Skip to main navigation menu Skip to main content Skip to site footer

Review article: Biomedical intelligence

Vol. 146 No. 4546 (2016)

Choosing wisely at the end of life: the crucial role of medical indication

  • Gian Domenico Borasio
  • Ralf J. Jox
DOI
https://doi.org/10.4414/smw.2016.14369
Cite this as:
Swiss Med Wkly. 2016;146:w14369
Published
06.11.2016

Summary

At the end of life, several treatments are administered routinely that lack medical indication and may cause significant harm to patients. Examples include artificial hydration and oxygen therapy in the dying phase, as well as enteral nutrition in advanced dementia.

Medical indication is defined as the appropriateness of a therapeutic or diagnostic measure in the patient’s concrete clinical situation, in light of the best available evidence. The decision about the absence or presence of a medical indication is a core competence of physicians. They have no obligation to perform or even mention measures that are not indicated. The decision about medical indication is a clinical compound decision, composed of both a factual, evidence-based judgement and a value judgement, which should always be patient-centred.

Acknowledging the crucial role of medical indication in clinical decision making in medicine generally and at the end of life specifically opens up ways of enhancing patient-physician communication by clarifying roles, responsibilities and competencies. This may facilitate preventing overtreatment, improving patient wellbeing, and realising the patients’ goals of care.

