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DOI:
https://doi.org/10.57187/5009

Original article

Vol. 156 No. 10 (2026)

Communication and relational factors supporting the willingness to initiate palliative care in advanced cancer: a factorial vignette survey

Cite this as:
Swiss Med Wkly. 2026;156:5009
Published
22.10.2026

Summary

BACKGROUND AND STUDY AIMS: Guidelines recommend early initiation of palliative care alongside anticancer therapy. However, ongoing treatment is often associated with delayed referral to palliative care. Factors that positively influence the initiation of palliative care have been studied in the past, but there is a gap in research regarding the individual degree of influence these factors have on the willingness to initiate palliative care. Therefore, we explored the degree of influence of 11 different factors on willingness to initiate palliative care, focusing on communicational and relational aspects.

METHODS: We conducted a factorial survey among 1572 members of the Swiss public. Participants were presented with vignettes designed to explore willingness to start palliative care. A response format ranging from -5 to +5 was provided. Vignettes were analysed using mixed-effects regression models.

RESULTS: The physician having enough time for the conversation, the provision of detailed and understandable information, and an expression about continuity of care led to the strongest increase in willingness. There was also an increase in willingness when treatment recommendations were based on experience and patient preferences, as well as with self-disclosure, the expression of sadness by the physician, work experience, a prior patient-physician relationship and older patient age.

CONCLUSION: This study offers insight into the decision-making process regarding the initiation of palliative care at an advanced stage of disease progression. Supportive communication practices and expressions of understanding for the other led to a higher willingness to start palliative care. These aspects should be considered in discussions about advanced cancer in clinical practice, as well as emphasised in medical education.

References

  1. 1. Earle CC, Landrum MB, Souza JM, Neville BA, Weeks JC, Ayanian JZ. Aggressiveness of Cancer Care Near the End of Life: Is It a Quality-of-Care Issue?. Journal of Clinical Oncology. 2008 Aug 10;26(23):3860-3866. doi:10.1200/JCO.2007.15.8253
  2. 2. Baena-Cañada JM, Campini Bermejo A, Gámez Casado S, Rodríguez Pérez L, Quílez Cutillas A, Calvete Candenas J, et al. Experiences with Prescribing Large Quantities of Systemic Anticancer Therapy Near Death. Journal of Palliative Medicine. 2019 Dec 1;22(12):1515-1521. doi:10.1089/jpm.2019.0017
  3. 3. Akhlaghi E, Lehto RH, Torabikhah M, Sharif Nia H, Taheri A, Zaboli E, et al. Chemotherapy use and quality of life in cancer patients at the end of life: an integrative review. Health and Quality of Life Outcomes. 2020 Dec;18(1):332. doi:10.1186/s12955-020-01580-0
  4. 4. Frigeri M, De Dosso S, Castillo-Fernandez O, Feuerlein K, Neuenschwander H, Saletti P. Chemotherapy in patients with advanced pancreatic cancer: too close to death?. Supportive Care in Cancer. 2013 Jan;21(1):157-163. doi:10.1007/s00520-012-1505-9
