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Drug prescription in neonatology is challenging. For hospitalised neonates, it is based largely on low-quality pharmacotherapeutic evidence from small clinical studies, and off-label drug use occurs in >85% of cases. Widely accepted guidelines are rare, leading to great variability in practice. NeoCheck is the first prescription-screening tool developed to optimise neonatal pharmacotherapy.
Gamma Knife surgery for recurrent or persistent Cushing disease: long-term results and evaluation of biological effective dose in a series of 26 patients
Gamma Knife radiosurgery offers high rates of tumour control and endocrine remission on a long-term basis for ACTH-secreting pituitary adenomas. In this small series, higher BED values appeared to be associated with better endocrine remission rates.
Supplementation of the population during the COVID-19 pandemic with vitamins and micronutrients – how much evidence is needed?
Before answering the question regarding usefulness of supplementation of the population during a pandemic with vitamins and micronutrients as a public health strategy to reduce COVID-19 associated morbidity, it is important to define the level of evidence that is needed.
Acetylcholinesterase inhibitors combined with memantine for moderate to severe Alzheimer's disease: a meta-analysis
The clinical efficacy and safety of combination therapy with acetylcholinesterase inhibitors (AChEI) and memantine compared to AChEIs or memantine alone in patients with Alzheimer’s disease is inconclusive.
Rationale and methods of an observational study to support the design of a nationwide surgical registry: the MIDAS study
Surgical registries are becoming increasingly popular, and Swiss legislation requires data on therapeutic outcome quality. The Swiss Association of Surgeons has agreed on a first minimum data set for a nationwide registry.
Caffeine is a central nervous system stimulant occurring naturally in some foods and used to treat primary apnoea in premature babies. However, high caffeine intake can be harmful, and caffeine is transmitted into breastmilk.
The aim of video documentation during labour is to provide an observational tool for obstetric care by midwives and obstetricians, with the opportunity for evaluation and education afterwards.
Further consideration needs to be given to how regulations can be revised in a way that ensures that healthcare improvement activities using the same quality data in Switzerland are not either overregulated on one side or completely without control on the other.
Adaptation of cost-effectiveness analyses to a single country: the case of bariatric surgery for obesity and overweight
There is a relatively broad international literature on the cost effectiveness of bariatric surgery, but no systematic reviews that examine the transferability of international cost-effectiveness results for Switzerland or another single country.
Shared decision-making for prostate cancer screening and treatment: a systematic review of randomised controlled trials
Men facing prostate cancer screening and treatment need to make critical and highly preference-sensitive decisions that involve a variety of potential benefits and risks. Shared decision-making is considered fundamental for “preference-sensitive” medical decisions.