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Liquid biopsy in tissue-born lymphomas

Review article: Biomedical intelligence
Spina V, Rossi D
Swiss Med Wkly. 2019;149:w14709

“Liquid biopsy” in lymphoma types lacking leukaemic involvement refers to the accessing of tumour-specific DNA in plasma, serum or other body fluids, without the necessity of an invasive tumour biopsy.

The immune influence of a parabiosis model on tumour-bearing mice

Original article
Feng N, Luo JM, Guo X
Swiss Med Wkly. 2018;148:w14678

The occurrence and development of cancer cells in the body is a dynamic process of interaction between the immune system and the tumour cells. Whether tumour growth is promoted or suppressed in the parabiosis model is still unclear.

Diagnosis and treatment of follicular lymphoma: an update

Review article: Biomedical intelligence
Bargetzi M, Baumann R, Cogliatti S, Dietrich PY, Duchosal M, Goede J, Hitz F, Konermann C, Lohri A, Mey U, Novak U, Papachristofilou A, Stenner F, Taverna C, Zander T, Renner C
Swiss Med Wkly. 2018;148:w14635

Over the last few years, there have been many changes in the management of patients with follicular lymphoma, resulting in improvements in progression-free survival and quality of life.

Diffuse large B-cell lymphoma chemotherapy reveals a combined immunodeficiency syndrome in cartilage hair hypoplasia

Original article
Nguyen A, Martin Silva N, de Boysson H, Damaj G, Aouba A
Swiss Med Wkly. 2018;148:w14606

Cartilage hair hypoplasia is a rare autosomal recessive ribosomopathy related to a mutation in the ribonuclease mitochondrial RNA processing (RMRP) gene, which encodes the mitochondrial portion of the RNA processing endonuclease.

How I manage patients with anticoagulation-associated bleeding or urgent surgery

Review article: Biomedical intelligence
Sauter TC, Eberle B, Wuillemin WA, Thiele T, Angelillo-Scherrer A, Exadaktylos AK, Erdoes G, Cuker A, Nagler M
Swiss Med Wkly. 2018;148:w14598

Management of anticoagulation-associated bleeding has become more challenging as the number of available drugs increases: vitamin K antagonists, unfractionated and low molecular heparin, as well as the newer direct oral anticoagulants targeting either factor Xa or thrombin.

Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland

Original article
Steiner R, Kridel R, Giostra E, McKee T, Achermann R, Mueller N, Manuel O, Dickenmann M, Schuurmans MM, de Leval L, Fehr T, Tinguely M, Binet I, Cogliatti S, Haralamvieva E, Koller M, the Swiss Transplant Cohort Study (STCS), Dietrich PY
Swiss Med Wkly. 2018;148:w14596

Post-transplant lymphoproliferative disorder (PTLD) is a potentially life-threatening complication of immunosuppression and oncogenic viral infections.

Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997–2016

Original article
Passweg JR, Baldomero H, Ansari M, Baerlocher GM, Bargetzi M, Chalandon Y, Duchosal MA, Gerull S, Güngör T, Halter JP, Heim D, Hess U, Leibundgut K, Masouridi-Levrat S, Müller A, Nair G, Pabst T, Renner C, Schmidt A, Stussi G, Nicoloso de Faveri G, Schanz U, for the Swiss Blood Stem Cell Transplantation Group (SBST)
Swiss Med Wkly. 2018;148:w14589

Federal regulations in Switzerland have made it mandatory to maintain a registry including all heamatopietic stem cell transplants performed in the country.

Monobodies as possible next-generation protein therapeutics – a perspective

Review article: Biomedical intelligence
Hantschel O
Swiss Med Wkly. 2017;147:w14545

Monobodies might be a valuable addition to the armamentarium of targeted ­cancer drugs, given their unique properties and superior selectivity, and could usefully be combined with other targeted cancer therapeutics.

Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload

Review article: Biomedical intelligence
Ruefer A, Bapst C, Benz R, Bremerich J, Cantoni N, Infanti L, Samii K, Schmid M, Vallée JP
Swiss Med Wkly. 2017;147:w14550

Accurate evaluation and monitoring of iron overload has major implications regarding prognosis and quality of life. MRI can evaluate the presence of iron overload and aid the detection of underlying conditions.

Humanised mouse models for haematopoiesis and infectious diseases

Review article: Biomedical intelligence
Lysenko V, McHugh D, Behrmann L, Rochat MA, Wilk CM, Kovtonyuk L, Bourquin JP, Münz C, Manz MG, Speck R, Theocharides A
Swiss Med Wkly. 2017;147:w14516

The need to understand normal or malignant human cell development and disease heterogeneity, and to investigate novel therapeutic strategies, supported the development of “humanised” mouse models.

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