Is antibody-dependent enhancement playing a role in COVID-19 pathogenesis?

The pathogenesis of COVID-19 is currently believed to proceed via both directly cytotoxic and immune-mediated mechanisms. An additional mechanism facilitating viral cell entry and subsequent damage may involve the so-called antibody-dependent enhancement (ADE).

HLA studies in the context of coronavirus outbreaks

Little is known at the moment about specific immune mechanisms that would work against SARS-CoV-2, although such knowledge is expected to play a vital role. In this context, a particular focus has to be given to the human leucocyte antigen system that governs our adaptive immunity.

Response of a European surgical department to the COVID-19 crisis

At first sight, surgery appears to be only peripherally affected by the COVID.19 pandemic. However, the surgical department plays a key role in the response to this crisis. This article aims to provide a blueprint for a general surgery department’s response to this current pandemic crisis and also future events of similar magnitude.

COVID-19 and Iran: swimming with hands tied!

Like many other countries around the world, Iran is contending with the COVID-19 epidemic, but with the additional burden of international sanctions on supplies of medicines and medical equipment.

A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations

This article reviews the associations that have been best documented between markers at classical HLA genes and six of the most prevalent infectious diseases, and discusses this in a population genetics and evolutionary perspective.

Nationwide introduction of a new competency framework for undergraduate medical curricula: a collaborative approach

In 2018, Switzerland introduced a completely revised version of its national out­comes reference framework for the undergraduate medical curriculum. This paper describes the process put in place at a national level for its implementation.

Individualised nutritional support in medical inpatients – a practical guideline

Recent trials have demonstrated that early, individualised nutritional support improves clinical outcomes of patients. Hence, we must now think of clinical nutrition as a medical treatment that has a measurable impact on disease development and recovery.

Uranium exposure of the Swiss population based on 24-hour urinary excretion

Important regional differences in uranium exposure exist because of varying uranium concentrations in soil, water and food. Comprehensive data on the exposure of the general population to uranium is, however, scarce.

Characteristics and opinions of MD-PhD students and graduates from different European countries: a study from the European MD-PhD Association

MD-PhD programmes throughout the world provide a platform for medical trainees to commit to a physician-scientist career, qualifying with both a medical degree (MD, or equivalent) and Doctor of Philosophy (PhD).

Benign COVID-19 in an immunocompromised cancer patient -  the case of a married couple

The findings presented here suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.

Coronary and structural heart interventions in Switzerland 2018

Since 1987, based on a standardised questionnaire that has evolved over the years, all Swiss cardiology centres are asked to report yearly aggregate data on the number and type of percutaneous cardiac procedures performed.

Prevalence and practice of opioid prescription at a Swiss emergency department: 2013–2017

Information about the prevalence and characteristics of patients who are taking or receiving opioids and consult an emergency department (ED) may be useful in increasing clinical awareness and in providing data for policymakers.

Thromboprophylaxis and laboratory monitoring for in-hospital patients with COVID-19 - a Swiss consensus statement by the Working Party Hemostasis

Based on the available literature and published recommendations from international societies, the Working Party on Hemostasis (Swiss Society of Hematology) has prepared recommendations for pharmacological thromboprophylaxis in COVID-19 patients in the acute setting.