  5. 5. Braga S, Miranda A, Fonseca R, Passos‐Coelho JL, Fernandes A, Costa JD, et al. The aggressiveness of cancer care in the last three months of life: a retrospective single centre analysis. Psycho-Oncology. 2007 Sep;16(9):863-868. doi:10.1002/pon.1140
  6. 6. Emanuel EJ, Young-Xu Y, Levinsky NG, Gazelle G, Saynina O, Ash AS. Chemotherapy Use among Medicare Beneficiaries at the End of Life. Annals of Internal Medicine. 2003 Apr 15;138(8):639-643. doi:10.7326/0003-4819-138-8-200304150-00011
  7. 7. Wright AA, Zhang B, Keating NL, Weeks JC, Prigerson HG. Associations between palliative chemotherapy and adult cancer patients' end of life care and place of death: prospective cohort study. BMJ. 2014 Mar 4;348(mar04 4):g1219-g1219. doi:10.1136/bmj.g1219
  8. 8. Glisch C, Saeidzadeh S, Snyders T, Gilbertson-White S, Hagiwara Y, Lyckholm L. Immune Checkpoint Inhibitor Use Near the End of Life: A Single-Center Retrospective Study. Journal of Palliative Medicine. 2020 Jul 1;23(7):977-979. doi:10.1089/jpm.2019.0383
  9. 9. Auclair J, Sanchez S, Chrusciel J, Hannetel L, Frasca M, Economos G, et al. Duration of palliative care involvement and immunotherapy treatment near the end of life among patients with cancer who died in-hospital. Supportive Care in Cancer. 2022 Jun;30(6):4997-5006. doi:10.1007/s00520-022-06901-1
  10. 10. Bakitas M, Lyons KD, Hegel MT, Balan S, Brokaw FC, Seville J, et al. Effects of a Palliative Care Intervention on Clinical Outcomes in Patients With Advanced Cancer. JAMA. 2009 Aug 19;302(7):741. doi:10.1001/jama.2009.1198
  11. 11. Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG. End-of-Life Discussions, Goal Attainment, and Distress at the End of Life: Predictors and Outcomes of Receipt of Care Consistent With Preferences. Journal of Clinical Oncology. 2010 Mar 1;28(7):1203-1208. doi:10.1200/JCO.2009.25.4672
  12. 12. Romano AM, Gade KE, Nielsen G, Havard R, Harrison JH, Barclay J, et al. Early Palliative Care Reduces End-of-Life Intensive Care Unit (ICU) Use but Not ICU Course in Patients with Advanced Cancer. The Oncologist. 2017 Mar 1;22(3):318-323. doi:10.1634/theoncologist.2016-0227
  13. 13. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer. New England Journal of Medicine. 2010 Aug 19;363(8):733-742. doi:10.1056/NEJMoa1000678
  14. 14. Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update. Journal of Clinical Oncology. 2017 Jan 1;35(1):96-112. doi:10.1200/JCO.2016.70.1474
  15. 15. Jordan K, Aapro M, Kaasa S, Ripamonti CI, Scotté F, Strasser F, et al. European Society for Medical Oncology (ESMO) position paper on supportive and palliative care. Annals of Oncology. 2018 Jan;29(1):36-43. doi:10.1093/annonc/mdx757
  16. 16. Nationale Leitlinien Palliative Care [Internet]. Available from: https://www.bag.admin.ch/de/nationale-leitlinien-palliative-care
  17. 17. Choosing Wisely - ASCO [Internet]. Available from: https://www.asco.org/news-initiatives/current-initiatives/cancer-care-initiatives/value-cancer-care/choosing-wisely
  18. 18. Crawford GB, Dzierżanowski T, Hauser K, Larkin P, Luque-Blanco AI, Murphy I, et al. Care of the adult cancer patient at the end of life: ESMO Clinical Practice Guidelines. ESMO Open. 2021 Aug;6(4):100225. doi:10.1016/j.esmoop.2021.100225
