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D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?

Original article
Breakey N, Escher R
Swiss Med Wkly. 2020;150:w20293

The authors present the case of a patient who was diagnosed with a pulmonary thrombotic complication during inpatient care for COVID-19. The haemostasis parameters, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19.

Copeptin-based diagnosis of diabetes insipidus

Review article: Biomedical intelligence
Refardt J, Christ-Crain M
Swiss Med Wkly. 2020;150:w20237

With the establishment of copeptin, a stable and reliable surrogate marker for arginine vasopressin, diagnosis of the polyuria-polydipsia syndrome has been newly evaluated.

Uranium exposure of the Swiss population based on 24-hour urinary excretion

Original article
Jenny-Burri J, Blanc A, Aubert R, Haldimann M, Zürcher U, Burnier M, Paccaud F, Bochud M, Dudler V
Swiss Med Wkly. 2020;150:w20207

Important regional differences in uranium exposure exist because of varying uranium concentrations in soil, water and food. Comprehensive data on the exposure of the general population to uranium is, however, scarce.

Thromboprophylaxis and laboratory monitoring for in-hospital patients with COVID-19 - a Swiss consensus statement by the Working Party Hemostasis

Special article
Casini A, Alberio L, Angelillo-Scherrer A, Fontana P, Gerber B, Graf L, Hegemann I, Korte W, Kremer Hovinga JA, Lecompte T, Martinez M, Nagler M, Studt JD, Tsakiris D, Wuillemin W, Asmis L
Swiss Med Wkly. 2020;150:w20247

Based on the available literature and published recommendations from international societies, the Working Party on Hemostasis (Swiss Society of Hematology) has prepared recommendations for pharmacological thromboprophylaxis in COVID-19 patients in the acute setting.

Glycaemic patterns in healthy elderly individuals and in those with impaired glucose metabolism – exploring the relationship with nonglycaemic variables

Original article
Medina Escobar P, Sakem B, Risch L, Risch M, Grebhardt C, Nydegger UE, Stanga Z
Swiss Med Wkly. 2019;149:w20163

This study relates the glycation gap to lipid metabolism, low grade inflammation as evidenced by high-sensitivity C-reactive protein, and kidney function as estimated by glomerular filtration rates.

Rapid point-of-care HCV RNA quantification in capillary whole blood for diagnosing chronic HCV infection, monitoring treatment and detecting reinfection

Original article
Bregenzer A, Warmann N, Ottiger C, Fux CA
Swiss Med Wkly. 2019;149:w20137

Reliable rapid hepatitis C virus (HCV) antibody tests are available, but there is need for optimising viraemia detection. Rapid point-of-care capillary HCV RNA quantification could remove barriers to chronic hepatitis C diagnosis and treatment.

Biomarkers in cardiovascular medicine: towards precision medicine

Review article: Biomedical intelligence
Gualandro DM, Twerenbold R, Boeddinghaus J, Nestelberger T, Puelacher C, Müller C
Swiss Med Wkly. 2019;149:w20125

Antimicrobial resistance trends in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis urinary isolates from Switzerland: retrospective analysis of data from a national surveillance network over an 8-year period (2009–2016)

Original article
Zanichelli V, Huttner A, Harbarth S, Kronenberg A, Huttner B, Swiss Centre for Antibiotic Resistance (ANRESIS)
Swiss Med Wkly. 2019;149:w20110

Guidelines on urinary tract infection (UTI) now recommend nitrofurantoin and fosfomycin as first-line options for lower UTI in women and discourage the use of quinolones because of the potential collateral damage in terms of the selection of drug-resistant organisms.

Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform

Review article: Biomedical intelligence
Egli A, Blanc DS, Greub G, Keller PM, Lazarevic V, Lebrand A, Leib S, Neher RA, Perreten V, Ramette A, Schrenzel J, Stephan R, Wagner K, Wuethrich D, Xenarios I
Swiss Med Wkly. 2018;148:w14693

The introduction of a country-wide molecular surveillance database aims to  increase the overall whole genome sequencing data quality and establish a molecular surveillance platform for selected pathogens.

Does seminal vesicle-sparing robotic radical prostatectomy influence postoperative prostate-specific antigen measured with an ultrasensitive immunoassay?

Original article
Burkhardt O, Neuenschwander JE, John H, Randazzo M
Swiss Med Wkly. 2018;148:w14685

The authors analysed whether sparing of the seminal vesicles during robotic radical prostatectomy affects oncological outcome in terms of ultrasensitive PSA nadir and biochemical recurrence as compared with standard robotic assisted laparoscopic radical prostatectomy.

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