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Review article: Biomedical intelligence

Vol. 142 No. 0708 (2012)

Treatment of chronic hepatitis C genotype 1 with triple therapy comprising telaprevir or boceprevir

  • Darius Moradpour
  • Beat Müllhaupt
  • Swiss Association for the Study of the Liver
DOI
https://doi.org/10.4414/smw.2012.13516
Cite this as:
Swiss Med Wkly. 2012;142:w13516
Published
12.02.2012

Abstract

Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. Two first-generation protease inhibitors, telaprevir and boceprevir, have recently been approved for the treatment of chronic hepatitis C genotype 1. Triple therapy comprising pegylated interferon-α, ribavirin and telaprevir or boceprevir increases sustained virological response rates to ~70% and allows to shorten treatment duration in ~½ of treatment-naïve patients with chronic hepatitis C genotype 1. Sustained virological response rates in treatment-experienced patients depend on the response to previous treatment, ranging from >80% in previous relapsers to ~30% in previous null responders. These advances come at the expense of new adverse effects and increased cost. In addition, treatment of chronic hepatitis C will become more complex. In these times of changing medical practice, the present expert opinion statement by the Swiss Association for the Study of the Liver shall provide guidance on the treatment of chronic hepatitis C with triple therapy comprising telaprevir or boceprevir.

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