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Concordance of tumour characteristics and survival clustering among pairs of first-degree relatives with breast cancer
Family history is a known risk factor for breast cancer, but its prognostic value and the prognostic value of tumour characteristics in relation to family history has not been clearly established.
This expert opinion statement by the Swiss Association for the Study of the Liver reviews the current state of HCC management and provides recommendations adapted to the health care environment in Switzerland.
Swiss newborn screening for severe T and B cell deficiency with a combined TREC/KREC assay – management recommendations
The recent introduction of newborn screening for severe primary T and B cell deficiencies in Switzerland allows rapid identification of patients with severe combined immunodeficiency (SCID). The authors outline the screening procedure currently performed in Switzerland and give recommendations for diagnostic evaluations and precautionary measures against infection in children with abnormal screening test results.
Swiss experience of atezolizumab for platinum-pretreated urinary tract carcinoma: the SAUL study in real-world practice
Atezolizumab is an approved therapy for urothelial carcinoma based on results from phase II and III trials. The global SAUL study evaluated atezolizumab in a broader patient population more representative of real-world populations.
Cancer cells are dependent on a few driver genes for the constitutive activation of the signalling pathways which aid cellular proliferation. Targeting oncogenic-dependent genes has met with success, as demonstrated in several cancer types.
Treatment sequence in patients with neuroendocrine tumours: a nationwide multicentre, observational analysis of the Swiss neuroendocrine tumour registry
In recent years, several treatment modalities have proved to be effective in the treatment of neuroendocrine tumours. However, there is currently no consensus on the sequence in which these options are best used.
Recent advancements in sequencing technology, including low-volume and single-cell sequencing, have led us to gain some fascinating new insights that may require us to reflect and adjust our understanding of cancer biology.
Cost effectiveness of pembrolizumab vs chemotherapy as first-line treatment for metastatic NSCLC that expresses high levels of PD-L1 in Switzerland
Pembrolizumab programmed death-1 (PD-1) inhibitor is indicated for treatment of patients with previously untreated metastatic NSCLC with a PD-L1 tumour proportion score (TPS) ≥50%. Its cost effectiveness for this indication has not previously been evaluated in Switzerland.
Impact of treatment decision algorithms on treatment costs in recurrent glioblastoma: a health economic study
Recurrent glioblastoma (GBM) is a disease with poor prognosis for which there is no established standard therapy. A recent survey among Swiss neuro-oncology centres has shown considerable differences in treatment recommendations.
The programmed death-1 (PD-1) pathway serves as a checkpoint to limit T-cell mediated immune responses. Blocking the PD-1 receptor on T cells with monoclonal antibodies results in T-cell activation and proliferation and can induce a potent immunotherapeutic antitumour effect.