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Review article: Biomedical intelligence

Vol. 145 No. 5152 (2015)

Targeting the RAS pathway by mitogen-activated protein kinase inhibitors

  • Michael Kiessling
  • Gerhard Rogler
DOI
https://doi.org/10.4414/smw.2015.14207
Cite this as:
Swiss Med Wkly. 2015;145:w14207
Published
13.12.2015

Abstract

Targeting of oncogenic driver mutations with small-molecule inhibitors resulted in powerful treatment options for cancer patients in recent years. The RAS (rat sarcoma) pathway is among the most frequently mutated pathways in human cancer. Whereas targeting mutant Kirsten RAS (KRAS) remains difficult, mutant B rapidly accelerated fibrosarcoma (BRAF) kinase is an established drug target in cancer. Now data show that neuroblastoma RAS (NRAS) and even Harvey RAS (HRAS) mutations could be predictive markers for treatment with mitogen-activated protein kinase (MEK) inhibitors. This review discusses recent preclinical and clinical studies of MEK inhibitors in BRAF and RAS mutant cancer.

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