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Marfan syndrome and related connective tissue disorders in the current era in Switzerland in 103 patients: medical and surgical management and impact of genetic testing

Original article
Bombardieri E, Rohrbach M, Greutmann M, Matyas G, Weber R, Radulovic J, Fasnacht Boillat M, Linka A, De Pasquale G, Bonassin F, Attenhofer Jost CH
Swiss Med Wkly. 2020;150:w20189

Marfan syndrome (MFS) and related connective tissue disorders (CTDs) are increasingly recognised. Genetic testing has greatly improved the diagnostic outcome/power over the last two decades.

Atrial fibrillation for internists: current practice

Review article: Biomedical intelligence
Meyre P, Conen D, Osswald S, Kühne M, Meyer-Zürn C
Swiss Med Wkly. 2020;150:w20196

Atrial fibrillation is the most common sustained cardiac arrhythmia in clinical practice, and its prevalence is expected to increase in the near future.

Plaque vulnerability in patients with high- and moderate-grade carotid stenosis – comparison of plaque features on MRI with histopathological findings

Original article
Tapis P, El-Koussy M, Hewer E, Mono ML, Reinert M
Swiss Med Wkly. 2020;150:w20174

Plaque vulnerability plays an important role in determining the risk of subsequent cerebrovascular events in patients with carotid stenosis. Plaque morphology magnetic resonance imaging (MRI) can be used to assess plaque vulnerability.

Fiftieth anniversary of the first heart transplantation in Switzerland in the context of the worldwide history of heart transplantation

Review article: Biomedical intelligence
Wilhelm MJ, Ruschitzka F, Flammer AJ, Bettex D, Turina MI, Maisano F
Swiss Med Wkly. 2020;150:w20192

To commemorate the 50th anniversary of the first heart transplantation in ­Switzerland, on 14 April 1969, this article reviews the history of the procedure worldwide and current challenges.

Duration of pharmacological thromboprophylaxis after outpatient endovenous laser ablation: a propensity score-matched analysis

Original article
Keo HH, Spinedi L, Staub D, Diehm N, Holtz D, Broz P, Regli C, Uthoff H
Swiss Med Wkly. 2019;149:w20166

Many centres in Europe, including several in Switzerland, use pharmacological thromboprophylaxis after thermal ablation of varicose veins. However, the optimal duration of pharmacological thromboprophylaxis is currently not defined.

Role of imaging in primary prevention: calcium score is a robust and cost-efficient risk modifier

Yakupoglu HY, Gräni C
Swiss Med Wkly. 2019;149:w20183

Subclinical atherosclerosis, assessed by imaging, is associated with outcome. Imaging has the potential to enable providers to better tailor preventive therapy towards patient risk stratification compared to traditional risk scores.

First in Switzerland: concomitant off-pump transapical transcatheter aortic valve implantation and mitral valve reconstruction with the NeoChord system

Original article
Ntinopoulos V, Tüller D, Bernheim A, Papadopoulos N, Haeussler A, Matter-Ensner S, Eberli F, Dzemali O
Swiss Med Wkly. 2019;149:w20168

Older and polymorbid patients with multivalvular heart disease exhibit high peri­operative morbidity and mortality when treated with conventional surgery. Minimally invasive concomitant procedures are, however, possible.

Sonographic assessment of carotid atherosclerosis: preferred risk indicator for future cardiovascular events?

Review article: Biomedical intelligence
Romanens M, Sudano I, Adams A, Schober EA
Swiss Med Wkly. 2019;149:w20142

Many patients reaching hospital with a first ischaemic event are classified as low-risk subjects by risk calculators. Direct visualisation of atherosclerosis may therefore be warranted in order to reclassify subjects according to their individual risk.

Outcomes during and after the use of the wearable cardioverter-defibrillator in a tertiary-care and a regional hospital in Switzerland

Original article
Kovacs B, Reek S, Saguner AM, Krasniqi N, Eriksson U, Duru F
Swiss Med Wkly. 2019;149:w20136

Careful patient selection for wearable cardioverter-defibrillator (WCD) use is crucial, but unfortunately very little information from randomised controlled trials is available to guide clinical decision-making.

Biomarkers in cardiovascular medicine: towards precision medicine

Review article: Biomedical intelligence
Gualandro DM, Twerenbold R, Boeddinghaus J, Nestelberger T, Puelacher C, Müller C
Swiss Med Wkly. 2019;149:w20125

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