Original article
Vol. 151 No. 4142 (2021)
Open aneurysm repair in patients with concomitant abdominal aortic aneurysm and aorto-iliac occlusive disease is associated with a high mortality and surgical complication rate
- Sabine Richarz
- Soheila Aghlmandi
- Andrei Zdoroveac
- Alexandra Müller
- Andrej Isaak
- Lorenz Gürke
- Thomas Wolff
Summary
AIM OF THE STUDY: To evaluate whether the outcome after open aneurysm repair combined with aorto-femoral bypass in patients with concomitant abdominal aortic aneurysm (AAA) and aorto-iliac occlusive disease (AIOD) is inferior to open aneurysm repair for isolated AAA or aorto-femoral bypass for isolated AIOD.
METHODS: We performed a retrospective analysis of 30-day mortality, 1-year mortality and surgical complications of consecutive patients undergoing elective aneurysm repair, aorto-femoral bypass or a combination of these at two vascular surgery departments from 2003 to 2013. Potential risk factors were investigated by multivariable analysis.
RESULTS: Overall, 511 patients underwent open repair for isolated AAA, 104 aorto-femoral bypass for isolated AIOD and 46 open AAA repair combined with aorto-femoral bypass for concomitant AAA and AIOD. Surgical complications occurred in 17% of AAA, 23% of AIOD and 37% of combined patients (odds ratio [OR] combined vs AAA 2.76, 95% confidence interval [CI] 1.43–5.34; p = 0.003). Colon ischaemia occurred in 3.7% of AAA, 2.9% of AIOD and 13% of combined patients (incicidence rate ratio [IRR] combined vs AAA 3.27, 95% CI 1.37–7.81; p = 0.01). The 30-day mortality was 3.1% in AAA, 4.8% in AIOD, and 11% in combined patients (IRR combined vs AAA 3.17, 95% CI 1.26–7.96; p = 0.01). One-year mortality was 5.7% in AAA, 5.8% in AIOD and 15% in combined patients (IRR combined vs AAA 2.50, 95% CI 1.17–5.35; p = 0.02).
CONCLUSIONS: Combined AAA repair and aorto-femoral bypass has a significantly higher 30-day mortality and postoperative complication rate than isolated AAA repair. Patients with concomitant AAA and AIOD thus represent a high-risk population, which should be considered when deciding on the indication for AAA treatment.
References
- Biancari F, Leo E, Ylönen K, Vaarala MH, Rainio P, Juvonen T. Value of the Glasgow Aneurysm Score in predicting the immediate and long-term outcome after elective open repair of infrarenal abdominal aortic aneurysm. Br J Surg. 2003 Jul;90(7):838–44. https://doi.org/10.1002/bjs.4130
- McPhee JT, Hill JS, Eslami MH. The impact of gender on presentation, therapy, and mortality of abdominal aortic aneurysm in the United States, 2001-2004. J Vasc Surg. 2007 May;45(5):891–9. https://doi.org/10.1016/j.jvs.2007.01.043
- Brady AR, Fowkes FG, Greenhalgh RM, Powell JT, Ruckley CV, Thompson SG. Risk factors for postoperative death following elective surgical repair of abdominal aortic aneurysm: results from the UK Small Aneurysm Trial. On behalf of the UK Small Aneurysm Trial participants. Br J Surg. 2000 Jun;87(6):742–9. https://doi.org/10.1046/j.1365-2168.2000.01410.x
- Bayly PJ, Matthews JN, Dobson PM, Price ML, Thomas DG. In-hospital mortality from abdominal aortic surgery in Great Britain and Ireland: Vascular Anaesthesia Society audit. Br J Surg. 2001 May;88(5):687–92. https://doi.org/10.1046/j.0007-1323.2001.01778.x
