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First case of Cryptococcus gattii multilobar pneumonia in Switzerland and associated challenges

Original article
Colucci N, Teasca L, Riat A, Lazarevic V, Van Delden C, Berney T, Toso C, Neofytos D
Swiss Med Wkly. 2020;150:w20306

This case illustrates the potential complications of a cryptococcal infection in immunosuppressed hosts, despite timely diagnosis and appropriate antifungal therapy.

Paediatric end-stage renal disease and renal replacement therapy in Switzerland: survival and treatment trends over four decades

Original article
Maurer E, Neuhaus TJ, Weitz M, Kuehni CE, Laube GF
Swiss Med Wkly. 2020;150:w20300

Predictors of long-term employment among patients with cystic fibrosis undergoing lung transplantation

Original article
Radtke T, Königs A, Chen X, Braun J, Dressel H, Benden C
Swiss Med Wkly. 2020;150:w20286

Pre-transplant employment is the dominant factor influencing lung transplantation employment in people with cystic fibrosis. People with cystic fibrosis undergoing lung transplantation should be encouraged to work for as long as their health status permits. Professional reintegration after successful lung transplantation should be supported by a multi-disciplinary lung transplant team.

Fiftieth anniversary of the first heart transplantation in Switzerland in the context of the worldwide history of heart transplantation

Review article: Biomedical intelligence
Wilhelm MJ, Ruschitzka F, Flammer AJ, Bettex D, Turina MI, Maisano F
Swiss Med Wkly. 2020;150:w20192

To commemorate the 50th anniversary of the first heart transplantation in ­Switzerland, on 14 April 1969, this article reviews the history of the procedure worldwide and current challenges.

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Original article
Longchamp A, Meier RPH, Colucci N, Balaphas A, Orci LA, Nastasi A, Longchamp G, Moll S, Klauser A, Pascual M, Lazeyras F, Corpataux JM, Bühler L
Swiss Med Wkly. 2019;149:w20143

Transplantation of kidneys from deceased donors is associated with a high rate of postoperative renal dysfunction. During implantation, the kidney rewarms. This second warm ischaemia time is harmful, especially if prolonged.

Immunosuppressant therapeutic drug monitoring and trough level stabilisation after paediatric liver or kidney transplantation

Original article
Posfay-Barbe KM, Baudet H, McLin VA, Parvex P, Chehade H, Combescure C, Bonnabry P, Fonzo-Christe C
Swiss Med Wkly. 2019;149:w20156

Immunosuppressive therapy must be guided by therapeutic drug monitoring (TDM) in paediatric liver (LT) and kidney transplantation (KT) patients to prevent under- and overdosing, which have clinical consequences.

Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study

Original article
Lengwiler E, Stampf S, Zippelius A, Salati E, Zaman K, Schäfer N, Schardt J, Siano M, Hofbauer G, the Swiss Transplant Cohort Study
Swiss Med Wkly. 2019;149:w20078

There is a large body of evidence indicating that 4 to 5% of solid organ transplant recipients develop a malignancy after transplantation, which corresponds to an approximately two- to four-fold elevated risk compared to the general population.

Health-related quality of life and stress-related post-transplant trajectories of lung transplant recipients: a three-year follow-up of the Swiss Transplant Cohort Study

Original article
Bleisch B, Schuurmans MM, Klaghofer R, Benden C, Seiler A, Jenewein J, Psychosocial Interest Group, Swiss Transplant Cohort Study
Swiss Med Wkly. 2019;149:w20019

Lung transplantation provides a viable option for the survival of end-stage lung diseases. Besides survival as a clinical outcome measure, health-related quality of life and psychological distress have become important study outcomes.

The immune influence of a parabiosis model on tumour-bearing mice

Original article
Feng N, Luo JM, Guo X
Swiss Med Wkly. 2018;148:w14678

The occurrence and development of cancer cells in the body is a dynamic process of interaction between the immune system and the tumour cells. Whether tumour growth is promoted or suppressed in the parabiosis model is still unclear.

Adult onset haemophagocytic lymphohistiocytosis prognosis is affected by underlying disease: analysis of a single-institution series of 174 patients

Original article
Zhang Q, Li L, Zhu L, Zhu J, Yang X, Zhou D, Zheng Y, Zhu M, Xie M, Sun J, Li X, Wu Y, Wei Z, Xie W, Ye X
Swiss Med Wkly. 2018;148:w14641

Haemophagocytic lymphohistiocytosis is a rare clinical syndrome characterised by activation of the mononuclear phagocytic system, and often leads to progressive multiple organ failure. Haemophagocytic lymphohistiocytosis is diagnosed late by most physicians.

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