  19. 19. Cherny NI, Nortjé N, Kelly R, Zimmermann C, Jordan K, Kreye G, et al. A taxonomy of the factors contributing to the overtreatment of cancer patients at the end of life. What is the problem? Why does it happen? How can it be addressed?. ESMO Open. 2025 Jan;10(1):104099. doi:10.1016/j.esmoop.2024.104099
  20. 20. DuMontier C, Loh KP, Bain PA, Silliman RA, Hshieh T, Abel GA, et al. Defining Undertreatment and Overtreatment in Older Adults With Cancer: A Scoping Literature Review. Journal of Clinical Oncology. 2020 Aug 1;38(22):2558-2569. doi:10.1200/JCO.19.02809
  21. 21. Wilkerson DH, Santos JL, Tan X, Gomez TH. Too Much Too Late? Chemotherapy Administration at the End of Life: A Retrospective Observational Study. American Journal of Hospice and Palliative Medicine®. 2021 Oct;38(10):1182-1188. doi:10.1177/1049909120966619
  22. 22. Canavan ME, Wang X, Ascha MS, Miksad RA, Calip GS, Gross CP, et al. Systemic Anticancer Therapy at the End of Life—Changes in Usage Pattern in the Immunotherapy Era. JAMA Oncology. 2022 Dec 1;8(12):1847. doi:10.1001/jamaoncol.2022.4666
  23. 23. Matter-Walstra KW, Achermann R, Rapold R, Klingbiel D, Bordoni A, Dehler S, et al. Cancer-Related Therapies at the End of Life in Hospitalized Cancer Patients from Four Swiss Cantons: SAKK 89/09. Oncology. 2015;88(1):18-27. doi:10.1159/000367629
  24. 24. Zdenkowski N, Cavenagh J, Ku YC, Bisquera A, Bonaventura A. Administration of chemotherapy with palliative intent in the last 30 days of life: the balance between palliation and chemotherapy. Internal Medicine Journal. 2013 Nov;43(11):1191-1198. doi:10.1111/imj.12245
  25. 25. Morita T, Akechi T, Ikenaga M, Kizawa Y, Kohara H, Mukaiyama T, et al. Late Referrals to Specialized Palliative Care Service in Japan. Journal of Clinical Oncology. 2005 Apr 20;23(12):2637-2644. doi:10.1200/JCO.2005.12.107
  26. 26. Vinant P, Joffin I, Serresse L, Grabar S, Jaulmes H, Daoud M, et al. Integration and activity of hospital-based palliative care consultation teams: the INSIGHT multicentric cohort study. BMC Palliative Care. 2017 Dec;16(1):36. doi:10.1186/s12904-017-0209-9
  27. 27. Traeger L, Rapoport C, Wright E, El-Jawahri A, Greer JA, Park ER, et al. Nature of Discussions about Systemic Therapy Discontinuation or Hospice among Patients, Families, and Palliative Care Clinicians during Care for Incurable Cancer: A Qualitative Study. Journal of Palliative Medicine. 2020 Apr 1;23(4):542-547. doi:10.1089/jpm.2019.0402
  28. 28. Brom L, Onwuteaka-Philipsen BD, Widdershoven GAM, Pasman HRW. Mechanisms that contribute to the tendency to continue chemotherapy in patients with advanced cancer. Qualitative observations in the clinical setting. Supportive Care in Cancer. 2016 Mar;24(3):1317-1325. doi:10.1007/s00520-015-2910-7
  29. 29. Puts MTE, Tapscott B, Fitch M, Howell D, Monette J, Wan-Chow-Wah D, et al. A systematic review of factors influencing older adults’ decision to accept or decline cancer treatment. Cancer Treatment Reviews. 2015 Feb;41(2):197-215. doi:10.1016/j.ctrv.2014.12.010
  30. 30. Baile WF, Glober GA, Lenzi R, Beale EA, Kudelka AP. Discussing disease progression and end-of-life decisions. Oncol Williston Park N. 1999 Jul;13(7):1021–31; discussion 1031-1036, 1038.
