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To test or not to test, and how … copeptin, please advise!

Viewpoint
Rutishauser J
Swiss Med Wkly. 2020;150:w20292

The differential diagnosis of the polyuria-polydipsia syndrome has been notoriously cumbersome, often involving some modified form of the indirect water deprivation test. Furthermore, published vasopressin ranges for the various forms of diabetes insipidus overlap; and reliable assays, tedious and time consuming as they are, never found their way into clinical routine. Now, the introduction of a routine-proof assay for copeptin, the biochemically stable C-terminal glycopeptide segment of the vasopressin prohormone, paved the way out of this stalemate.

Secondary hyperparathyroidism: recurrence after total parathyroidectomy with autotransplantation

Original article
Steffen L, Moffa G, Müller PC, Oertli D
Swiss Med Wkly. 2019;149:w20160

If drug therapy for secondary hyperparathyroidism (sHPTH) fails, total parathyroidectomy with autotransplantation of parathyroid tissue into the forearm (PTX-AT) is the most widely used procedure, but high recurrence rates are reported.

Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

Original article
Kocak MZ, Aktas G, Erkus E, Yis OM, Duman TT, Atak BM, Savli H
Swiss Med Wkly. 2019;149:w20139

Neuregulin-4 is a cytokine with many functions primarily produced by fat tissue. It is associated with body fat mass, insulin resistance, impaired glucose metabolism, obesity, non-alcoholic fatty liver disease, type 2 diabetes mellitus and metabolic syndrome.

Molecular imaging for neuroendocrine tumours

Review article: Biomedical intelligence
Antwi K, Nicolas G, Wild D, Christ E
Swiss Med Wkly. 2019;149:w20017

Considerable progress has been made over the last decades in the diagnosis of NET with new tracers. In addition, the successful administration of these molecules with radioisotopes, which have positron emitting properties, has been extensively and successfully explored.

Multidisciplinary approach for risk-oriented treatment of low-risk papillary thyroid cancer in Switzerland

Viewpoint
Zulewski H, Giovanella L, Bilz S, Christ E, Haldemann A, Steinert H, Weidner S, Oertli D, Triponez F, Clerici T, Minder A, Dettmer M, Komminoth P
Swiss Med Wkly. 2019;149:w14700

With the intention to find a common view on the management of patients with low-risk papillary thyroid cancer (PTC), a multidisciplinary working group was initiated by the Swiss Society for Endocrinology and Diabetes and endorsed by the Swiss Society for Nuclear Medicine and the working group of Swiss Endocrine Surgeons.

Clinical presentation of 54 patients with endogenous hyperinsulinaemic hypoglycaemia: a neurological chameleon (observational study)

Original article
Valente LG, Antwi K, Nicolas GP, Wild D, Christ E
Swiss Med Wkly. 2018;148:w14682

Important causes of endogenous hyperinsulinaemic hypoglycaemia (EHH) in adult patients are insulinoma and adult nesidioblastosis. Data on main symptoms in EHH are scarce and controversial.

Quality and cost considerations in hyponatraemic patients needing hospitalisation

Original article
Althaus AE, Krapf R
Swiss Med Wkly. 2018;148:w14662

Hyponatraemia is the most common electrolyte disorder encountered in hospitalised patients and has an impact on outcome and survival. However, the risk factors are not yet sufficiently known.

Adenoma size and postoperative IGF-1 levels predict surgical outcomes in acromegaly patients: results of the Swiss Pituitary Registry (SwissPit)

Original article
Kempf J, Schmitz A, Meier A, Delfs N, Mueller B, Fandino J, Schuetz P, Berkmann S
Swiss Med Wkly. 2018;148:w14653

So far, there is no standard set of prognostic parameters for patients diagnosed with acromegaly that helps to predict treatment outcomes, and might help to optimise initial treatment decisions and frequencies of follow-up visits.

Craniopharyngioma – a chronic disease

Viewpoint
Müller H
Swiss Med Wkly. 2018;148:w14548

As surgical expertise has a proven impact on post-treatment morbidity, medical societies should establish criteria of adequate professional expertise for surgical treatment of craniopharyngioma.

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