Vol. 142 No. 4748 (2012)
Vitamin D levels and associated factors: a population-based study in Switzerland
- Idris Guessous
- Vincent Dudler
- Nicolas Glatz
- Jean-Marc Theler
- Otmar Zoller
- Fred Paccaud
- Michel Burnier
- Murielle Bochud
QUESTIONS UNDER STUDY: To update the prevalence of vitamin D insufficiency and to identify factors associated with vitamin D status in the Swiss adult population.
METHODS: Data from the 2010–2011 Swiss Study on Salt intake, a population-based study in the Swiss population, was used. Vitamin D concentration in serum was measured by liquid chromatography- tandem mass spectrometry. Major factors that influence vitamin D levels were taken into account. Survey statistical procedures were used to estimate means and prevalences of vitamin D levels and status. Monthly-specific tertiles of vitamin D and ordinal logistic regression were used to determine the associations of covariates of interest with vitamin D status.
RESULTS: The prevalences of vitamin D insufficiency (serum 25-hydroxyvitamin D: 20–29.9 ng/ml) and deficiency (<20 ng/ml) were the highest in the January-March period; 26.4% (95%CI: 21.6–31.7) and 61.6% (95%CI: 56.0–67.0), respectively. In the same period, more than 9 of ten men were vitamin D insufficient or deficient. Each unit increase of Body Mass Index was associated with an 8% decreased likelihood of being in a higher vitamin D tertiles. Oral contraceptive, altitude, urinary excretion of calcium, use of vitamin D supplement or treatment, high wine consumption, physical activity were associated with vitamin D tertiles. Compared to the French-speaking region, the Italian-speaking region was independantly associated with a higher likelihood of being in higher vitamin D tertiles (OR: 1.66, 95%CI: 1.14–2.43).
CONCLUSIONS: Low levels of vitamin D are common among Swiss adults, in particular during winter months and outside the Italian-speaking region.
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