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Expert recommendation from the Swiss Amyloidosis Network (SAN) for systemic AL-amyloidosis

Review article: Medical guidelines
Schwotzer R, Flammer AJ, Gerull S, Pabst T, Arosio P, Averaimo M, Bacher VU, Bode P, Cavalli A, Concoluci A, Dirnhofer S, Djerbi N, Dobner SW, Fehr T, Garofalo M, Gaspert A, Heimgartner R, Hübers A, Jung HH, Kessler C, Knöpfel R, Laptseva N, Manka R, Mazzucchelli L, Meyer M, Mihaylova V, Monney P, Mylonas A, Nkoulou R, Pazhenkottil A, Pfister O, Rüfer A, Schmidt A, Seeger H, Stämpfli SF, Stirnimann G, Suter T, Théaudin M, Treglia G, Tzankov A, Vetter F, Zweier M, Gerber B
Swiss Med Wkly. 2020;150:w20364

These are the Swiss Amyloidosis Network recommendations which focus on diagnostic work-up and treatment of AL-amyloidosis. One aim of this meeting was to establish a consensus guideline regarding the diagnostic work-up and the treatment recommendations for systemic amyloidosis tailored to the Swiss health care system.

Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult

Original article
Othenin-Girard A, Regamey J, Lamoth F, Horisberger A, Glampedakis E, Epiney JB, Kuntzer T, de Leval L, Carballares M, Hurni CA, Rusca M, Pantet O, Di Bernardo S, Oddo M, Comte D, Piquilloud L
Swiss Med Wkly. 2020;150:w20387

Multisystem inflammatory syndrome associated with SARS-CoV-2 can occur in adults. The clinical presentation can include severe organ damage with features of incomplete or complete Kawasaki disease, including coronary aneurysm, as well as myocarditis-associated cardiogenic shock and also mononeuritis multiplex.

Concordance of tumour characteristics and survival clustering among pairs of first-degree relatives with breast cancer

Original article
Rapiti E, Tille JC, Fournier E, Saiji E, Weintraub D, Bouzourene H, Viassolo V, Bouchardy C, Chappuis PO, Benhamou S
Swiss Med Wkly. 2020;150:w20327

Family history is a known risk factor for breast cancer, but its prognostic value and the prognostic value of tumour characteristics in relation to family history has not been clearly established.

Clinical course of COVID-19 pneumonia in a patient undergoing pneumonectomy and pathology findings during the incubation period

Original article
Çınar HU, İnce Ö, Çelik B, Saltabaş F, Özbek M
Swiss Med Wkly. 2020;150:w20302

The case presented here represents an “incidental” sampling of a lung infected with SARS-CoV-2, as a result of surgery for lung cancer at a time when the lung infection did not produce symptoms. This gave the opportunity to examine the pathology of COVID-19 pneumonia during the incubation period.

Is antibody-dependent enhancement playing a role in COVID-19 pathogenesis?

Viewpoint
Negro F
Swiss Med Wkly. 2020;150:w20249

The pathogenesis of COVID-19 is currently believed to proceed via both directly cytotoxic and immune-mediated mechanisms. An additional mechanism facilitating viral cell entry and subsequent damage may involve the so-called antibody-dependent enhancement (ADE).

Non-invasive diagnosis of liver steatosis: ready for primetime?

Viewpoint
Goossens N
Swiss Med Wkly. 2019;149:w20108

The formal diagnosis of hepatic steatosis relies on liver histology based on a liver biopsy, which is an invasive procedure that is not required in the majority of cases. Due to the high prevalence of liver steatosis, in particular in the context of an increase in NAFLD incidence, there has been renewed interest in use of non-invasive tools to assess the presence of liver disease.

Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience

Original article
Baumeler S, Jochum W, Neuweiler J, Bergamin I, Semela D
Swiss Med Wkly. 2019;149:w20077

Accurate diagnosis and staging of non-alcoholic fatty liver disease are essential for its management. Controlled attenuation parameter is a new noninvasive measurement made during transient elastography to assess liver steatosis.

Hepatic manifestations of Wilson’s disease: 12-year experience in a Swiss tertiary referral centre

Original article
Vieira Barbosa J, Fraga M, Saldarriaga J, Hiroz P, Giostra E, Sempoux C, Ferenci P, Moradpour D
Swiss Med Wkly. 2018;148:w14699

Wilson’s disease is an inherited disorder of hepatic copper metabolism, leading to the accumulation of copper in the liver as well as the brain, cornea and other organs.

Motivational interviewing increases autopsy rates

Original article
Rosenberg I, Gierer B, Flury R, Battegay E, Balmer PE
Swiss Med Wkly. 2018;148:w14679

Autopsies are a crucial source of medical knowledge. Autopsy rates have decreased in Switzerland and many other countries. Communication between clinicians and the deceased’s sceptical relatives is crucial to obtain autopsy permission.

Synovial sarcoma: when epigenetic changes dictate tumour development

Review article: Biomedical intelligence
Riggi N, Cironi L, Stamenkovic I
Swiss Med Wkly. 2018;148:w14667

Synovial sarcoma accounts for 10 to 20% of all soft tissue sarcomas in the adolescent and young adult population and is the most common soft tissue sarcoma after rhabdomyosarcoma. Elucidation of the pathogenesis is needed to develop effective, mechanism-based therapeutic strategies.

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