  31. 31. Schofield P, Carey M, Love A, Nehill C, Wein S. ‘Would you like to talk about your future treatment options?’ discussing the transition from curative cancer treatment to palliative care. Palliative Medicine. 2006 Jun;20(4):397-406. doi:10.1191/0269216306pm1156oa
  32. 32. Alesi E, Bobb B, Smith TJ. Guiding Patients Facing Decisions about “Futile” Chemotherapy. The Journal of Supportive Oncology. 2011 Sep;9(5):184-187. doi:10.1016/j.suponc.2011.04.001
  33. 33. Behl D, Jatoi A. What Do Oncologists Say about Chemotherapy at the Very End of Life? Results from a Semiqualitative Survey. Journal of Palliative Medicine. 2010 Jul;13(7):831-835. doi:10.1089/jpm.2009.0414
  34. 34. Stout J, Kumbamu A, Tilburt J, Fernandez C, Geller G, Koenig B, et al. Conversations on Cancer Chemotherapy Cessation in Patients With Advanced Cancer: Qualitative Findings From a Multi-Institutional Study. American Journal of Hospice and Palliative Medicine®. 2021 Feb;38(2):175-179. doi:10.1177/1049909120930710
  35. 35. Buiting HM, Rurup ML, Wijsbek H, van Zuylen L, den Hartogh G. Understanding provision of chemotherapy to patients with end stage cancer: qualitative interview study: Table 1. BMJ Supportive & Palliative Care. 2011 Jun;1(1):33-41. doi:10.1136/bmj.d1933
  36. 36. Mack JW, Cronin A, Keating NL, Taback N, Huskamp HA, Malin JL, et al. Associations Between End-of-Life Discussion Characteristics and Care Received Near Death: A Prospective Cohort Study. Journal of Clinical Oncology. 2012 Dec 10;30(35):4387-4395. doi:10.1200/JCO.2012.43.6055
  37. 37. Thorne SE, Bultz BD, Baile WF. Is there a cost to poor communication in cancer care?: a critical review of the literature. Psycho-Oncology. 2005 Oct;14(10):875-884. doi:10.1002/pon.947
  38. 38. Sinclair C, Gates K, Evans S, Auret KA. Factors Influencing Australian General Practitioners' Clinical Decisions Regarding Advance Care Planning: A Factorial Survey. Journal of Pain and Symptom Management. 2016 Apr;51(4):718-727.e2. doi:10.1016/j.jpainsymman.2015.11.014
  39. 39. Ford J, Hepburn A, Parry R. What do displays of empathy do in palliative care consultations?. Discourse Stud. 2019;21(1):22–37.
  40. 40. Henselmans I, Van Laarhoven HWM, Van der Vloodt J, De Haes HCJM, Smets EMA. Shared decision making about palliative chemotherapy: A qualitative observation of talk about patients’ preferences. Palliative Medicine. 2017 Jul;31(7):625-633. doi:10.1177/0269216316676010
  41. 41. Scherr KA, Fagerlin A, Hofer T, Scherer LD, Holmes-Rovner M, Williamson LD, et al. Physician Recommendations Trump Patient Preferences in Prostate Cancer Treatment Decisions. Medical Decision Making. 2017 Jan;37(1):56-69. doi:10.1177/0272989X16662841
  42. 42. Frosch DL, May SG, Rendle KAS, Tietbohl C, Elwyn G. Authoritarian Physicians And Patients’ Fear Of Being Labeled ‘Difficult’ Among Key Obstacles To Shared Decision Making. Health Affairs. 2012 May;31(5):1030-1038. doi:10.1377/hlthaff.2011.0576
  43. 43. Auspurg K, Hinz T. Factorial survey experiments. Sage Publications; 2014. Available from: https://books.google.com/books?hl=en&lr=&id=1jieBQAAQBAJ&oi=fnd&pg=PP1&dq=info:cjMPya1FESwJ:scholar.google.com&ots=XBqi4IEyR3&sig=WkcqNgQ3QfKcE_bYXj4vbOJ-dKw
  44. 44. Wallander L. 25 years of factorial surveys in sociology: A review. Social Science Research. 2009 Sep;38(3):505-520. doi:10.1016/j.ssresearch.2009.03.004
  45. 45. Jasso G. Factorial Survey Methods for Studying Beliefs and Judgments. Sociological Methods & Research. 2006 Feb;34(3):334-423. doi:10.1177/0049124105283121
  46. 46. van Vliet LM, van der Wall E, Albada A, Spreeuwenberg PMM, Verheul W, Bensing JM. The Validity of Using Analogue Patients in Practitioner–Patient Communication Research: Systematic Review and Meta-Analysis. Journal of General Internal Medicine. 2012 Nov;27(11):1528-1543. doi:10.1007/s11606-012-2111-8
