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Patterns of care and economic consequences of using bone-targeted agents for castration-sensitive prostate cancer patients with bone metastases to prevent skeletal-related events in Switzerland – the SAKK 95/16 prostate study
International guidelines state that bone-targeted agents such as denosumab or zoledronic acid at doses used for bone metastasis are not indicated for patients with metastatic castration-sensitive prostate cancer with bone metastases. Whereas denosumab has never been studied in this patient population, zoledronic acid has been shown to be ineffective in decreasing the risk for skeletal-related events. This study estimates the prevalence and economic consequences of real-world use of bone-targeted agents for mCSPC patients in Switzerland.
Guideline of the Swiss Society of Gynaecology and Obstetrics (SSGO) on acute and recurrent urinary tract infections in women, including pregnancy
This guideline from the Swiss Society of Gynaecology and Obstetrics provides quick answers for every day clinical questions concerning urinary tract infections, especially for obstetricians and gynaecologists.
Incidental findings during computed tomographic angiography diagnostic work-up in patients with arteriogenic erectile dysfunction
Erectile dysfunction (ED) has recently been identified as a predictor of generalised vascular disease and, besides the functional sexual impairment, symptoms of ED may be indicative of underlying risk factors or cardiovascular comorbidities.
Seminal vesicle sparing robotic radical prostatectomy – no different interpretation of postoperative PSA follow-up required?
The rationale of seminal vesicle sparing robotic radical prostatectomy is to spare nerves that are responsible for erectile function and close to the tips of the seminal vesicles. However, these remaining tips are known to produce prostate-specific antigen, which is measured for postoperative monitoring.
Does seminal vesicle-sparing robotic radical prostatectomy influence postoperative prostate-specific antigen measured with an ultrasensitive immunoassay?
The authors analysed whether sparing of the seminal vesicles during robotic radical prostatectomy affects oncological outcome in terms of ultrasensitive PSA nadir and biochemical recurrence as compared with standard robotic assisted laparoscopic radical prostatectomy.
Overuse of antimicrobial prophylaxis in low-risk patients undergoing transurethral resection of the prostate
Adherence to antimicrobial prophylaxis recommendations of the European Association of Urology effectively reduces infectious complications and resistance rates. The high frequency of antimicrobial resistance in urological patients may reflect inappropriate use of antimicrobial agents and prolonged prophylaxis.
Shared decision-making for prostate cancer screening and treatment: a systematic review of randomised controlled trials
Men facing prostate cancer screening and treatment need to make critical and highly preference-sensitive decisions that involve a variety of potential benefits and risks. Shared decision-making is considered fundamental for “preference-sensitive” medical decisions.
Arterial spin labelling may have advantages over functional magnetic resonance imaging when slow varying changes in brain function are investigated, as in this study in patients with chronic pelvic pain syndrome.
Biofilms on ureteral stents appear to be a key factor in the associated morbidity. Further research in this field seems to be worthwhile to reduce the morbidity associated with ureteral stenting.