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Identifying cancer driver genes from functional genomics screens

Original article
Togar T, Desai S, Mishra R, Terwadkar P, Ramteke M, Ranjan M, Kawle D, Sahoo B, Pal A, Upadhyay P, Dutt A
Swiss Med Wkly. 2020;150:w20195

Cancer cells are dependent on a few driver genes for the constitutive activation of the signalling pathways which aid cellular proliferation. Targeting oncogenic-dependent genes has met with success, as demonstrated in several cancer types.

Importance of osteocyte-mediated regulation of bone remodelling in inflammatory bone disease

Review article: Biomedical intelligence
Intemann J, De Gorter DJJ, Naylor AJ, Dankbar B, Wehmeyer C
Swiss Med Wkly. 2020;150:w20187

Continuous bone remodelling is required to replace old bone tissue and to repair bone micro-cracks. In adults it has been estimated that 10% of bone is replaced every year and that this is crucial for maintenance of a healthy skeleton.

Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

Original article
Kocak MZ, Aktas G, Erkus E, Yis OM, Duman TT, Atak BM, Savli H
Swiss Med Wkly. 2019;149:w20139

Neuregulin-4 is a cytokine with many functions primarily produced by fat tissue. It is associated with body fat mass, insulin resistance, impaired glucose metabolism, obesity, non-alcoholic fatty liver disease, type 2 diabetes mellitus and metabolic syndrome.

The role of autophagy in HER2-targeted therapy

Review article: Biomedical intelligence
Janser FA, Tschan MP, Langer R
Swiss Med Wkly. 2019;149:w20138

The HER2 oncogene is overexpressed in different tumour types and drugs specifically targeting it have been successfully used in cancer therapy. Resistance to these drugs ultimately occurs. In this context autophagy was reported to be upregulated.

Biomarkers in cardiovascular medicine: towards precision medicine

Review article: Biomedical intelligence
Gualandro DM, Twerenbold R, Boeddinghaus J, Nestelberger T, Puelacher C, Müller C
Swiss Med Wkly. 2019;149:w20125

Targeting the Wnt signalling pathway in cancer: prospects and perils

Review article: Biomedical intelligence
Shaw HV, Koval A, Katanaev VL
Swiss Med Wkly. 2019;149:w20129

The Wnt pathway is not only involved in tumourigenesis and cell proliferation, but also contributes to chemoresistance and cancer stem cell propagation, responsible for tumour recurrence after therapy, metastasis and poor patient survival.

Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity

Review article: Biomedical intelligence
Noutsios GT, Sharma S
Swiss Med Wkly. 2019;149:w20104

Management of chronic rhinosinusitis and asthma must be jointly carried out as one functional entity.

Design and evaluation of a multi-epitope assembly peptide vaccine against Acinetobacter baumannii infection in mice

Original article
Ren S, Guan L, Dong Y, Wang C, Feng L, Xie Y
Swiss Med Wkly. 2019;149:w20052

Multi-epitope assembly peptides, which contain B-cell epitopes, T-cell epitopes or other specific residues, have been proved to be promising vaccine candidates against several pathogens in animal models.

Extracellular matrix: a new player in memory maintenance and psychiatric disorders

Review article: Biomedical intelligence
Bach D, Brown SA, Kleim B, Tyagarajan S
Swiss Med Wkly. 2019;149:w20060

Significant strides have been made in developing and refining psychotherapeutic treatments. However, there is significant room to improve them, and they may benefit from innovations such as extracellular matrix modification.

Designing artificial senses: steps from physiology to clinical implementation

Review article: Biomedical intelligence
Pérez Fornos A, Van de Berg R, Sommerhalder J, Guinand N
Swiss Med Wkly. 2019;149:w20061

The goal of this review is to highlight the multiple challenges involved in the development of sensory neuroprostheses, the current state of the technology, and to briefly discuss future clinical and research prospects.

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