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High-pressure balloon dilatation for the treatment of primary obstructive megaureter: is it the first line of treatment in children and infants?

Original article
Torino G, Roberti A, Brandigi E, Turrà F, Fonzone A, Di Iorio G
Swiss Med Wkly. 2021;151:w20513

The aim of this study was to evaluate the efficacy of high-pressure balloon dilatation (HPBD) as treatment of primary obstructive megaureter in paediatric patients. HPBD proved to be a safe, feasible and minimally invasive technique to treat primary obstructive megaureter with surgical criteria, even under 1 year of age. In comparison with standard surgery, HPBD has the advantages of being a less invasive procedure with no patient-age limitations. In our opinion, the HPBD may be utilised as  first-line treatment in the management of primary obstructive megaureter  in children, avoiding unnecessary bladder surgery in most cases. In any case, this technique does not influence conventional surgery in the case of failure.

Patterns of care and economic consequences of using bone-targeted agents for castration-sensitive prostate cancer patients with bone metastases to prevent skeletal-related events in Switzerland – the SAKK 95/16 prostate study

Original article
Stoffel ST, von Moos R, Thürlimann B, Cathomas R, Gillessen S, Zürrer-Härdi U, von Briel T, Anchisi S, Feller A, Schär C, Dietrich D, Schwenkglenks M, Lupatsch JE, Mark MT
Swiss Med Wkly. 2021;151:w20464

International guidelines state that bone-targeted agents such as denosumab or zoledronic acid at doses used for bone metastasis are not indicated for patients with metastatic castration-sensitive prostate cancer with bone metastases. Whereas denosumab has never been studied in this patient population, zoledronic acid has been shown to be ineffective in decreasing the risk for skeletal-related events. This study estimates the prevalence and economic consequences of real-world use of bone-targeted agents for mCSPC patients in Switzerland.

Guideline of the Swiss Society of Gynaecology and Obstetrics (SSGO) on acute and recurrent urinary tract infections in women, including pregnancy

Review article: Medical guidelines
Betschart C, Albrich WC, Brandner S, Faltin D, Kuhn A, Surbek D, Geissbuehler V
Swiss Med Wkly. 2020;150:w20236

This guideline from the Swiss Society of Gynaecology and Obstetrics provides quick answers for every day clinical questions concerning urinary tract infections, especially for obstetricians and gynaecologists.

Incidental findings during computed tomographic angiography diagnostic work-up in patients with arteriogenic erectile dysfunction

Original article
Schönhofen J, Mohan V, Schumacher MC, Bechir M, Keo HH, Schönhofen H, Joder T, Diehm C, Kalka C, Diehm N
Swiss Med Wkly. 2019;149:w20154

Erectile dysfunction (ED) has recently been identified as a predictor of generalised vascular disease and, besides the functional sexual impairment, symptoms of ED may be indicative of underlying risk factors or cardiovascular comorbidities.

Seminal vesicle sparing robotic radical prostatectomy – no different interpretation of postoperative PSA follow-up required?

Betschart P, Omlin A, Abt D
Swiss Med Wkly. 2018;148:w14698

The rationale of seminal vesicle sparing robotic radical prostatectomy is to spare nerves that are responsible for erectile function and close to the tips of the seminal vesicles. However, these remaining tips are known to produce prostate-specific antigen, which is measured for postoperative monitoring.

Does seminal vesicle-sparing robotic radical prostatectomy influence postoperative prostate-specific antigen measured with an ultrasensitive immunoassay?

Original article
Burkhardt O, Neuenschwander JE, John H, Randazzo M
Swiss Med Wkly. 2018;148:w14685

The authors analysed whether sparing of the seminal vesicles during robotic radical prostatectomy affects oncological outcome in terms of ultrasensitive PSA nadir and biochemical recurrence as compared with standard robotic assisted laparoscopic radical prostatectomy.

Overuse of antimicrobial prophylaxis in low-risk patients undergoing transurethral resection of the prostate

Original article
Bausch K, Roth JA, Seifert HH, Widmer AF
Swiss Med Wkly. 2018;148:w14594

Adherence to antimicrobial prophylaxis recommendations of the European Association of Urology effectively reduces infectious complications and resistance rates. The high frequency of antimicrobial resistance in urological patients may reflect inappropriate use of antimicrobial agents and prolonged prophylaxis.

Shared decision-making for prostate cancer screening and treatment: a systematic review of randomised controlled trials

Systematic review
Martínez-González NA, Plate A, Senn O, Markun S, Rosemann T, Neuner-Jehle S
Swiss Med Wkly. 2018;148:w14584

Men facing prostate cancer screening and treatment need to make critical and highly preference-sensitive decisions that involve a variety of potential benefits and risks. Shared decision-making is considered fundamental for “preference-sensitive” medical decisions.

Therapy-related longitudinal brain perfusion changes in patients with chronic pelvic pain syndrome

Original article
Weisstanner C, Mordasini L, Thalmann GN, Verma RK, Rummel C, Federspiel A, Kessler TM, Wiest R
Swiss Med Wkly. 2017;147:w14454

Arterial spin labelling may have advantages over functional magnetic resonance imaging when slow varying changes in brain function are investigated, as in this study in patients with chronic pelvic pain syndrome.

Biofilm formation on ureteral stents - Incidence, clinical impact, and prevention

Systematic review
Zumstein V, Betschart P, Albrich WC, Buhmann MT, Ren Q, Schmid HP, Abt D
Swiss Med Wkly. 2017;147:w14408

Biofilms on ureteral stents appear to be a key factor in the associated morbidity. Further research in this field seems to be worthwhile to reduce the morbidity associated with ureteral stenting.

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