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Glycaemic patterns in healthy elderly individuals and in those with impaired glucose metabolism – exploring the relationship with nonglycaemic variables

Original article
Medina Escobar P, Sakem B, Risch L, Risch M, Grebhardt C, Nydegger UE, Stanga Z
Swiss Med Wkly. 2019;149:w20163

This study relates the glycation gap to lipid metabolism, low grade inflammation as evidenced by high-sensitivity C-reactive protein, and kidney function as estimated by glomerular filtration rates.

Rapid point-of-care HCV RNA quantification in capillary whole blood for diagnosing chronic HCV infection, monitoring treatment and detecting reinfection

Original article
Bregenzer A, Warmann N, Ottiger C, Fux CA
Swiss Med Wkly. 2019;149:w20137

Reliable rapid hepatitis C virus (HCV) antibody tests are available, but there is need for optimising viraemia detection. Rapid point-of-care capillary HCV RNA quantification could remove barriers to chronic hepatitis C diagnosis and treatment.

Biomarkers in cardiovascular medicine: towards precision medicine

Review article: Biomedical intelligence
Gualandro DM, Twerenbold R, Boeddinghaus J, Nestelberger T, Puelacher C, Müller C
Swiss Med Wkly. 2019;149:w20125

Antimicrobial resistance trends in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis urinary isolates from Switzerland: retrospective analysis of data from a national surveillance network over an 8-year period (2009–2016)

Original article
Zanichelli V, Huttner A, Harbarth S, Kronenberg A, Huttner B, Swiss Centre for Antibiotic Resistance (ANRESIS)
Swiss Med Wkly. 2019;149:w20110

Guidelines on urinary tract infection (UTI) now recommend nitrofurantoin and fosfomycin as first-line options for lower UTI in women and discourage the use of quinolones because of the potential collateral damage in terms of the selection of drug-resistant organisms.

Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform

Review article: Biomedical intelligence
Egli A, Blanc DS, Greub G, Keller PM, Lazarevic V, Lebrand A, Leib S, Neher RA, Perreten V, Ramette A, Schrenzel J, Stephan R, Wagner K, Wuethrich D, Xenarios I
Swiss Med Wkly. 2018;148:w14693

The introduction of a country-wide molecular surveillance database aims to  increase the overall whole genome sequencing data quality and establish a molecular surveillance platform for selected pathogens.

Does seminal vesicle-sparing robotic radical prostatectomy influence postoperative prostate-specific antigen measured with an ultrasensitive immunoassay?

Original article
Burkhardt O, Neuenschwander JE, John H, Randazzo M
Swiss Med Wkly. 2018;148:w14685

The authors analysed whether sparing of the seminal vesicles during robotic radical prostatectomy affects oncological outcome in terms of ultrasensitive PSA nadir and biochemical recurrence as compared with standard robotic assisted laparoscopic radical prostatectomy.

Time trends of positivity rates from foodborne pathogen testing in Switzerland, 2003 to 2012

Original article
Bless PJ, Schmutz C, Sartori K, Mäusezahl D
Swiss Med Wkly. 2017;147:w14569

Notification rates for Salmonella and Campylobacter originate from positive test ­results reported to the National Notification System for Infectious Diseases. Consequently, notification rates do not directly correspond to the disease burden among the population.

Costs and benefits of diagnostic testing: four ways to improve patient care by purposive use of in vitro diagnostics

Review article: Biomedical intelligence
Binder C, Schmid M, Dieterle T, Schäfer HH
Swiss Med Wkly. 2017;147:w14546

Implementing changes to the current utilisation of in-vitro diagnostic will be necessary to provide broad, cost-efficient, state-of-the-art healthcare in the future.

Ultrasound indications for maternal STORCH testing in pregnancy

Original article
Voekt CA, Rinderknecht T, Hirsch HH, Blaich A, Hösli IM
Swiss Med Wkly. 2017;147:w14534

Fetal abnormalities found on ultrasonography lead to a variety of diagnostic procedures, including a panel of tests to detect possible maternal STORCH infections.

Identification of a MAFB mutation in a patient with multicentric carpotarsal osteolysis

Original article
Zhuang L, Adler S, Aeberli D, Villiger PM, Trueb B
Swiss Med Wkly. 2017;147:w14529

The transcription factor MAFB appears to negatively regulate progenitor cell differentiation into osteoclasts. Mutations in MAFB, as found in multicentric carpo­tarsal osteo­lysis, might release the block of osteoclast differentiation.

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