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Original article

Vol. 150 No. 4142 (2020)

Incidence of glomerulonephritis in the western part of Switzerland over the last decade

DOI
https://doi.org/10.4414/smw.2020.20353
Cite this as:
Swiss Med Wkly. 2020;150:w20353
Published
06.10.2020

Summary

BACKGROUND

Glomerulonephritis is a rare yet serious group of diseases with a high risk of progression to end-stage renal disease. For optimal healthcare planning, detailed epidemiological and demographic data are essential. Despite their clinical relevance, these data are largely lacking in Switzerland.

OBJECTIVE

The objective of this study was to assess the incidence of the different forms of glomerulonephritis in the western part of Switzerland and its changes over the last 10 years, compared with international data.

METHODS

We listed all renal biopsy reports analysed between 2007 and 2016 at the University hospital of Lausanne, the renal pathology reference centre of all hospitals in the cantons of Vaud, Fribourg, Valais and Neuchâtel. Biopsies with a first diagnosis of primary glomerulonephritis were included in the analysis. The incidence was calculated as the number of patients newly diagnosed with glomerulonephritis divided by the number of inhabitants of all the above-mentioned cantons during the year under review, as retrieved from the federal statistical office of Switzerland.

RESULTS

We collected biopsy reports from 864 patients between 2007 and 2016; 168 biopsies met the inclusion criteria. The most common primary glomerulonephritis was IgA nephropathy at 32.7% of cases, followed by lupus nephritis (29.8%) and pauci-immune glomerulonephritis (11.9%). Overall, the mean incidence of glomerulonephritis was 1.3/100,000/year. Between 2007 and 2016, the incidence of all glomerulonephritis taken together remained stable. The same was true for the incidence of IgA nephropathy, lupus nephritis and pauci-immune glomerulonephritis. In contrast, we observed a trend towards higher creatinine levels, proteinuria and degree of interstitial fibrosis at diagnosis.

CONCLUSION

The incidence of glomerulonephritis in the western part of Switzerland was low and remained stable over time, in line with European data.