  47. 47. Blanch-Hartigan D, Hall JA, Krupat E, Irish JT. Can Naive Viewers Put Themselves in the Patients’ Shoes?. Medical Care. 2013 Mar;51(3):e16-e21. doi:10.1097/MLR.0b013e31822945cc
  48. 48. Hall JA, Roter DL, Blanch-Hartigan D, Mast MS, Pitegoff CA. How Patient-Centered Do Female Physicians Need to Be? Analogue Patients’ Satisfaction With Male and Female Physicians’ Identical Behaviors. Health Communication. 2015 Sep 2;30(9):894-900. doi:10.1080/10410236.2014.900892
  49. 49. Pieterse AH, Brandes K, de Graaf J, de Boer JE, Labrie NHM, Knops A, et al. Fostering Patient Choice Awareness and Presenting Treatment Options Neutrally: A Randomized Trial to Assess the Effect on Perceived Room for Involvement in Decision Making. Medical Decision Making. 2022 Apr;42(3):375-386. doi:10.1177/0272989X211056334
  50. 50. Degner LF, Sloan JA, Venkatesh P. The Control Preferences Scale. Can J Nurs Res Rev Can Rech En Sci Infirm. 1997;29(3):21–43.
  51. 51. Staeck R, Sauer C, Asch SM, Zambrano SC. Comforting styles of serious illness conversations: a Swiss wide factorial survey study. BMC Medicine. 2025 Apr 14;23(1):218. doi:10.1186/s12916-025-04046-6
  52. 52. Morita T, Akechi T, Ikenaga M, Kizawa Y, Kohara H, Mukaiyama T, et al. Late Referrals to Specialized Palliative Care Service in Japan. Journal of Clinical Oncology. 2005 Apr 20;23(12):2637-2644. doi:10.1200/JCO.2005.12.107
  53. 53. DuMontier C, Loh KP, Bain PA, Silliman RA, Hshieh T, Abel GA. Defining undertreatment and overtreatment in older adults with cancer: a scoping literature review. J Clin Oncol. 2020;38(22):2558–69.
  54. 54. Lorenz KA, Lynn J, Dy SM, Shugarman LR, Wilkinson A, Mularski RA, et al. Evidence for Improving Palliative Care at the End of Life: A Systematic Review. Annals of Internal Medicine. 2008 Jan 15;148(2):147-159. doi:10.7326/0003-4819-148-2-200801150-00010
  55. 55. Ford J, Hepburn A, Parry R. What do displays of empathy do in palliative care consultations?. Discourse Studies. 2019 Feb;21(1):22-37. doi:10.1177/1461445618814030
  56. 56. Henselmans I, Van Laarhoven HWM, Van der Vloodt J, De Haes HCJM, Smets EMA. Shared decision making about palliative chemotherapy: A qualitative observation of talk about patients’ preferences. Palliative Medicine. 2017 Jul;31(7):625-633. doi:10.1177/0269216316676010
  57. 57. Pollak KI, Arnold RM, Jeffreys AS, Alexander SC, Olsen MK, Abernethy AP, et al. Oncologist Communication About Emotion During Visits With Patients With Advanced Cancer. Journal of Clinical Oncology. 2007 Dec 20;25(36):5748-5752. doi:10.1200/JCO.2007.12.4180
  58. 58. Engel M, Kars MC, Teunissen SCCM, van der Heide A. Effective communication in palliative care from the perspectives of patients and relatives: A systematic review. Palliative and Supportive Care. 2023 Oct;21(5):890-913. doi:10.1017/S1478951523001165
  59. 59. Kim H, Flieger SP. Barriers to Effective Communication about Advance Care Planning and Palliative Care: A Qualitative Study. The Korean Journal of Hospice and Palliative Care. 2023 Jun 1;26(2):42-50. doi:10.14475/jhpc.2023.26.2.42
  60. 60. Baxter R, Pusa S, Andersson S, Fromme EK, Paladino J, Sandgren A. Core elements of serious illness conversations: an integrative systematic review. BMJ Supportive & Palliative Care. 2024 Dec;14(e3):e2268-e2279. doi:10.1136/spcare-2023-004163
  61. 61. Ahluwalia SC, Fried TR. Physician factors associated with outpatient palliative care referral. Palliative Medicine. 2009 Oct;23(7):608-615. doi:10.1177/0269216309106315
  62. 62. Dhakal P, Wichman CS, Pozehl BJ, Elnair R, Yellala A, Mahato K. Age and Sex-Based Differences in Therapy Preferences Among Patients with Cancer: Evidence from a Novel Therapy Preference Scale. Res Sq. 2025;3.
