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Including adolescents of childbearing potential in clinical trials with possible exposure to teratogenic medication: a challenge for paediatricians and researchers

Review article: Medical guidelines
Michaud PA, Diezi M, Guihard L, Jacot-Guillarmod M, Kleist P, Sprumont D, Wenger P
Swiss Med Wkly. 2020;150:w20333

This article reviews how to address practical and ethical questions regarding minor adolescents of childbearing potential enrolled in a clinical trial that may involve teratogenic medication and offers a series of concrete advice and tools for dealing with problematic situations.

PedAMINES: a disruptive mHealth app to tackle paediatric medication errors

Review article: Biomedical intelligence
Ehrler F, Siebert JN
Swiss Med Wkly. 2020;150:w20335

Medication errors are among the most common medical adverse events and an important cause of patient morbidity and mortality, affecting millions of people worldwide each year. This problem is especially acute in paediatric settings, where most drugs given intravenously to children are provided in vials prepared for the adult population.

Neonatal transport in Switzerland: a retrospective single-centre analysis – quo vadis?

Original article
Leemann T, Bernet V, Grass B, Hagmann C
Swiss Med Wkly. 2020;150:w20308

The high proportion of urgent transfers emphasises the need for an efficient neonatal transport system and dedicated neonatal transport teams staffed by members with training in neonatal transport and expertise in handling neonatal emergencies.

Do fathers care about their own immunisation status? The Child-Parent-Immunisation Survey and a review of the literature

Original article
Erb ML, Erlanger TE, Heininger U
Swiss Med Wkly. 2020;150:w20289

This is the first study to analyse the complete immunisation status of fathers of young children. It is often incomplete with potentially missed opportunities for updating vaccinations during recent physician consultations. 

Paediatric end-stage renal disease and renal replacement therapy in Switzerland: survival and treatment trends over four decades

Original article
Maurer E, Neuhaus TJ, Weitz M, Kuehni CE, Laube GF
Swiss Med Wkly. 2020;150:w20300

Swiss newborn screening for severe T and B cell deficiency with a combined TREC/KREC assay – management recommendations

Review article: Biomedical intelligence
Trück J, Prader S, Natalucci G, Hagmann C, Brotschi B, Kelly J, Bassler D, Steindl K, Rauch A, Baumgartner M, Fingerhut R, Hauri-Hohl M, Güngör T, Pachlopnik Schmid J, Berger C, Reichenbach J
Swiss Med Wkly. 2020;150:w20254

The recent introduction of newborn screening for severe primary T and B cell deficiencies in Switzerland allows rapid identification of patients with severe combined immunodeficiency (SCID). The authors outline the screening procedure currently performed in Switzerland and give recommendations for diagnostic evaluations and precautionary measures against infection in children with abnormal screening test results.

Deficiencies in paediatric research applications delaying ethics committee approval

Original article
Bergstraesser E, Nadal D, Özgü H, Kleist P
Swiss Med Wkly. 2020;150:w20267

Careful preparation of submission documents by the investigators and close adherence to formal and legal requirements have the potential to considerably optimise and expedite the ethics committee review process, and thus the commencement of the clinical research.

Prevalence of tuberculosis in migrant children in Switzerland and relevance of current screening guidelines

Original article
Boukamel M, Fougère Y, Gehri M, Suris JC, Rochat I, Miletto D, Kyrilli S, Fouriki A, Crisinel PA
Swiss Med Wkly. 2020;150:w20253

Screening migrant children ≥5 years of age for tuberculosis could confer a public health benefit even in the absence of other risk factors. The limit of tuberculin skin test positivity could be raised from ≥5 mm to ≥10 mm to decrease the rate of false-positive results.

Reasons for admission in asylum-seeking and non-asylum-seeking patients in a paediatric tertiary care centre

Original article
Gmünder M, Brandenberger J, Buser S, Pohl C, Ritz N
Swiss Med Wkly. 2020;150:w20252

In the last decade an increasing number of asylum-seeking children arrived in Europe and local healthcare systems have been challenged to adapt to their health needs. The aim of this study was to compare the spectrum of disease and management of asylum-seeking and non-asylum-seeking children requiring hospital admission.

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