References

  1. Halfon M, Pruijm M. Glomérulonéphrites. Swiss Med Forum. 2017;17(13):298–305. doi:.https://doi.org/10.4414/smf.2017.02891
  2. McGrogan A, Franssen CF, de Vries CS. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrol Dial Transplant. 2011;26(2):414–30. doi:.https://doi.org/10.1093/ndt/gfq665
  3. UK Renal Registry. UK Renal Registry 21st Annual Report. Data to 31 December 2017. Bristol, UK: 2019. Available from https://www.renalreg.org/publications-reports/.
  4. Saran R, Li Y, Robinson B, Abbott KC, Agodoa LY, Ayanian J, et al. US Renal Data System 2015 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2016;67(3, Suppl 1):S1–305. doi:.https://doi.org/10.1053/j.ajkd.2015.12.014
  5. Sim JJ, Bhandari SK, Batech M, Hever A, Harrison TN, Shu YH, et al. End-Stage Renal Disease and Mortality Outcomes Across Different Glomerulonephropathies in a Large Diverse US Population. Mayo Clin Proc. 2018;93(2):167–78. doi:.https://doi.org/10.1016/j.mayocp.2017.10.021
  6. Madaio MP, Harrington JT. The diagnosis of glomerular diseases: acute glomerulonephritis and the nephrotic syndrome. Arch Intern Med. 2001;161(1):25–34. doi:.https://doi.org/10.1001/archinte.161.1.25
  7. Vivarelli M, Massella L, Ruggiero B, Emma F. Minimal Change Disease. Clin J Am Soc Nephrol. 2017;12(2):332–45. doi:.https://doi.org/10.2215/CJN.05000516
  8. Rosenberg AZ, Kopp JB. Focal Segmental Glomerulosclerosis. Clin J Am Soc Nephrol. 2017;12(3):502–17. doi:.https://doi.org/10.2215/CJN.05960616
  9. Rodrigues JC, Haas M, Reich HN. IgA Nephropathy. Clin J Am Soc Nephrol. 2017;12(4):677–86. doi:.https://doi.org/10.2215/CJN.07420716
  10. Wasserstein AG. Membranous glomerulonephritis. J Am Soc Nephrol. 1997;8(4):664–74.
  11. Fakhouri F. Approche clinique des glomérulonéphrites membranoprolifératives primitives [Clinical approach to primary membranoproliferative glomerulonephritis]. Nephrol Ther. 2016;12(Suppl 1):S65–9. doi:.https://doi.org/10.1016/j.nephro.2016.01.008
  12. Syed R, Rehman A, Valecha G, El-Sayegh S. Pauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis. BioMed Res Int. 2015;2015:402826. doi:.https://doi.org/10.1155/2015/402826
  13. McAdoo SP, Pusey CD. Anti-Glomerular Basement Membrane Disease. Clin J Am Soc Nephrol. 2017;12(7):1162–72. doi:.https://doi.org/10.2215/CJN.01380217
  14. Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. Clin J Am Soc Nephrol. 2017;12(5):825–35. doi:.https://doi.org/10.2215/CJN.05780616
  15. Schwartz MM, Korbet SM, Lewis EJ. Immunotactoid glomerulopathy. J Am Soc Nephrol. 2002;13(5):1390–7. doi:.https://doi.org/10.1097/01.ASN.0000013397.06964.19
  16. Hanko JB, Mullan RN, O’Rourke DM, McNamee PT, Maxwell AP, Courtney AE. The changing pattern of adult primary glomerular disease. Nephrol Dial Transplant. 2009;24(10):3050–4. doi:.https://doi.org/10.1093/ndt/gfp254
  17. Zaza G, Bernich P, Lupo A ; ‘Triveneto’ Register of Renal Biopsies (TVRRB). Incidence of primary glomerulonephritis in a large North-Eastern Italian area: a 13-year renal biopsy study. Nephrol Dial Transplant. 2013;28(2):367–72. doi:.https://doi.org/10.1093/ndt/gfs437
  18. Wirta O, Mustonen J, Helin H, Pasternack A. Incidence of biopsy-proven glomerulonephritis. Nephrol Dial Transplant. 2008;23(1):193–200. doi:.https://doi.org/10.1093/ndt/gfm564
  19. Stratta P, Segoloni GP, Canavese C, Sandri L, Mazzucco G, Roccatello D, et al. Incidence of biopsy-proven primary glomerulonephritis in an Italian province. Am J Kidney Dis. 1996;27(5):631–9. doi:.https://doi.org/10.1016/S0272-6386(96)90096-7
  20. Schena FP, Nistor I. Epidemiology of IgA Nephropathy: A Global Perspective. Semin Nephrol. 2018;38(5):435–42. doi:.https://doi.org/10.1016/j.semnephrol.2018.05.013
  21. Briganti EM, Dowling J, Finlay M, Hill PA, Jones CL, Kincaid-Smith PS, et al. The incidence of biopsy-proven glomerulonephritis in Australia. Nephrol Dial Transplant. 2001;16(7):1364–7. doi:.https://doi.org/10.1093/ndt/16.7.1364
  22. Golay V, Trivedi M, Abraham A, Roychowdhary A, Pandey R. The spectrum of glomerular diseases in a single center: A clinicopathological correlation. Indian J Nephrol. 2013;23(3):168–75. doi:.https://doi.org/10.4103/0971-4065.111833
  23. Okpechi IG, Ameh OI, Bello AK, Ronco P, Swanepoel CR, Kengne AP. Epidemiology of Histologically Proven Glomerulonephritis in Africa: A Systematic Review and Meta-Analysis. PLoS One. 2016;11(3):e0152203. doi:.https://doi.org/10.1371/journal.pone.0152203
  24. Machado SGMR, Quadros T, Watanabe Y, Aquino CF, Otoni A, Pinto SW. Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology. Rev Assoc Med Bras (1992). 2019;65(3):441–5. doi:.https://doi.org/10.1590/1806-9282.65.3.441
  25. Ali AA, Sharif DA, Almukhtar SE, Abd KH, Saleem ZSM, Hughson MD. Incidence of glomerulonephritis and non-diabetic end-stage renal disease in a developing middle-east region near armed conflict. BMC Nephrol. 2018;19(1):257. doi:.https://doi.org/10.1186/s12882-018-1062-7
  26. AlFaadhel T, Alsuwaida A, Alsaad K, Almezaini L, Ahmed N, AlHamad MY, et al. Prevalence and 20-year epidemiological trends of glomerular diseases in the adult Saudi population: a multicenter study. Ann Saudi Med. 2019;39(3):155–61. doi:.https://doi.org/10.5144/0256-4947.2019.155
  27. Nie P, Chen R, Luo M, Dong C, Chen L, Liu J, et al. Clinical and Pathological Analysis of 4910 Patients Who Received Renal Biopsies at a Single Center in Northeast China. BioMed Res Int. 2019;2019:6869179. doi:.https://doi.org/10.1155/2019/6869179
  28. USRDS annual data report. Epidemiology of kidney disease in the United States, in National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Bethesda, MD: United States Renal Data System; 2019

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