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In the eye of the hurricane: the Swiss COVID-19 pandemic stepwise shutdown approach in organ donation and transplantation

Original article
Immer F, Benden C, Elmer A, Krügel N, Nyfeler S, Nebiker M, Wilhlem M, Hirzel C, National Committee for Organ Donation (CNDO), Medical Committee (CM) and Swisstransplant Infectious Diseases Working Group (STAI)
Swiss Med Wkly. 2020;150:w20447

The Swiss stepwise shutdown approach in organ donation and transplantation helped to maintain a limited national organ procurement and vital organ transplant activity, avoiding a complete nationwide shutdown of organ donation and transplant activity. 

SARS-CoV-2 / COVID-19 in patients on the Swiss national transplant waiting list

Original article
Benden C, Haile S, Kruegel N, Beyeler F, Aubert JD, Binet I, Golshayan D, Hadaya K, Mueller T, Parvex P, Immer F
Swiss Med Wkly. 2020;150:w20451

The impact of coronavirus disease 2019 (COVID-19) on patients listed for solid organ transplantation has not been systematically investigated to date. The authors of this study assessed occurrence and effects of infections with SARS-CoV-2 on patients on the Swiss national waiting list for solid organ transplantation.

Immunosuppression management in renal transplant recipients with normal-immunological risk: 10-year results from the Swiss Transplant Cohort Study

Original article
Krisl A, Stampf S, Hauri D, Binet I, Mueller T, Sidler D, Hadaya K, Golshayan D, Pascual M, Koller M, Dickenmann M, the Swiss Transplant Cohort Study (STCS)
Swiss Med Wkly. 2020;150:w20354

Primary maintenance immunosuppression with tacrolimus has displaced ciclosporin-based therapies. The tacrolimus-based immunosuppression therapy showed consistently better results across almost all assessed clinically relevant outcomes.

Electrolyte disorders in stable renal allograft recipients

Original article
Beilhack G, Lindner G, Funk GC, Monteforte R, Schwarz C
Swiss Med Wkly. 2020;150:w20366

Acid base and electrolyte disorders are frequently observed in stable renal allograft recipients, but are usually mild. A combination of two or more electrolyte abnormalities often occurs, although no predominant pattern of a unique combination of electrolyte disorder is recognizable.

First case of Cryptococcus gattii multilobar pneumonia in Switzerland and associated challenges

Original article
Colucci N, Teasca L, Riat A, Lazarevic V, Van Delden C, Berney T, Toso C, Neofytos D
Swiss Med Wkly. 2020;150:w20306

This case illustrates the potential complications of a cryptococcal infection in immunosuppressed hosts, despite timely diagnosis and appropriate antifungal therapy.

Paediatric end-stage renal disease and renal replacement therapy in Switzerland: survival and treatment trends over four decades

Original article
Maurer E, Neuhaus TJ, Weitz M, Kuehni CE, Laube GF
Swiss Med Wkly. 2020;150:w20300

Predictors of long-term employment among patients with cystic fibrosis undergoing lung transplantation

Original article
Radtke T, Königs A, Chen X, Braun J, Dressel H, Benden C
Swiss Med Wkly. 2020;150:w20286

Pre-transplant employment is the dominant factor influencing lung transplantation employment in people with cystic fibrosis. People with cystic fibrosis undergoing lung transplantation should be encouraged to work for as long as their health status permits. Professional reintegration after successful lung transplantation should be supported by a multi-disciplinary lung transplant team.

Fiftieth anniversary of the first heart transplantation in Switzerland in the context of the worldwide history of heart transplantation

Review article: Biomedical intelligence
Wilhelm MJ, Ruschitzka F, Flammer AJ, Bettex D, Turina MI, Maisano F
Swiss Med Wkly. 2020;150:w20192

To commemorate the 50th anniversary of the first heart transplantation in ­Switzerland, on 14 April 1969, this article reviews the history of the procedure worldwide and current challenges.

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Original article
Longchamp A, Meier RPH, Colucci N, Balaphas A, Orci LA, Nastasi A, Longchamp G, Moll S, Klauser A, Pascual M, Lazeyras F, Corpataux JM, Bühler L
Swiss Med Wkly. 2019;149:w20143

Transplantation of kidneys from deceased donors is associated with a high rate of postoperative renal dysfunction. During implantation, the kidney rewarms. This second warm ischaemia time is harmful, especially if prolonged.

Immunosuppressant therapeutic drug monitoring and trough level stabilisation after paediatric liver or kidney transplantation

Original article
Posfay-Barbe KM, Baudet H, McLin VA, Parvex P, Chehade H, Combescure C, Bonnabry P, Fonzo-Christe C
Swiss Med Wkly. 2019;149:w20156

Immunosuppressive therapy must be guided by therapeutic drug monitoring (TDM) in paediatric liver (LT) and kidney transplantation (KT) patients to prevent under- and overdosing, which have clinical consequences.

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