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“Liquid biopsy” in lymphoma types lacking leukaemic involvement refers to the accessing of tumour-specific DNA in plasma, serum or other body fluids, without the necessity of an invasive tumour biopsy.
The occurrence and development of cancer cells in the body is a dynamic process of interaction between the immune system and the tumour cells. Whether tumour growth is promoted or suppressed in the parabiosis model is still unclear.
Over the last few years, there have been many changes in the management of patients with follicular lymphoma, resulting in improvements in progression-free survival and quality of life.
Diffuse large B-cell lymphoma chemotherapy reveals a combined immunodeficiency syndrome in cartilage hair hypoplasia
Cartilage hair hypoplasia is a rare autosomal recessive ribosomopathy related to a mutation in the ribonuclease mitochondrial RNA processing (RMRP) gene, which encodes the mitochondrial portion of the RNA processing endonuclease.
Management of anticoagulation-associated bleeding has become more challenging as the number of available drugs increases: vitamin K antagonists, unfractionated and low molecular heparin, as well as the newer direct oral anticoagulants targeting either factor Xa or thrombin.
Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland
Post-transplant lymphoproliferative disorder (PTLD) is a potentially life-threatening complication of immunosuppression and oncogenic viral infections.
Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997–2016
Federal regulations in Switzerland have made it mandatory to maintain a registry including all heamatopietic stem cell transplants performed in the country.
Monobodies might be a valuable addition to the armamentarium of targeted cancer drugs, given their unique properties and superior selectivity, and could usefully be combined with other targeted cancer therapeutics.
Accurate evaluation and monitoring of iron overload has major implications regarding prognosis and quality of life. MRI can evaluate the presence of iron overload and aid the detection of underlying conditions.
The need to understand normal or malignant human cell development and disease heterogeneity, and to investigate novel therapeutic strategies, supported the development of “humanised” mouse models.