Topic Collection Search
Allergy and immunology
Complementary medicine and alternative therapies
Critical care / intensive care
Dentistry / oral medicine
Geriatric medicine / aging
Haematology / blood transfusion
History of medicine
Legal and forensic medicine
Nutrition and metabolism
Obstetrics and gynaecology
Occupational and environmental medicine
Organisation of health care
Otolaryngology / head and neck surgery
Pharmacology and therapeutics
Primary care, family medicine
Psychiatry and psychotherapy
Quality of care
Statistics and research methods
Cancer cells are dependent on a few driver genes for the constitutive activation of the signalling pathways which aid cellular proliferation. Targeting oncogenic-dependent genes has met with success, as demonstrated in several cancer types.
Continuous bone remodelling is required to replace old bone tissue and to repair bone micro-cracks. In adults it has been estimated that 10% of bone is replaced every year and that this is crucial for maintenance of a healthy skeleton.
Neuregulin-4 is a cytokine with many functions primarily produced by fat tissue. It is associated with body fat mass, insulin resistance, impaired glucose metabolism, obesity, non-alcoholic fatty liver disease, type 2 diabetes mellitus and metabolic syndrome.
The HER2 oncogene is overexpressed in different tumour types and drugs specifically targeting it have been successfully used in cancer therapy. Resistance to these drugs ultimately occurs. In this context autophagy was reported to be upregulated.
The Wnt pathway is not only involved in tumourigenesis and cell proliferation, but also contributes to chemoresistance and cancer stem cell propagation, responsible for tumour recurrence after therapy, metastasis and poor patient survival.
Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity
Management of chronic rhinosinusitis and asthma must be jointly carried out as one functional entity.
Design and evaluation of a multi-epitope assembly peptide vaccine against Acinetobacter baumannii infection in mice
Multi-epitope assembly peptides, which contain B-cell epitopes, T-cell epitopes or other specific residues, have been proved to be promising vaccine candidates against several pathogens in animal models.
Significant strides have been made in developing and refining psychotherapeutic treatments. However, there is significant room to improve them, and they may benefit from innovations such as extracellular matrix modification.
The goal of this review is to highlight the multiple challenges involved in the development of sensory neuroprostheses, the current state of the technology, and to briefly discuss future clinical and research prospects.