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Original article

Vol. 151 No. 3536 (2021)

Bilateral proximal hamstring muscle avulsion after treatment with immune checkpoint inhibitors and corticosteroids

  • Nicolas Frei
  • Federico Caobelli
  • Diego Kyburz
Cite this as:
Swiss Med Wkly. 2021;151:w30011


A 66-year-old man presented with 4 weeks of bilateral buttock pain without previous trauma or intense exercise. He had been treated with immune checkpoint inhibitors because of metastasising melanoma and experienced immune-related adverse events requiring treatment with corticosteroids. Magnetic resonance imaging of the pelvis revealed bilateral avulsion of the proximal hamstring muscles. Treatment with physical therapy and nonsteroidal anti-inflammatory drugs led to a slow but lasting relief. This is, to our knowledge, the first report of symptomatic non-traumatic bilateral hamstring muscle avulsion following treatment with immune checkpoint inhibitors and corticosteroids.


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