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Swiss newborn screening for severe T and B cell deficiency with a combined TREC/KREC assay – management recommendations

Review article: Biomedical intelligence
Trück J, Prader S, Natalucci G, Hagmann C, Brotschi B, Kelly J, Bassler D, Steindl K, Rauch A, Baumgartner M, Fingerhut R, Hauri-Hohl M, Güngör T, Pachlopnik Schmid J, Berger C, Reichenbach J
Swiss Med Wkly. 2020;150:w20254

The recent introduction of newborn screening for severe primary T and B cell deficiencies in Switzerland allows rapid identification of patients with severe combined immunodeficiency (SCID). The authors outline the screening procedure currently performed in Switzerland and give recommendations for diagnostic evaluations and precautionary measures against infection in children with abnormal screening test results.

Deficiencies in paediatric research applications delaying ethics committee approval

Original article
Bergstraesser E, Nadal D, Özgü H, Kleist P
Swiss Med Wkly. 2020;150:w20267

Careful preparation of submission documents by the investigators and close adherence to formal and legal requirements have the potential to considerably optimise and expedite the ethics committee review process, and thus the commencement of the clinical research.

Prevalence of tuberculosis in migrant children in Switzerland and relevance of current screening guidelines

Original article
Boukamel M, Fougère Y, Gehri M, Suris JC, Rochat I, Miletto D, Kyrilli S, Fouriki A, Crisinel PA
Swiss Med Wkly. 2020;150:w20253

Screening migrant children ≥5 years of age for tuberculosis could confer a public health benefit even in the absence of other risk factors. The limit of tuberculin skin test positivity could be raised from ≥5 mm to ≥10 mm to decrease the rate of false-positive results.

Reasons for admission in asylum-seeking and non-asylum-seeking patients in a paediatric tertiary care centre

Original article
Gmünder M, Brandenberger J, Buser S, Pohl C, Ritz N
Swiss Med Wkly. 2020;150:w20252

In the last decade an increasing number of asylum-seeking children arrived in Europe and local healthcare systems have been challenged to adapt to their health needs. The aim of this study was to compare the spectrum of disease and management of asylum-seeking and non-asylum-seeking children requiring hospital admission.

Overlapping borders: limit of viability and late terminations of pregnancy – a retrospective multicentre observational study

Original article
Berger F, Bucher HU, Fauchère JC, Schulzke S, Berger TM
Swiss Med Wkly. 2020;150:w20186

This is a comprehensive study of late terminations of pregnancy between 22 0/7 and 27 6/7 weeks of gestation in Switzerland. Late terminations of pregnancy contribute significantly to mortality rates among extremely low gestational age newborns (ELGANs).

Neonatal red blood cell transfusion practices in Switzerland: national survey and review of international recommendations

Original article
Arlettaz Mieth R, Gosztonyi L, Hegemann I, Bassler D, Rüegger C
Swiss Med Wkly. 2020;150:w20178

Anaemia is a common problem in neonatal intensive care. The vast majority of extremely low birth weight infants (birth weight less than 1000 g) require numerous red blood cell transfusions during their neonatal period.

Prevalence of high-risk drug-drug interactions in paediatric inpatients: a retrospective, single-centre cohort analysis

Original article
Dieu LW, Leuppi-Taegtmeyer AB, van den Anker J, Trachsel D, Gotta V
Swiss Med Wkly. 2019;149:w20103

Drug-drug interaction (DDI) screening programmes aim to increase the safety of medication by issuing alerts based on the severity of DDIs. However, not all DDI alerts may be clinically relevant.

Late correction of tetralogy of Fallot in children

Original article
Heinisch PP, Guarino L, Hutter D, Bartkevics M, Erdoes G, Eberle B, Royo C, Rhissass J, Pfammatter JP, Carrel T, Kadner A
Swiss Med Wkly. 2019;149:w20096

Early repair of tetralogy of Fallot has many advantages, but patients in developing countries usually do not receive timely repair interventions.

Swiss paediatrician survey on complementary medicine

Original article
Huber BM, von Schoen-Angerer T, Hasselmann O, Wildhaber J, Wolf U
Swiss Med Wkly. 2019;149:w20091

In Switzerland, complementary medicine is officially recognised within the healthcare system and mainly practised in conjunction with conventional medicine. As in other countries, there is high demand for and use of complementary medicine with children.

Impact of co-amoxicillin-resistant Escherichia coli and Pseudomonas aeruginosa on the rate of infectious complications in paediatric complicated appendicitis

Original article
Andrey V, Crisinel PA, Prod'hom G, Croxatto A, Joseph JM
Swiss Med Wkly. 2019;149:w20055

Antibiotic choice for complicated appendicitis should address local antibiotic resistance patterns. We opted for co-amoxicillin in 2013. After that, the increasing prevalence of Pseudomonas aeruginosa challenged this choice.

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