Default

Allergy and immunology

Anaesthesia

Basic research

Cardiovascular medicine

Complementary medicine and alternative therapies

Critical care / intensive care

Dentistry / oral medicine

Dermatology

Emergency medicine

Endocrinology

Epidemiology

Ethics

Evidence-based medicine

Gastroenterology

Genetics

Geriatric medicine / aging

Haematology / blood transfusion

Health economics

Health policy

History of medicine

Infectious diseases

Internal medicine

Laboratory medicine

Medical education

Medical informatics

Neurology

Nursing

Nutrition and metabolism

Obstetrics and gynaecology

Occupational and environmental medicine

Oncology

Ophthalmology

Organisation of health care

Otolaryngology / head and neck surgery

Paediatrics

Palliative care

Pathology

Patient-physician relationship

Pharmacology and therapeutics

Primary care, family medicine

Psychiatry and psychotherapy

Psychosomatics

Public health

Quality of care

Radiology

Rehabilitation medicine

Renal medicine

Respiratory medicine

Rheumatology

Sexual medicine

Sports medicine

Statistics and research methods

Surgery

Transplantation

Travel medicine

Urology

Ops! No article found. Reset filter

A pitfall in estimating the effective reproductive number Rt for COVID-19

Viewpoint
Petermann M, Wyler D
Swiss Med Wkly. 2020;150:w20307

The effective reproductive number Rt of COVID-19 is determined indirectly from data that are only incompletely known. Approaches based on reconstructing these data by sampling time lags from suitable distributions introduce noise effects that can result in distorted estimates of Rt. This, in turn, may lead to misleading interpretations of the efficacy of the various measures taken to limit COVID-19 transmission.

Unexpected liaisons between old cytokines and new deadly virus

Viewpoint
Beretta A
Swiss Med Wkly. 2020;150:w20315

Researchers in Italy have not only identified new unexpected liaisons between old cytokines and the new coronavirus that open the way to the use in COVID-19 of drugs already approved for other diseases, but they have also provided valuable indications on how to better prepare ourselves to face a possible second wave of infection.

Insulin under the influence of light

Review article: Biomedical intelligence
Ursino G, Coppari R
Swiss Med Wkly. 2020;150:w20273

Recent evidence suggests that photic inputs regulate diurnal variations in the insulin sensitivity of metabolically relevant tissues via a previously unrecognised mechanism involving the ventromedial hypothalamic nucleus. Therefore, understanding the mechanisms underlying photic control of insulin action is of paramount medical importance.

The cellular prion protein beyond prion diseases

Review article: Biomedical intelligence
Manni G, Lewis V, Senesi M, Spagnolli G, Fallarino F, Collins SJ, Mouillet-Richard S, Biasini E
Swiss Med Wkly. 2020;150:w20222

The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases, has recently been implicated in the pathogenesis of other neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. This article provides an overview of what is known about the role of PrPC beyond prion disorders and discusses the potential implications of targeting this protein in different diseases.

Identifying cancer driver genes from functional genomics screens

Original article
Togar T, Desai S, Mishra R, Terwadkar P, Ramteke M, Ranjan M, Kawle D, Sahoo B, Pal A, Upadhyay P, Dutt A
Swiss Med Wkly. 2020;150:w20195

Cancer cells are dependent on a few driver genes for the constitutive activation of the signalling pathways which aid cellular proliferation. Targeting oncogenic-dependent genes has met with success, as demonstrated in several cancer types.

Importance of osteocyte-mediated regulation of bone remodelling in inflammatory bone disease

Review article: Biomedical intelligence
Intemann J, De Gorter DJJ, Naylor AJ, Dankbar B, Wehmeyer C
Swiss Med Wkly. 2020;150:w20187

Continuous bone remodelling is required to replace old bone tissue and to repair bone micro-cracks. In adults it has been estimated that 10% of bone is replaced every year and that this is crucial for maintenance of a healthy skeleton.

Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

Original article
Kocak MZ, Aktas G, Erkus E, Yis OM, Duman TT, Atak BM, Savli H
Swiss Med Wkly. 2019;149:w20139

Neuregulin-4 is a cytokine with many functions primarily produced by fat tissue. It is associated with body fat mass, insulin resistance, impaired glucose metabolism, obesity, non-alcoholic fatty liver disease, type 2 diabetes mellitus and metabolic syndrome.

The role of autophagy in HER2-targeted therapy

Review article: Biomedical intelligence
Janser FA, Tschan MP, Langer R
Swiss Med Wkly. 2019;149:w20138

The HER2 oncogene is overexpressed in different tumour types and drugs specifically targeting it have been successfully used in cancer therapy. Resistance to these drugs ultimately occurs. In this context autophagy was reported to be upregulated.

Biomarkers in cardiovascular medicine: towards precision medicine

Review article: Biomedical intelligence
Gualandro DM, Twerenbold R, Boeddinghaus J, Nestelberger T, Puelacher C, Müller C
Swiss Med Wkly. 2019;149:w20125

Targeting the Wnt signalling pathway in cancer: prospects and perils

Review article: Biomedical intelligence
Shaw HV, Koval A, Katanaev VL
Swiss Med Wkly. 2019;149:w20129

The Wnt pathway is not only involved in tumourigenesis and cell proliferation, but also contributes to chemoresistance and cancer stem cell propagation, responsible for tumour recurrence after therapy, metastasis and poor patient survival.

Verpassen Sie keinen Artikel!

close