Original article
Vol. 151 No. 0708 (2021)
Iatrogenic events contributing to paediatric intensive care unit admission
- Romana Salvini
- Bernhard Frey
Summary
AIMS
To identify the incidence of iatrogenic events leading to paediatric intensive care unit (PICU) admission and to analyse these patients regarding demographic, illness severity and outcome parameters.
MATERIAL AND METHODS
This was a retrospective case series. The computerised charts of all patients admitted to the multidisciplinary, tertiary, 18-bed PICU in 2014 were analysed. Iatrogenic events leading to PICU admission were identified and their preventability assessed. Underlying diseases, causes of iatrogenic events, illness severity at PICU admission, presence of complex chronic conditions, patient origin, length of stay on the PICU and outcome were analysed.
RESULTS
There were 138 admissions associated with iatrogenic events out of 1102 admissions (12.5%). Ninety iatrogenic events led to unplanned admissions and 48 cases concerned scheduled admissions, where the iatrogenic event would have led to PICU admission by itself or caused a second, planned PICU admission for re-operation. Iatrogenic complications during surgery (31% of all iatrogenic events), wrong management decisions / delayed diagnoses (20%) and nosocomial infections (14%) were the categories most often involved. Regarding origin of the patients, the greatest difference between iatrogenic event admissions and non-iatrogenic event admissions was found for the ward (21% vs 11%). The patients admitted for iatrogenic events had a higher mean expected mortality (8.4 vs 4.7%, p = 0.02) and a higher observed PICU mortality (5.8 vs 3.3%, p = 0.15). Of all iatrogenic events, 60.1% were judged to be preventable. The highest preventability rate was found in the categories “nosocomial infections” (100%) and “management decisions / delayed diagnoses” (92.9%).
CONCLUSION
In our setting, the number of PICU admissions associated with iatrogenic events is significant and comparable to adult data on admission to ICU caused by iatrogenic events. The categories with most potential for improvement are nosocomial infections and the wrong management decisions / delayed diagnoses. Focused measures on these iatrogenic events may have a major impact on patient outcome, availability of PICU resources and healthcare costs.
References
- Kohn LT, Corrigan JM, Donaldson MS, eds. To err is human: Building a Safer Health System. Washington: The National Academies Press; 2018.
- Rothschild JM, Landrigan CP, Cronin JW, Kaushal R, Lockley SW, Burdick E, et al. The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care. Crit Care Med. 2005;33(8):1694–700. doi:.https://doi.org/10.1097/01.CCM.0000171609.91035.BD
- Firth-Cozens J. Barriers to incident reporting. Qual Saf Health Care. 2002;11(1):7. doi:.https://doi.org/10.1136/qhc.11.1.7
- Walsh KE, Harik P, Mazor KM, Perfetto D, Anatchkova M, Biggins C, et al. Measuring Harm in Health Care: Optimizing Adverse Event Review. Med Care. 2017;55(4):436–41. doi:.https://doi.org/10.1097/MLR.0000000000000679
- Trunet P, Le Gall JR, Lhoste F, Regnier B, Saillard Y, Carlet J, et al. The role of iatrogenic disease in admissions to intensive care. JAMA. 1980;244(23):2617–20. doi:.https://doi.org/10.1001/jama.1980.03310230019015
- Lehmann LS, Puopolo AL, Shaykevich S, Brennan TA. Iatrogenic events resulting in intensive care admission: frequency, cause, and disclosure to patients and institutions. Am J Med. 2005;118(4):409–13. doi:.https://doi.org/10.1016/j.amjmed.2005.01.012
- Darchy B, Le Mière E, Figuérédo B, Bavoux E, Domart Y. Iatrogenic diseases as a reason for admission to the intensive care unit: incidence, causes, and consequences. Arch Intern Med. 1999;159(1):71–8. doi:.https://doi.org/10.1001/archinte.159.1.71
- Mercier E, Giraudeau B, Giniès G, Perrotin D, Dequin PF. Iatrogenic events contributing to ICU admission: a prospective study. Intensive Care Med. 2010;36(6):1033–7. doi:.https://doi.org/10.1007/s00134-010-1793-9
- O’Brien S, Nadel S, Almossawi O, Inwald DP. The Impact of Chronic Health Conditions on Length of Stay and Mortality in a General PICU. Pediatr Crit Care Med. 2017;18(1):1–7. doi:.https://doi.org/10.1097/PCC.0000000000000976
- Edwards JD, Houtrow AJ, Vasilevskis EE, Rehm RS, Markovitz BP, Graham RJ. Chronic conditions among children admitted to U.S. pediatric intensive care units: their prevalence and impact on risk for mortality and prolonged length of stay. Crit Care Med. 2012;40(7):2196–203. doi:.https://doi.org/10.1097/CCM.0b013e31824e68cf
- Schweizerische Gesellschaft für Intensivmedizin. [Internet]. Available from: https://www.sgi-ssmi.ch/de/datensatz.html
- Reis Miranda D, Moreno R, Iapichino G. Nine equivalents of nursing manpower use score (NEMS). Intensive Care Med. 1997;23(7):760–5. doi:.https://doi.org/10.1007/s001340050406
- Slater A, Shann F, Pearson G ; Paediatric Index of Mortality (PIM) Study Group. PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med. 2003;29(2):278–85. doi:.https://doi.org/10.1007/s00134-002-1601-2
- Slater A, Shann F, McEniery J ; ANICS Study Group. The ANZPIC registry diagnostic codes: a system for coding reasons for admitting children to intensive care. Intensive Care Med. 2003;29(2):271–7. doi:.https://doi.org/10.1007/s00134-002-1600-3
- Feudtner C, Christakis DA, Connell FA. Pediatric deaths attributable to complex chronic conditions: a population-based study of Washington State, 1980-1997. Pediatrics. 2000;106(1 Pt 2):205–9.
- Poidevin A, Egard M, Guiot P, Kuteifan K. L’événement indésirable grave: un motif d’admission fréquent en réanimation [Iatrogenic events: a significant cause of admission in intensive care units]. Ann Fr Anesth Reanim. 2014;33(9-10):503–7. Article in French. doi:.https://doi.org/10.1016/j.annfar.2014.06.005
- Sefton G, McGrath C, Tume L, Lane S, Lisboa PJG, Carrol ED. What impact did a Paediatric Early Warning system have on emergency admissions to the paediatric intensive care unit? An observational cohort study. Intensive Crit Care Nurs. 2015;31(2):91–9. doi:.https://doi.org/10.1016/j.iccn.2014.01.001
- Ricci M, Goldman AP, de Leval MR, Cohen GA, Devaney F, Carthey J. Pitfalls of adverse event reporting in paediatric cardiac intensive care. Arch Dis Child. 2004;89(9):856–9. doi:.https://doi.org/10.1136/adc.2003.040154
- Sharek PJ, Horbar JD, Mason W, Bisarya H, Thurm CW, Suresh G, et al. Adverse events in the neonatal intensive care unit: development, testing, and findings of an NICU-focused trigger tool to identify harm in North American NICUs. Pediatrics. 2006;118(4):1332–40. doi:.https://doi.org/10.1542/peds.2006-0565
- Frey B, Buettiker V, Hug MI, Waldvogel K, Gessler P, Ghelfi D, et al. Does critical incident reporting contribute to medication error prevention? Eur J Pediatr. 2002;161(11):594–9. doi:.https://doi.org/10.1007/s00431-002-1055-0