- Bredahl K, Jensen LP, Schroeder TV, Sillesen H, Nielsen H, Eiberg JP. Mortality and complications after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease. J Vasc Surg. 2015 Jul;62(1):75–82. https://doi.org/10.1016/j.jvs.2015.02.025
- Daniel VT, Gupta N, Raffetto JD, McPhee JT. Impact of coexisting aneurysms on open revascularization for aortoiliac occlusive disease. J Vasc Surg. 2016 Apr;63(4):944–8. https://doi.org/10.1016/j.jvs.2015.10.062
- Bisgaard J, Gilsaa T, Rønholm E, Toft P. Aortic aneurysm disease vs. aortic occlusive disease: differences in outcome and intensive care resource utilisation after elective surgery: an observational study. Eur J Anaesthesiol. 2013 Feb;30(2):65–72. https://doi.org/10.1097/EJA.0b013e32835b9d7b
- Costin JA, Watson DR, Duff SB, Edmonson-Holt A, Shaffer L, Blossom GB. Evaluation of the complexity of open abdominal aneurysm repair in the era of endovascular stent grafting. J Vasc Surg. 2006 May;43(5):915–20. https://doi.org/10.1016/j.jvs.2006.01.017
- Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004 Aug;240(2):205–13. https://doi.org/10.1097/01.sla.0000133083.54934.ae
- Dovzhanskiy DI, Bischoff MS, Wilichowski CD, Rengier F, Klempka A, Böckler D. Outcome analysis and risk factors for postoperative colonic ischaemia after aortic surgery. Langenbecks Arch Surg. 2020 Nov;405(7):1031–8. https://doi.org/10.1007/s00423-020-01964-2
- Williamson JS, Ambler GK, Twine CP, Williams IM, Williams GL. Elective Repair of Abdominal Aortic Aneurysm and the Risk of Colonic Ischaemia: Systematic Review and Meta-Analysis. Eur J Vasc Endovasc Surg. 2018 Jul;56(1):31–9. https://doi.org/10.1016/j.ejvs.2018.03.005
- Landry GJ, Liem TK, Abraham CZ, Jung E, Moneta GL. Predictors of perioperative morbidity and mortality in open abdominal aortic aneurysm repair. Am J Surg. 2019 May;217(5):943–7. https://doi.org/10.1016/j.amjsurg.2018.12.054
- Dillavou ED, Muluk SC, Makaroun MS. A decade of change in abdominal aortic aneurysm repair in the United States: have we improved outcomes equally between men and women? J Vasc Surg. 2006 Feb;43(2):230–8. https://doi.org/10.1016/j.jvs.2005.09.043
- Beck AW, Goodney PP, Nolan BW, Likosky DS, Eldrup-Jorgensen J, Cronenwett JL ; Vascular Study Group of Northern New England. Predicting 1-year mortality after elective abdominal aortic aneurysm repair. J Vasc Surg. 2009 Apr;49(4):838–43. https://doi.org/10.1016/j.jvs.2008.10.067
- Deery SE, Lancaster RT, Baril DT, Indes JE, Bertges DJ, Conrad MF, et al. Contemporary outcomes of open complex abdominal aortic aneurysm repair. J Vasc Surg. 2016 May;63(5):1195–200. https://doi.org/10.1016/j.jvs.2015.12.038
- Dubois L, Durant C, Harrington DM, Forbes TL, Derose G, Harris JR. Technical factors are strongest predictors of postoperative renal dysfunction after open transperitoneal juxtarenal abdominal aortic aneurysm repair. J Vasc Surg. 2013 Mar;57(3):648–54. https://doi.org/10.1016/j.jvs.2012.09.043
- Chong T, Nguyen L, Owens CD, Conte MS, Belkin M. Suprarenal aortic cross-clamp position: a reappraisal of its effects on outcomes for open abdominal aortic aneurysm repair. J Vasc Surg. 2009 Apr;49(4):873–80. https://doi.org/10.1016/j.jvs.2008.10.057
- Senekowitsch C, Assadian A, Assadian O, Hartleb H, Ptakovsky H, Hagmüller GW. Replanting the inferior mesentery artery during infrarenal aortic aneurysm repair: influence on postoperative colon ischemia. J Vasc Surg. 2006 Apr;43(4):689–94. https://doi.org/10.1016/j.jvs.2005.12.016