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Original article

Vol. 147 No. 2930 (2017)

A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users

DOI
https://doi.org/10.4414/smw.2017.14469
Cite this as:
Swiss Med Wkly. 2017;147:w14469
Published
24.07.2017

Summary

Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (43%) and emm types stG62647.0 (26%) were the most frequent clinical manifestation and emm type, respectively. Nineteen (28%) episodes occurred in intravenous drug users (75% women). Our observational study shows similarities to but also differences from other reports. The former include the most frequent clinical presentations, and the most frequently found emm types. This report highlights a relatively high proportion of female intravenous drug users among S. dysgalactiae bacteraemia episodes.

References

  1. Takahashi T, Ubukata K, Watanabe H. Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features. J Infect Chemother. 2011;17(1):1–10. doi:.https://doi.org/10.1007/s10156-010-0084-2
  2. Brandt CM, Spellerberg B. Human infections due to Streptococcus dysgalactiae subspecies equisimilis. Clin Infect Dis. 2009;49(5):766–72. doi:.https://doi.org/10.1086/605085
  3. Rantala S. Streptococcus dysgalactiae subsp. equisimilis bacteremia: an emerging infection. Eur J Clin Microbiol Infect Dis. 2014;33(8):1303–10. doi:.https://doi.org/10.1007/s10096-014-2092-0
  4. Broyles LN, Van Beneden C, Beall B, Facklam R, Shewmaker PL, Malpiedi P, et al. Population-based study of invasive disease due to beta-hemolytic streptococci of groups other than A and B. Clin Infect Dis. 2009;48(6):706–12. doi:.https://doi.org/10.1086/597035
  5. Loubinoux J, Plainvert C, Collobert G, Touak G, Bouvet A, Poyart C ; CNR-Strep Network. Adult invasive and noninvasive infections due to Streptococcus dysgalactiae subsp. equisimilis in France from 2006 to 2010. J Clin Microbiol. 2013;51(8):2724–7. doi:.https://doi.org/10.1128/JCM.01262-13
  6. Oppegaard O, Mylvaganam H, Kittang BR. Beta-haemolytic group A, C and G streptococcal infections in Western Norway: a 15-year retrospective survey. Clin Microbiol Infect. 2015;21(2):171–8. doi:.https://doi.org/10.1016/j.cmi.2014.08.019
  7. Trell K, Nilson B, Rasmussen M. Species and emm-type distribution of group C and G streptococci from different sites of isolation. Diagn Microbiol Infect Dis. 2016;86(4):467–9. doi:.https://doi.org/10.1016/j.diagmicrobio.2016.09.008
  8. Liao CH, Liu LC, Huang YT, Teng LJ, Hsueh PR. Bacteremia caused by group G Streptococci, taiwan. Emerg Infect Dis. 2008;14(5):837–40. doi:.https://doi.org/10.3201/eid1405.070130
  9. Rantala S, Vahakuopus S, Vuopio-Varkila J, Vuento R, Syrjanen J. Streptococcus dysgalactiae subsp. equisimilis Bacteremia, Finland, 1995-2004. Emerg Infect Dis. 2010;16(5):843–6. doi:.https://doi.org/10.3201/eid1605.080803
  10. Trell K, Sendi P, Rasmussen M. Recurrent bacteremia with Streptococcus dysgalactiae: a case-control study. Diagn Microbiol Infect Dis. 2016;85(1):121–4. doi:.https://doi.org/10.1016/j.diagmicrobio.2016.01.011
  11. Takahashi T, Asami R, Tanabe K, Hirono Y, Nozawa Y, Chiba N, et al. Clinical aspects of invasive infection with Streptococcus dysgalactiae subsp. equisimilis in elderly patients. J Infect Chemother. 2010;16(1):68–71. doi:.https://doi.org/10.1007/s10156-009-0016-1
  12. Navarro VJ, Axelrod PI, Pinover W, Hockfield HS, Kostman JR. A comparison of Streptococcus pyogenes (group A streptococcal) bacteremia at an urban and a suburban hospital. The importance of intravenous drug use. Arch Intern Med. 1993;153(23):2679–84. doi:.https://doi.org/10.1001/archinte.1993.00410230097011
  13. Bernaldo de Quirós JC, Moreno S, Cercenado E, Diaz D, Berenguer J, Miralles P, et al. Group A streptococcal bacteremia. A 10-year prospective study. Medicine (Baltimore). 1997;76(4):238–48. doi:.https://doi.org/10.1097/00005792-199707000-00002
  14. Léchot P, Schaad HJ, Graf S, Täuber M, Mühlemann K ; Patricia Léchot, Heinz J. Schaad, S. Group A streptococcus clones causing repeated epidemics and endemic disease in intravenous drug users. Scand J Infect Dis. 2001;33(1):41–6. doi:.https://doi.org/10.1080/003655401750064059
  15. Lambertsen LM, Ingels H, Schønheyder HC, Hoffmann S ; Danish Streptococcal Surveillance Collaboration Group 2011. Nationwide laboratory-based surveillance of invasive beta-haemolytic streptococci in Denmark from 2005 to 2011. Clin Microbiol Infect. 2014;20(4):O216–23. doi:.https://doi.org/10.1111/1469-0691.12378
  16. Schwartz IS, Keynan Y, Gilmour MW, Dufault B, Lagacé-Wiens P. Changing trends in β-hemolytic streptococcal bacteremia in Manitoba, Canada: 2007-2012. Int J Infect Dis. 2014;28:211–3. doi:.https://doi.org/10.1016/j.ijid.2014.03.1376
  17. Harris P, Siew DA, Proud M, Buettner P, Norton R. Bacteraemia caused by beta-haemolytic streptococci in North Queensland: changing trends over a 14-year period. Clin Microbiol Infect. 2011;17(8):1216–22. doi:.https://doi.org/10.1111/j.1469-0691.2010.03427.x
  18. Pinho MD, Melo-Cristino J, Ramirez M. Clonal relationships between invasive and noninvasive Lancefield group C and G streptococci and emm-specific differences in invasiveness. J Clin Microbiol. 2006;44(3):841–6. doi:.https://doi.org/10.1128/JCM.44.3.841-846.2006

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