The pathogenesis of COVID-19 is currently believed to proceed via both directly cytotoxic and immune-mediated mechanisms. An additional mechanism facilitating viral cell entry and subsequent damage may involve the so-called antibody-dependent enhancement (ADE).
Little is known at the moment about specific immune mechanisms that would work against SARS-CoV-2, although such knowledge is expected to play a vital role. In this context, a particular focus has to be given to the human leucocyte antigen system that governs our adaptive immunity.
At first sight, surgery appears to be only peripherally affected by the COVID.19 pandemic. However, the surgical department plays a key role in the response to this crisis. This article aims to provide a blueprint for a general surgery department’s response to this current pandemic crisis and also future events of similar magnitude.
Like many other countries around the world, Iran is contending with the COVID-19 epidemic, but with the additional burden of international sanctions on supplies of medicines and medical equipment.
This article reviews the associations that have been best documented between markers at classical HLA genes and six of the most prevalent infectious diseases, and discusses this in a population genetics and evolutionary perspective.
In 2018, Switzerland introduced a completely revised version of its national outcomes reference framework for the undergraduate medical curriculum. This paper describes the process put in place at a national level for its implementation.
Recent trials have demonstrated that early, individualised nutritional support improves clinical outcomes of patients. Hence, we must now think of clinical nutrition as a medical treatment that has a measurable impact on disease development and recovery.
Important regional differences in uranium exposure exist because of varying uranium concentrations in soil, water and food. Comprehensive data on the exposure of the general population to uranium is, however, scarce.
MD-PhD programmes throughout the world provide a platform for medical trainees to commit to a physician-scientist career, qualifying with both a medical degree (MD, or equivalent) and Doctor of Philosophy (PhD).
The findings presented here suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.
Since 1987, based on a standardised questionnaire that has evolved over the years, all Swiss cardiology centres are asked to report yearly aggregate data on the number and type of percutaneous cardiac procedures performed.
Information about the prevalence and characteristics of patients who are taking or receiving opioids and consult an emergency department (ED) may be useful in increasing clinical awareness and in providing data for policymakers.
Based on the available literature and published recommendations from international societies, the Working Party on Hemostasis (Swiss Society of Hematology) has prepared recommendations for pharmacological thromboprophylaxis in COVID-19 patients in the acute setting.
SMW is an international peer-reviewed medical journal, established in 1871.
Public Service Open Access is also known als Diamond or Platinum OA.
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