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Characteristics of emergency department presentations requiring consultation of the national Poisons Information Centre

Original article
Liakoni E, Berger F, Klukowska-Rötzler J, Kupferschmidt H, Haschke M, Exadaktylos AK
Swiss Med Wkly. 2019;149:w20164

According to data from European hospitals, about 1% of all emergency department (ED) admissions are related to poisoning. Poison information centres (PICs) can provide valuable support to ED personnel and help to optimise patient management in such cases.

Immunosuppressant therapeutic drug monitoring and trough level stabilisation after paediatric liver or kidney transplantation

Original article
Posfay-Barbe KM, Baudet H, McLin VA, Parvex P, Chehade H, Combescure C, Bonnabry P, Fonzo-Christe C
Swiss Med Wkly. 2019;149:w20156

Immunosuppressive therapy must be guided by therapeutic drug monitoring (TDM) in paediatric liver (LT) and kidney transplantation (KT) patients to prevent under- and overdosing, which have clinical consequences.

Describing adverse events in medical inpatients using the Global Trigger Tool

Original article
Grossmann N, Gratwohl F, Musy SN, Nielen NM, Simon M, Donzé J
Swiss Med Wkly. 2019;149:w20149

Improving patient safety in hospitals demands effective and reliable monitoring of adverse events (AEs). The most common method of assessing AEs is retrospective chart review; the Global Trigger Tool is a promising chart review method.

Targeting the Wnt signalling pathway in cancer: prospects and perils

Review article: Biomedical intelligence
Shaw HV, Koval A, Katanaev VL
Swiss Med Wkly. 2019;149:w20129

The Wnt pathway is not only involved in tumourigenesis and cell proliferation, but also contributes to chemoresistance and cancer stem cell propagation, responsible for tumour recurrence after therapy, metastasis and poor patient survival.

Drug prescription patterns, polypharmacy and potentially inappropriate medication in Swiss nursing homes: a descriptive analysis based on claims data

Original article
Schneider R, Reinau D, Schur N, Blozik E, Früh M, Signorell A, Meier CR, Schwenkglenks M
Swiss Med Wkly. 2019;149:w20126

Since drug prescribing plays a major role in nursing home settings, its optimisation has become a public-health issue worldwide. To date, comprehensive data on drug utilisation in Swiss nursing homes are lacking.

Prevalence of high-risk drug-drug interactions in paediatric inpatients: a retrospective, single-centre cohort analysis

Original article
Dieu LW, Leuppi-Taegtmeyer AB, van den Anker J, Trachsel D, Gotta V
Swiss Med Wkly. 2019;149:w20103

Drug-drug interaction (DDI) screening programmes aim to increase the safety of medication by issuing alerts based on the severity of DDIs. However, not all DDI alerts may be clinically relevant.

Editorial response regarding diversion of prescription and over-the-counter drugs in Switzerland

Viewpoint
Lessenger JE
Swiss Med Wkly. 2019;149:w20063

The diversion of prescription and over-the-counter medicines for recreational use is an ongoing, world-wide problem. This viewpoint article provides some possible ways to address it.

Emergency department presentations related to abuse of prescription and over-the-counter drugs in Switzerland: time trends, sex and age distribution

Original article
Scholz I, Schmid Y, Exadaktylos AK, Haschke M, Liechti ME, Liakoni E
Swiss Med Wkly. 2019;149:w20056

The European Drug Emergencies Network (Euro-DEN) Plus project has been collecting data on acute intoxications with recreational substances (illicit and prescription/OTC drugs) and emergency presentations across Europe since 2013.

Pharmacovigilance in ophthalmology in Switzerland: an analysis of the most frequently reported ocular adverse drug reactions within the last 25 years

Original article
Karrer JE, Giovannoni L, Kullak-Ublick GA, Weiler S
Swiss Med Wkly. 2019;149:w20085

Although systemic drugs can exert local effects on the eye, ophthalmology is a medical specialty with perhaps the fewest assessed adverse drug reactions (ADRs), representing a particular challenge in pharmacovigilance.

Nevirapine in HIV maintenance therapy – can “old drugs” survive in current HIV management?

Original article
Notter J, Bregenzer A, Vernazza P, Kahlert CR
Swiss Med Wkly. 2019;149:w20053

The authors present the results of a single centre strategy to offer the switch to a NVP-containing regimen and evaluate the potential role NVP could play in current antiretroviral treatment.

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