Identifying cancer driver genes from functional genomics screens

Cancer cells are dependent on a few driver genes for the constitutive activation of the signalling pathways which aid cellular proliferation. Targeting oncogenic-dependent genes has met with success, as demonstrated in several cancer types.

Should systemic sclerosis be recognised as an occupational disease in Switzerland?

Although the aetiology of systemic sclerosis is not yet completely understood, epidemiological studies have identified several occupational factors, such as exposure to silica, solvents or vibration, that contribute to its development.

Temporal work stressors and satisfaction with work, life and health among health professionals in Switzerland

Working in a hospital can be both rewarding and stressful. Whether one or the other is dominant depends on a number of factors ranging from shift work, physical demands, responsibilities and time pressure to job autonomy, work climate and leisure time.

A large-scale assessment of the healthcare burden of adhesive capsulitis of the shoulder joint

Frozen shoulder is a poorly understood pathological entity which is characterised by a painful and stiff shoulder. No current epidemiological data with respect to frozen shoulder-induced direct and indirect costs to the Swiss national healthcare system are available.

Plaque vulnerability in patients with high- and moderate-grade carotid stenosis – comparison of plaque features on MRI with histopathological findings

Plaque vulnerability plays an important role in determining the risk of subsequent cerebrovascular events in patients with carotid stenosis. Plaque morphology magnetic resonance imaging (MRI) can be used to assess plaque vulnerability.