References

  1. Morden NE, Colla CH, Sequist TD, Rosenthal MB. Choosing wisely – the politics and economics of labeling low-value services. N Engl J Med. 2014;370(7):589–92. doi:http://dx.doi.org/10.1056/NEJMp1314965.
  2. Wolfson D, Santa J, Slass L. Engaging physicians and consumers in conversations about treatment overuse and waste: a short history of the choosing wisely campaign. Acad Med. 2014;89(7):990–5. doi:http://dx.doi.org/10.1097/ACM.0000000000000270.
  3. Rosenberg A, Agiro A, Gottlieb M, Barron J, Brady P, Liu Y, et al. Early Trends Among Seven Recommendations From the Choosing Wisely Campaign. JAMA Intern Med. 2015;175(12):1913–20. doi:http://dx.doi.org/10.1001/jamainternmed.2015.5441.
  4. Gaspoz JM. Smarter medicine: do physicians need political pressure to eliminate useless interventions? Swiss Med Wkly. 2015;145:w14125.
  5. Swiss Academy of Medical Sciences. Sustainable medicine. Position paper. Basel: SAMW; 2012.
  6. Hasenfuss G, Märker-Herrmann E, Hallek M, Fölsch UR. Initiative «Klug entscheiden». Gegen Unter- und Überversorgung. Dtsch Arztebl. 2016;113:A600. German.
  7. Jox RJ, Schaider A, Marckmann G, Borasio GD. Medical futility at the end of life: the perspectives of intensive care and palliative care clinicians. J Med Ethics. 2012;38(9):540–5. doi:http://dx.doi.org/10.1136/medethics-2011-100479.
  8. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363(8):733–42. doi:http://dx.doi.org/10.1056/NEJMoa1000678.
  9. Dörries A, Lipp V. Medizinische Indikation. Ärztliche, ethische und rechtliche Perspektiven. Grundlagen und Praxis. Stuttgart: Kohlhammer; 2015. German.
  10. Schneiderman LJ. Defining Medical Futility and Improving Medical Care. J Bioeth Inq. 2011;8(2):123–31. doi:http://dx.doi.org/10.1007/s11673-011-9293-3.
  11. Beauchamp TL, Childress JF. Principles of Biomedical Ethics. 7th ed. New York Oxford: Oxford University Press; 2013.
  12. Austin CA, Mohottige D, Sudore RL, Smith AK, Hanson LC. Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review. JAMA Intern Med. 2015;175(7):1213–21. doi:http://dx.doi.org/10.1001/jamainternmed.2015.1679.
  13. Morita T, Hyodo I, Yoshimi T, Ikenaga M, Tamura Y, Yoshizawa A, et al.; Japan Palliative Oncology Study Group. Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies. Ann Oncol. 2005;16(4):640–7. doi:http://dx.doi.org/10.1093/annonc/mdi121.
  14. Hui D, Dev R, Bruera E. The last days of life: symptom burden and impact on nutrition and hydration in cancer patients. Curr Opin Support Palliat Care. 2015;9(4):346–54. doi:http://dx.doi.org/10.1097/SPC.0000000000000171.
  15. Rösler A, Pfeil S, Lessmann H, Höder J, Befahr A, von Renteln-Kruse W. Dysphagia in Dementia: Influence of Dementia Severity and Food Texture on the Prevalence of Aspiration and Latency to Swallow in Hospitalized Geriatric Patients. J Am Med Dir Assoc. 2015;16(8):697–701. doi:http://dx.doi.org/10.1016/j.jamda.2015.03.020.
  16. Volicer L. Dementias. In: Voltz R, Bernat JL, Borasio GD, editors. Palliative Care in Neurology. Oxford: Oxford University Press; 2004.
  17. Mitchell SL, Teno JM, Kiely DK, Shaffer ML, Jones RN, Prigerson HG, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361(16):1529–38. doi:http://dx.doi.org/10.1056/NEJMoa0902234.
  18. Goldberg LS, Altman KW. The role of gastrostomy tube placement in advanced dementia with dysphagia: a critical review. Clin Interv Aging. 2014;9:1733–9. doi:http://dx.doi.org/10.2147/CIA.S53153.
  19. Cervo FA, Bryan L, Farber S. To PEG or not to PEG: a review of evidence for placing feeding tubes in advanced dementia and the decision-making process. Geriatrics. 2006;61(6):30–5.
  20. Sampson EL, Candy B, Jones L. Enteral tube feeding for older people with advanced dementia. Cochrane Database Syst Rev. 2009;(2):CD007209.
  21. Fox KA, Mularski RA, Sarfati MR, Brooks ME, Warneke JA, Hunter GC, et al. Aspiration pneumonia following surgically placed feeding tubes. Am J Surg. 1995;170(6):564–7, discussion 566–7. doi:http://dx.doi.org/10.1016/S0002-9610(99)80016-6.
  22. Bliss DZ, Johnson S, Savik K, Clabots CR, Willard K, Gerding DN. Acquisition of Clostridium difficile and Clostridium difficile-associated diarrhea in hospitalized patients receiving tube feeding. Ann Intern Med. 1998;129(12):1012–9. doi:http://dx.doi.org/10.7326/0003-4819-129-12-199812150-00004.
  23. Moran C, O’Mahony S. When is feeding via a percutaneous endoscopic gastrostomy indicated? Curr Opin Gastroenterol. 2015;31(2):137–42. doi:http://dx.doi.org/10.1097/MOG.0000000000000152.
