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NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates

Original article
Rudolf von Rohr T, de Luca R, Bonnabry P, Pfister R, Fonzo-Christe C
Swiss Med Wkly. 2021;151:w20519

Drug prescription in neonatology is challenging. For hospitalised neonates, it is based largely on low-quality pharmacotherapeutic evidence from small clinical studies, and off-label drug use occurs in >85% of cases. Widely accepted guidelines are rare, leading to great variability in practice. NeoCheck is the first prescription-screening tool developed to optimise neonatal pharmacotherapy. 

High-pressure balloon dilatation for the treatment of primary obstructive megaureter: is it the first line of treatment in children and infants?

Original article
Torino G, Roberti A, Brandigi E, Turrà F, Fonzone A, Di Iorio G
Swiss Med Wkly. 2021;151:w20513

The aim of this study was to evaluate the efficacy of high-pressure balloon dilatation (HPBD) as treatment of primary obstructive megaureter in paediatric patients. HPBD proved to be a safe, feasible and minimally invasive technique to treat primary obstructive megaureter with surgical criteria, even under 1 year of age. In comparison with standard surgery, HPBD has the advantages of being a less invasive procedure with no patient-age limitations. In our opinion, the HPBD may be utilised as  first-line treatment in the management of primary obstructive megaureter  in children, avoiding unnecessary bladder surgery in most cases. In any case, this technique does not influence conventional surgery in the case of failure.

Parents’ intent to vaccinate against influenza during the COVID-19 pandemic in two regions in Switzerland

Original article
Seiler M, Goldman RD, Staubli G, Hoeffe J, Gualco G, Manzano S, part of the International COVID-19 Parental Attitude Study (COVIPAS) Group
Swiss Med Wkly. 2021;151:w20508

The COVID-19 pandemic resulted in a substantial increase of parents’ intention to vaccinate their children against influenza, especially in hard-hit “Latin” Switzerland. The Swiss government and public health organisations can leverage these regional results to promote influenza vaccination among children for the coming seasons.

Single embryo transfer in all infertile couples treated with assisted reproduction produces excellent results and avoids multiple births

Original article
De Geyter C
Swiss Med Wkly. 2021;151:w20499

The consequent adoption of a single embryo transfer significantly reduced the incidence of multiple births in the department of obstetrics and the number of prematurely born infants resulting from multiple pregnancies in the department of neonatology. Universal elective single embryo transfer is feasible in Switzerland, benefits infertile couples treated with assisted reproductive technology and reduces the number of multiple births in obstetrics and of newborn children hospitalised into neonatal care.

Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy

Original article
Grass B, Brotschi B, Hagmann C, Birkenmaier A, Schwendener K, Adams M, Kleber M, Swiss National Asphyxia and Cooling Register
Swiss Med Wkly. 2021;151:w20489

Short-term outcome indicators of seizures, arterial hypotension, infection and mortality showed significant differences in incidence between the centres. These data will help to establish benchmarks for the assessed outcome measures. Benchmarking is a continuous need with the ultimate goal of improving modifiable short-term outcomes in neonates with hypoxic-ischaemic encephalopathy.

Contemporary early results of late repair of tetralogy of Fallot in children: a single-centre case series

Original article
Mottier V, Prsa M
Swiss Med Wkly. 2021;151:w20491

Compared with the existing literature on complete late repair of tetralogy of Fallot in children, this study showed good early results with no mortality, similar rates of reintervention and valve-preserving surgery, higher ICU and hospital length of stay, higher incidence of significant residual right ventricular outflow tract stenosis, and lower incidence of significant pulmonary insufficiency. Repair with a transannular patch was a risk factor for significant residual right ventricular outflow tract stenosis and significant pulmonary insufficiency.

Iatrogenic events contributing to paediatric intensive care unit admission

Original article
Salvini R, Frey B
Swiss Med Wkly. 2021;151:w20414

In the case series presented here, the number of PICU admissions associated with iatrogenic events was significant and comparable to adult data on admission to ICU caused by iatrogenic events. The categories with most potential for improvement are nosocomial infections and the wrong management decisions / delayed diagnoses. Focused measures on these iatrogenic events may have a major impact on patient outcome, availability of PICU resources and healthcare costs.

Beware the inhaled steroids or corticophobia?

Review article: Biomedical intelligence
Gidaris DK, Stabouli S, Bush A
Swiss Med Wkly. 2021;151:w20450

Inhaled corticosteroids have been the cornerstone of atopic, allergic asthma management for more than half a century. They have side effects (as does every medication), but they have transformed the control of asthma and saved many lives since their introduction. The current review revisits local and systemic side effects of inhaled corticosteroids and explores the prevalence and nature of parental fears (“corticophobia”) in different parts of the world. The empathetic physician treating asthma should bear in mind the impact of parental concerns on the management of this potentially life-threatening disease and try to dispel myths at every opportunity by emphasising the well-established benefits and excellent safety profile of inhaled corticosteroids.

A retrospective epidemiological study of paediatric femoral fractures

Original article
Valaikaite R, Tabard-Fougère A, Steiger C, Samara E, Dayer R, Ceroni D
Swiss Med Wkly. 2020;150:w20360

Femoral fracture is a significant major trauma in children and adolescents, sometimes resulting in serious complications. This study aimed to determine the epidemiology of femoral fractures and to define associated injuries and mortality incidence in a pediatric population below 16 years old.

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