hospitalized Patients With Serious Illnesses. JAMA Intern Med. 2016 Oct;176(10):1557–9. 10.1001/jamainternmed.2016.4362
DOI: https://doi.org/10.1001/jamainternmed.2016.4362