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Including adolescents of childbearing potential in clinical trials with possible exposure to teratogenic medication: a challenge for paediatricians and researchers
This article reviews how to address practical and ethical questions regarding minor adolescents of childbearing potential enrolled in a clinical trial that may involve teratogenic medication and offers a series of concrete advice and tools for dealing with problematic situations.
A 2019 Swiss Academy of Medical Science bulletin addressed the challenge of translational research: the enormous rift between basic scientific discoveries and their use in clinical therapies. The report termed this distance “the valley of death”. Strategies to apply implementation science methods to Swiss health research offer an excellent return on investment. Designing studies specifically to overcome translation barriers promises to remove years from the current research process.
The objective of this article is to review the interaction of data protection law and biomedical research with a predominant focus on the Swiss context.
Jurisdictional inquiries are an important means for researchers to clarify whether their project requires ethical oversight. However, this mixed-methods study has identified some difficulties in the interpretation of legal terms, which often reflect persistent structural issues that many other countries also face. More detailed guidance may be helpful to reduce the researchers’ uncertainties and ethics committees’ workloads in relation to jurisdictional inquiries.
Bayesian networks to identify potential high-risk multimorbidity and intervention clusters in inpatients: an explorative data mining study
Bayesian network analysis may be used as a tool to mine large healthcare databases in order to explore intervention targets for quality improvement programmes. However, the resulting associations should be substantiated in consecutive investigations using specific causal models.
Data-driven inference of the reproduction number for COVID-19 before and after interventions for 51 European countries
The authors present an online tool for the data-driven inference and quantification of uncertainties for the reproduction number, as well as the time points of interventions for 51 European countries. The results quantify the rate of the disease’s spread before and after interventions and provide a metric for the effectiveness of non-pharmaceutical interventions in different countries.
It is likely that there is only a limited time window for the optimisation of the proximity tracing app and promotion of substantial population uptake. It will be all the more important that research programmes allow data-driven, evidence-based optimisations, and information for the public about the benefits, harms and costs of proximity tracing apps.
Careful preparation of submission documents by the investigators and close adherence to formal and legal requirements have the potential to considerably optimise and expedite the ethics committee review process, and thus the commencement of the clinical research.
One in seven Swiss physicians has left patient care - results from a national cohort study from 1980-2009
Physician shortage is problematic, but the percentage of physicians who have left patient care in Switzerland is unclear.
The diagnostic diversity index can be seen as an indicator of diagnostic precision - the higher the degree of diversity, the better the diagnostic precision.