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Oral antibiotic therapy in people who inject drugs (PWID) with bacteraemia

Review article: Biomedical intelligence
Martinez AE, Scheidegger C, Bättig V, Erb S
Swiss Med Wkly. 2020;150:w20259

Treatment of bacteraemia in people who inject drugs remains very complex, and an interdisciplinary approach is essential in order to select the best therapy for this vulnerable group of patients.

The well-being of Swiss general internal medicine residents

Original article
Zumbrunn B, Stalder O, Limacher A, Ballmer PE, Bassetti S, Battegay E, Beer JH, Brändle M, Genné D, Hayoz D, Henzen C, Huber LC, Petignat PA, Reny JL, Vollenweider P, Aujesky D
Swiss Med Wkly. 2020;150:w20255

Approximately 20% of Swiss general internal medicine residents appear to have a reduced well-being and many show signs of distress or have career choice regret. Having few hours of rewarding work and a high number of working hours were the most important modifiable predictors of reduced well-being. Healthcare organisations have an ethical responsibility to implement interventions to improve physician well-being.

D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?

Original article
Breakey N, Escher R
Swiss Med Wkly. 2020;150:w20293

The authors present the case of a patient who was diagnosed with a pulmonary thrombotic complication during inpatient care for COVID-19. The haemostasis parameters, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19.

Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save lives – current situation and perspectives

Tamburello A, Marando M
Swiss Med Wkly. 2020;150:w20264

During the SARS-CoV-2 pandemic different treatments are being explored and tested, in the absence of official management protocols. Some show initial promise, many have been tried out without sound biological bases. Plasma and H-IVIG of recovered patients are a tried and tested approach that could prove helpful in the short term.

Recommendations on the use of anticoagulants for the treatment of patients with heparin-induced thrombocytopenia in Switzerland

Review article: Medical guidelines
Alberio L, Angelillo-Scherrer A, Asmis L, Casini A, Fontana P, Graf L, Hegemann I, Kremer Hovinga JA, Korte W, Lecompte T, Martinez M, Nagler M, Studt JD, Tsakiris DA, Wuillemin W
Swiss Med Wkly. 2020;150:w20210

Management of acute heparin-­induced thrombocytopenia currently involves cessation of heparin exposure, and inhibition of coagulation with an anticoagulant other than heparin.

Individualised nutritional support in medical inpatients – a practical guideline

Review article: Medical guidelines
Baumgartner A, Kägi-Braun N, Tribolet P, Gomes F, Stanga Z, Schuetz P
Swiss Med Wkly. 2020;150:w20204

Recent trials have demonstrated that early, individualised nutritional support improves clinical outcomes of patients. Hence, we must now think of clinical nutrition as a medical treatment that has a measurable impact on disease development and recovery.

Code status discussions in medical inpatients: results of a survey of patients and physicians

Original article
Becker C, Künzli N, Perrig S, Beck K, Vincent A, Widmer M, Thommen E, Schaefert R, Bassetti S, Hunziker S
Swiss Med Wkly. 2020;150:w20194

Code status discussions are useful for understanding patients’ preferences in the case of a cardiac/pulmonary arrest. These discussions can also provide patients with a basis for informed decision-making regarding life-sustaining treatment.

Atrial fibrillation for internists: current practice

Review article: Biomedical intelligence
Meyre P, Conen D, Osswald S, Kühne M, Meyer-Zürn C
Swiss Med Wkly. 2020;150:w20196

Atrial fibrillation is the most common sustained cardiac arrhythmia in clinical practice, and its prevalence is expected to increase in the near future.

Glycaemic patterns in healthy elderly individuals and in those with impaired glucose metabolism – exploring the relationship with nonglycaemic variables

Original article
Medina Escobar P, Sakem B, Risch L, Risch M, Grebhardt C, Nydegger UE, Stanga Z
Swiss Med Wkly. 2019;149:w20163

This study relates the glycation gap to lipid metabolism, low grade inflammation as evidenced by high-sensitivity C-reactive protein, and kidney function as estimated by glomerular filtration rates.

The glory of the age is the wisdom of grey hair: association of physician appearance with outcomes in hospitalised medical patients – an observational study

Original article
Haubitz-Eschelbach A, Durmisi M, Haubitz S, Kutz A, Mueller B, Greenwald JL, Schuetz P
Swiss Med Wkly. 2019;149:w20162

The physical appearance of a physician may influence patients’ perception of the physicians’ quality of care. There is a lack of studies investigating whether physician appearance is indeed associated with patient satisfaction and mortality.

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