  63. 63. Kuhfeld WF, Tobias RD, Garratt M. Efficient Experimental Design with Marketing Research Applications. 2010.
  64. 64. Dülmer H. Experimental Plans in Factorial Surveys. Sociological Methods & Research. 2007 Feb;35(3):382-409. doi:10.1177/0049124106292367
  65. 65. Shamon H, Dülmer H, Giza A. The Factorial Survey: The Impact of the Presentation Format of Vignettes on Answer Behavior and Processing Time. Sociological Methods & Research. 2022 Feb;51(1):396-438. doi:10.1177/0049124119852382
  66. 66. Drewniak D, Brandi G, Buehler PK, Steiger P, Hagenbuch N, Stamm-Balderjahn S, et al. Key Factors in Decision Making for ECLS: A Binational Factorial Survey. Medical Decision Making. 2022 Apr;42(3):313-325. doi:10.1177/0272989X211040815
  67. 67. Button KS, Ioannidis JPA, Mokrysz C, Nosek BA, Flint J, Robinson ESJ, et al. Power failure: why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience. 2013 May;14(5):365-376. doi:10.1038/nrn3475
  68. 68. Madjarova SJ, Pareek A, Eckhardt CM, Khorana A, Kunze KN, Ollivier M, et al. Fragility Part I: a guide to understanding statistical power. Knee Surgery, Sports Traumatology, Arthroscopy. 2022 Dec;30(12):3924-3928. doi:10.1007/s00167-022-07188-9
  69. 69. Serdar CC, Cihan M, Yücel D, Serdar MA. Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies. Biochemia medica. 2021 Feb 15;31(1):27-53. doi:10.11613/BM.2021.010502
  70. 70. Bähler C, Näpflin M, Scherer M, Blozik E. Continuity of care and treatment intensity at the end of life in Swiss cancer patients. European Journal of Public Health. 2023 Jun 1;33(3):396-402. doi:10.1093/eurpub/ckad047
  71. 71. Chen AY, Chen B, Kuo C. Better continuity of care improves the quality of end-of-life care among elderly patients with end-stage renal disease. Scientific Reports. 2020 Nov 12;10(1):19716. doi:10.1038/s41598-020-76707-w
  72. 72. Kao AC, Green DC, Davis NA, Koplan JP, Cleary PD. Patients’ trust in their physicians. Journal of General Internal Medicine. 1998 Oct;13(10):681-686. doi:10.1046/j.1525-1497.1998.00204.x
  73. 73. Lerch SP, Hänggi R, Bussmann Y, Lörwald A. A model of contributors to a trusting patient-physician relationship: a critical review using a systematic search strategy. BMC Primary Care. 2024 Jun 1;25(1):194. doi:10.1186/s12875-024-02435-z
  74. 74. Thom DH, Ribisl KM, Stewart AL, Luke DA. Further Validation and Reliability Testing of the Trust in Physician Scale. Med Care. 1999 May;37(5):510.
