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Original article

Vol. 142 No. 3132 (2012)

Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma

  • Lorenz Kuske
  • Armand Mensen
  • Beat Müllhaupt
  • Francesco Negro
  • David Semela
  • Darius Moradpour
  • Pierre Jean Malé
  • Markus H Heim
  • Raffaele Malinverni
  • Andreas Cerny
  • Jean-Francois Dufour
DOI
https://doi.org/10.4414/smw.2012.13651
Cite this as:
Swiss Med Wkly. 2012;142:w13651
Published
29.07.2012

Abstract

BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is the most frequent form of primary liver cancer and chronic infection with hepatitis C virus is one of the main risk factors for HCC. This study analyses the characteristics of the patients with chronic hepatitis C participating in the Swiss Hepatitis C Cohort Study who developed HCC.

METHODS: Analysis of the database of the Swiss Hepatitis C Cohort Study, a multicentre study that is being carried out in eight major Swiss hospitals since the year 2000. Patients with chronic hepatitis C and HCC were regrouped and compared to the patients without HCC.

RESULTS: Among the 3,390 patients of the cohort, 130 developed an HCC. Age was one of the determining factors. Cirrhosis and its complications ascites and porto-systemic encephalopathy were associated with HCC. Males presented a higher risk for HCC than females. Alcohol consumption was associated with HCC. Diabetes mellitus was an important risk factor, especially in patients with low fibrosis. Patients with Hepatitis C genotype 2 had significantly less HCC than patients with other genotypes. A low socioeconomic status (income, education, profession) was associated with HCC.

CONCLUSIONS: Beside the expected characteristics (age, gender, cirrhosis, alcohol), these data stress the role of diabetes mellitus and reveal the importance of low socioeconomic status as a risk factor for HCC in Swiss patients infected with hepatitis C virus. This vulnerable population should be closely monitored.

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