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Immunosuppressant therapeutic drug monitoring and trough level stabilisation after paediatric liver or kidney transplantation

Original article
Posfay-Barbe KM, Baudet H, McLin VA, Parvex P, Chehade H, Combescure C, Bonnabry P, Fonzo-Christe C
Swiss Med Wkly. 2019;149:w20156

Immunosuppressive therapy must be guided by therapeutic drug monitoring (TDM) in paediatric liver (LT) and kidney transplantation (KT) patients to prevent under- and overdosing, which have clinical consequences.

A simple guide to the interpretation of the significance of the association of a disease with a particular HLA allele

Review article: Biomedical intelligence
Winchester R
Swiss Med Wkly. 2019;149:w20128

The impressive survival advantage of the adaptive immune system comes at the cost of autoimmunity and autoimmune disease because of the self-selected character of the adaptive immune system’s T cell repertoires.

Behçet’s syndrome: clinical presentation and prevalence in Switzerland

Original article
Villiger RA, Stefanski AL, Grobéty V, Adler S, Villiger PM
Swiss Med Wkly. 2019;149:w20072

Behçet’s syndrome is a rare systemic autoimmune/autoinflammatory disease. In Switzerland there are no published data regarding the prevalence of Behçet’s syndrome, its manifestations or its management.

Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity

Review article: Biomedical intelligence
Noutsios GT, Sharma S
Swiss Med Wkly. 2019;149:w20104

Management of chronic rhinosinusitis and asthma must be jointly carried out as one functional entity.

Design and evaluation of a multi-epitope assembly peptide vaccine against Acinetobacter baumannii infection in mice

Original article
Ren S, Guan L, Dong Y, Wang C, Feng L, Xie Y
Swiss Med Wkly. 2019;149:w20052

Multi-epitope assembly peptides, which contain B-cell epitopes, T-cell epitopes or other specific residues, have been proved to be promising vaccine candidates against several pathogens in animal models.

Development of a novel class of interleukin-2 immunotherapies for metastatic cancer

Review article: Biomedical intelligence
Boyman O, Arenas-Ramirez N
Swiss Med Wkly. 2019;149:w14697

Owing to its different but proven mode of action, interleukin-2 immunotherapy could complement many anticancer approaches, including immune checkpoint inhibitors, adoptive cell transfer regimens and vaccination.

Spirometry and provocation tests for vocal fold dysfunction diagnosis: a retrospective case series

Original article
Taramarcaz P, Seebach JD, Motteli L, Benaïm C, Schwitzguebel AJP
Swiss Med Wkly. 2018;148:w14692

Vocal cord dysfunction is characterised by paradoxical inspiratory laryngeal motion and is often misdiagnosed as asthma. Diagnosis is difficult, because laryngo­scopy is positive only during symptomatic episodes or provocation tests.

The immune influence of a parabiosis model on tumour-bearing mice

Original article
Feng N, Luo JM, Guo X
Swiss Med Wkly. 2018;148:w14678

The occurrence and development of cancer cells in the body is a dynamic process of interaction between the immune system and the tumour cells. Whether tumour growth is promoted or suppressed in the parabiosis model is still unclear.

The clinical benefit of imaging in the diagnosis and treatment of giant cell arteritis

Review article: Biomedical intelligence
Berger CT, Sommer G, Aschwanden M, Staub D, Rottenburger C, Daikeler T
Swiss Med Wkly. 2018;148:w14661

The manifestations of giant cell arteritis can be variable. About a third of large-vessel giant cell arteritis patients have no sonographic evidence of temporal vasculitis, and more than half have normal histology of the temporal artery.

Diffuse large B-cell lymphoma chemotherapy reveals a combined immunodeficiency syndrome in cartilage hair hypoplasia

Original article
Nguyen A, Martin Silva N, de Boysson H, Damaj G, Aouba A
Swiss Med Wkly. 2018;148:w14606

Cartilage hair hypoplasia is a rare autosomal recessive ribosomopathy related to a mutation in the ribonuclease mitochondrial RNA processing (RMRP) gene, which encodes the mitochondrial portion of the RNA processing endonuclease.

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