  75. 75. Lelorain S, Gehenne L, Christophe V, Duprez C. The association of physician empathy with cancer patient outcomes: A meta‐analysis. Psycho-Oncology. 2023 Apr;32(4):506-515. doi:10.1002/pon.6108
  76. 76. Zink K, Perry M, London K, Floto O, Bassin B, Burkhardt J, et al. “Let Me Tell You About My...” Provider Self-Disclosure in the Emergency Department Builds Patient Rapport. Western Journal of Emergency Medicine. 2017 Jan 19;18(1):43-49. doi:10.5811/westjem.2016.10.31014
  77. 77. Rousseau PC. Physician Self-Disclosure at the End of Life: Is it Beneficial?. Journal of Palliative Medicine. 2009 Nov;12(11):993-994. doi:10.1089/jpm.2009.9942
  78. 78. McDaniel SH, Morse DS, Edwardsen EA, Taupin A, Gurnsey MG, Griggs JJ, et al. Empathy and boundary turbulence in cancer communication. Patient Education and Counseling. 2021 Dec;104(12):2944-2951. doi:10.1016/j.pec.2021.04.002
  79. 79. Gabbard GO. Professional Boundaries in the Physician-Patient Relationship. JAMA: The Journal of the American Medical Association. 1995 May 10;273(18):1445. doi:10.1001/jama.1995.03520420061039
  80. 80. Janssens KME, Sweerts C, Vingerhoets AJJM. The Physician’s Tears: Experiences and Attitudes of Crying Among Physicians and Medical Interns. Journal of Clinical Psychology in Medical Settings. 2019 Dec;26(4):411-420. doi:10.1007/s10880-019-09611-9
  81. 81. Frongillo M, Feibelmann S, Belkora J, Lee C, Sepucha K. Is there shared decision making when the provider makes a recommendation?. Patient Education and Counseling. 2013 Jan;90(1):69-73. doi:10.1016/j.pec.2012.08.016
  82. 82. Puts MTE, Sattar S, McWatters K, Lee K, Kulik M, MacDonald M, et al. Chemotherapy treatment decision-making experiences of older adults with cancer, their family members, oncologists and family physicians: a mixed methods study. Supportive Care in Cancer. 2017 Mar;25(3):879-886. doi:10.1007/s00520-016-3476-8
  83. 83. Kneuertz PJ, Chang GJ, Hu C, Rodriguez-Bigas MA, Eng C, Vilar E, et al. Overtreatment of Young Adults With Colon Cancer. JAMA Surgery. 2015 May 1;150(5):402. doi:10.1001/jamasurg.2014.3572
  84. 84. Chen RC, Falchook AD, Tian F, Basak R, Hanson L, Selvam N, et al. Aggressive care at the end-of-life for younger patients with cancer: Impact of ASCO's Choosing Wisely campaign.. Journal of Clinical Oncology. 2016 Jun 20;34(18_suppl):LBA10033-LBA10033. doi:10.1200/JCO.2016.34.18_suppl.LBA10033
  85. 85. Bähler C, Signorell A, Blozik E, Reich O. Intensity of treatment in Swiss cancer patients at the end-of-life. Cancer Management and Research. 2018 Mar;Volume 10:481-491. doi:10.2147/CMAR.S156566
  86. 86. Craigs CL, Bennett MI, Hurlow A, West RM, Ziegler LE. Older age is associated with less cancer treatment: a longitudinal study of English cancer patients. Age and Ageing. 2018 Nov 1;47(6):833-840. doi:10.1093/ageing/afy094
  87. 87. Niederhauser A, Egloff M, Eychmueller S, Zambrano SC. Adapting to the emotional complexity of palliative care communication: Palliative care clinicians’ experiences. Palliative and Supportive Care. 2025;23:e43. doi:10.1017/S1478951524001883
  88. 88. Cohen J. A power primer.. Psychological Bulletin. 1992;112(1):155-159. doi:10.1037/0033-2909.112.1.155