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Review article: Biomedical intelligence

Vol. 144 No. 5152 (2014)

Oxidised phospholipids as biomarkers in human disease

  • Maria Philippova
  • Therese Resink
  • Paul Erne
  • Valerie Bochkov
DOI
https://doi.org/10.4414/smw.2014.14037
Cite this as:
Swiss Med Wkly. 2014;144:w14037
Published
15.12.2014

Abstract

Oxidised phospholipids (OxPLs) are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety of biological effects on diverse cell types in vitro and in vivo and are thought to play a role in the development of several chronic diseases including atherosclerosis, a classical lipid-associated and inflammatory disorder. OxPLs are recognised as culprit molecular components responsible for the pathophysiological actions of oxidised low-density lipoproteins. There is growing interest in the potential use of OxPLs as biomarkers of human pathologies. Here we offer a brief overview of current detection methods and knowledge on relationships between levels of circulating OxPLs and disease progression, with particular emphasis on cardiovascular disease.

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