  24. American Geriatrics Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society feeding tubes in advanced dementia position statement. J Am Geriatr Soc. 2014;62(8):1590–3. doi:http://dx.doi.org/10.1111/jgs.12924.
  25. Fischberg D, Bull J, Casarett D, Hanson LC, Klein SM, Rotella J, et al.; HPM Choosing Wisely Task Force. Five things physicians and patients should question in hospice and palliative medicine. J Pain Symptom Manage. 2013;45(3):595–605. doi:http://dx.doi.org/10.1016/j.jpainsymman.2012.12.002.
  26. Carlsson J, Paul NW, Dann M, Neuzner J, Pfeiffer D. The deactivation of implantable cardioverter-defibrillators: medical, ethical, practical, and legal considerations. Dtsch Arztebl Int. 2012;109(33-34):535–41.
  27. Siqueira D, Abizaid A, Arrais M, Sousa JE. Transcatheter aortic valve replacement in elderly patients. J Geriatr Cardiol. 2012;9(2):78–82. doi:http://dx.doi.org/10.3724/SP.J.1263.2011.12291.
  28. Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA. Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ. 2014;348(feb11 9):g366. doi:http://dx.doi.org/10.1136/bmj.g366.
  29. Hogan DB. Long-term efficacy and toxicity of cholinesterase inhibitors in the treatment of Alzheimer disease. Can J Psychiatry. 2014;59(12):618–23.
  30. Robinson S, Kissane DW, Brooker J, Burney S. A Review of the Construct of Demoralization: History, Definitions, and Future Directions for Palliative Care. Am J Hosp Palliat Care. 2016;33(1):93–101. doi:http://dx.doi.org/10.1177/1049909114553461.
  31. Pistoia F, Sacco S, Sarà M, Carolei A. The perception of pain and its management in disorders of consciousness. Curr Pain Headache Rep. 2013;17(11):374. doi:http://dx.doi.org/10.1007/s11916-013-0374-3.
  32. Jox RJ, Michalowski S, Lorenz J, Schildmann J. Substitute decision making in medicine: comparative analysis of the ethico-legal discourse in England and Germany. Med Health Care Philos. 2008;11(2):153–63. doi:http://dx.doi.org/10.1007/s11019-007-9112-0.
  33. Fagerlin A, Schneider CE. Enough. The failure of the living will. Hastings Cent Rep. 2004;34(2):30–42. doi:http://dx.doi.org/10.2307/3527683.
  34. Jox RJ, In der Schmitten J, Marckmann G. Ethische Grenzen und Defizite der Patientenverfügung. In: Coors M, Jox RJ, In der Schmitten J, editors. Advance Care Planning Von der Patientenverfügung zur gesundheitlichen Vorausplanung. Stuttgart: Kohlhammer; 2015. German.
  35. Hammes BJ, Rooney BL. Death and end-of-life planning in one midwestern community. Arch Intern Med. 1998;158(4):383–90. doi:http://dx.doi.org/10.1001/archinte.158.4.383.
  36. In der Schmitten J, Lex K, Mellert C, Rothärmel S, Wegscheider K, Marckmann G. Implementing an advance care planning program in German nursing homes: results of an inter-regionally controlled intervention trial. Dtsch Arztebl Int. 2014;111(4):50–7.
  37. Houben CH, Spruit MA, Groenen MT, Wouters EF, Janssen DJ. Efficacy of advance care planning: a systematic review and meta-analysis. J Am Med Dir Assoc. 2014;15(7):477–89. doi:http://dx.doi.org/10.1016/j.jamda.2014.01.008.
  38. Brinkman-Stoppelenburg A, Rietjens JA, van der Heide A. The effects of advance care planning on end-of-life care: a systematic review. Palliat Med. 2014;28(8):1000–25. doi:http://dx.doi.org/10.1177/0269216314526272.
  39. Mitchell JD, Borasio GD. Amyotrophic lateral sclerosis. Lancet. 2007;369(9578):2031–41. doi:http://dx.doi.org/10.1016/S0140-6736(07)60944-1.
  40. Bernacki RE, Block SD; American College of Physicians High Value Care Task Force. Communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med. 2014;174(12):1994–2003. doi:http://dx.doi.org/10.1001/jamainternmed.2014.5271.
  41. Wendler D, Rid A. Systematic review: the effect on surrogates of making treatment decisions for others. Ann Intern Med. 2011;154(5):336–46. doi:http://dx.doi.org/10.7326/0003-4819-154-5-201103010-00008.
  42. Kierkegaard S. Synspunkter for min Forfatter Virksomhet (Der Gesichtspunkt für meine Wirksamkeit als Schriftsteller) 1859. In: Kierkegaard S, ed. Die Schriften über sich selbst. Regensburg: Eugen Diederichs Verlag; 1951:38–9. German.
  43. Levinson W, Kallewaard M, Bhatia RS, Wolfson D, Shortt S, Kerr EA; Choosing Wisely International Working Group. "Choosing Wisely": a growing international campaign. BMJ Qual Saf. 2015;24(2):167-74. doi: 10.1136/bmjqs-2014-003821.