Autophagy and coronavirus infection – a Trojan horse or Achilles heel?

Many of the more promising compounds currently investigated in clinical trials are autophagy modulators, thus substantiating the need for an understanding of how coronaviruses interact with and utilise components of the autophagy pathway.

Distribution of low quality filtering facepiece respirators during the COVID-19 pandemic: an independent analysis of the situation in Switzerland

The demand for FFP respirators exceeded the supply capacity from established suppliers of the Swiss market. New production and import channels emerged, as did the number of poor-quality FFP respirators. FFP respirators remaining in stocks should be checked for conformity before being used, or eliminated and replaced if quality does not meet standards.

Laparoscopic liver resection: a single-centre experience

In the last two decades laparoscopic liver resection has developed dramatically. This study aimed to describe the experience and the results of laparoscopic liver resection at a single centre over 12 years.

Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission

ADR-related readmissions constituted a considerable part of short-term emergency readmissions. Despite being a relevant cause for rehospitalisation, only a minority of the ADRs were reported to the regulatory authorities. 

Risk factors for peritonsillar abscess in streptococcus A-negative tonsillitis: a case control study

The Centor criteria, as well as C-reactive protein and white blood cell count, have a low discriminatory performance, and the FeverPAIN score is not useful in identifying patients at risk for peritonsillar abscess in group A haemolytic streptococcus-negative tonsillitis. 

Real-world effectiveness and safety of glecaprevir/pibrentasvir therapy in patients with chronic hepatitis C virus infection in Switzerland

In the era of pangenotypic treatment regimens against hepatitis C virus infection, data from postmarketing observational studies are crucial to better understand the treatment patterns used in specific countries and treatment outcomes under real-life conditions.

Research projects in human genetics in Switzerland: analysis of research protocols submitted to cantonal ethics committees in 2018

This analysis provides a full national overview of genetic research dossiers pertaining to clinical and nonclinical trials, and to further-use research projects submitted for approval to ethics committees in Switzerland in 2018 .

Haemophagocytic lymphohistiocytosis and liver failure-induced massive hyperferritinaemia in a male COVID-19 patient

The authors present the case of a 58-year-old man with the unique combination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and, later on, haemophagocytic lymphohistiocytosis admitted to the intensive care unit.