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Non-invasive diagnosis of liver steatosis: ready for primetime?

Viewpoint
Goossens N
Swiss Med Wkly. 2019;149:w20108

The formal diagnosis of hepatic steatosis relies on liver histology based on a liver biopsy, which is an invasive procedure that is not required in the majority of cases. Due to the high prevalence of liver steatosis, in particular in the context of an increase in NAFLD incidence, there has been renewed interest in use of non-invasive tools to assess the presence of liver disease.

Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience

Original article
Baumeler S, Jochum W, Neuweiler J, Bergamin I, Semela D
Swiss Med Wkly. 2019;149:w20077

Accurate diagnosis and staging of non-alcoholic fatty liver disease are essential for its management. Controlled attenuation parameter is a new noninvasive measurement made during transient elastography to assess liver steatosis.

Hepatic manifestations of Wilson’s disease: 12-year experience in a Swiss tertiary referral centre

Original article
Vieira Barbosa J, Fraga M, Saldarriaga J, Hiroz P, Giostra E, Sempoux C, Ferenci P, Moradpour D
Swiss Med Wkly. 2018;148:w14699

Wilson’s disease is an inherited disorder of hepatic copper metabolism, leading to the accumulation of copper in the liver as well as the brain, cornea and other organs.

Motivational interviewing increases autopsy rates

Original article
Rosenberg I, Gierer B, Flury R, Battegay E, Balmer PE
Swiss Med Wkly. 2018;148:w14679

Autopsies are a crucial source of medical knowledge. Autopsy rates have decreased in Switzerland and many other countries. Communication between clinicians and the deceased’s sceptical relatives is crucial to obtain autopsy permission.

Synovial sarcoma: when epigenetic changes dictate tumour development

Review article: Biomedical intelligence
Riggi N, Cironi L, Stamenkovic I
Swiss Med Wkly. 2018;148:w14667

Synovial sarcoma accounts for 10 to 20% of all soft tissue sarcomas in the adolescent and young adult population and is the most common soft tissue sarcoma after rhabdomyosarcoma. Elucidation of the pathogenesis is needed to develop effective, mechanism-based therapeutic strategies.

Recommendations for genetic testing and counselling after sudden cardiac death: practical aspects for Swiss practice

Review article: Biomedical intelligence
Medeiros Domingo A, Bolliger S, Gräni C, Rieubland C, Hersch D, Asatryan B, Schyma C, Saguner A, Wyler D, Bhuiyan Z, Fellman F, Osculati AM, Ringger R, Fokstuen S, Sabatasso S, Wilhelm M, Michaud K, Swiss Working Group on Sudden Cardiac Death
Swiss Med Wkly. 2018;148:w14638

Genetic testing can reveal substrates for cardiomyopathies and channelopathies, as well as aortic diseases and premature atherosclerosis, which may explain some sudden cardiac deaths.

New treatment for non-Hodgkin B-cell lymphomas with a special focus on the impact of junctional adhesion molecules

Review article: Biomedical intelligence
Imhof BA, Matthes T
Swiss Med Wkly. 2017;147:w14487

B-cell non-Hodgkin lymphomas are are among the six most common cancer types in Switzerland. Five-year survival is approximately 55–75%.

Diagnosis and assessment of renal fibrosis: the state of the art

Review article: Biomedical intelligence
Berchtold L, Friedli I, Vallée JP, Moll S, Martin PY, de Seigneux S
Swiss Med Wkly. 2017;147:w14442

Evaluation of interstitial fibrosis is crucial to the assessment of prognosis and to guide therapy for most kidney diseases. However, how best to measure kidney fibrosis remains uncertain.

Current opinion: where are we in our understanding and treatment of osteoarthritis?

Review article: Biomedical intelligence
Poole AR
Swiss Med Wkly. 2016;146:w14340

Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting

Original article
Frontzek K, Lutz MI, Aguzzi A, Kovacs GG, Budka H
Swiss Med Wkly. 2016;146:w14287

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