The role of autophagy in HER2-targeted therapy

The HER2 oncogene is overexpressed in different tumour types and drugs specifically targeting it have been successfully used in cancer therapy. Resistance to these drugs ultimately occurs. In this context autophagy was reported to be upregulated.

The last decade of symptom-oriented research in emergency medicine: triage, work-up, and disposition

Symptom-oriented research has become the domain of emergency medicine research, as most other specialities have strongly focused diagnostic and prognostic research on individual disease entities.

Biomarkers in cardiovascular medicine: towards precision medicine

Rapid point-of-care HCV RNA quantification in capillary whole blood for diagnosing chronic HCV infection, monitoring treatment and detecting reinfection

Reliable rapid hepatitis C virus (HCV) antibody tests are available, but there is need for optimising viraemia detection. Rapid point-of-care capillary HCV RNA quantification could remove barriers to chronic hepatitis C diagnosis and treatment.

Appropriateness of antimicrobial prescribing in a Swiss tertiary care hospital: a repeated point prevalence survey

Inappropriate use of antimicrobials is associated with the emergence of antimicrobial resistance and adverse events. Antimicrobial stewardship programmes may both optimise treatment of infections and reduce antimicrobial resistance.

Clinical practice guidelines of medical societies in Switzerland: analysis of the current state

In Switzerland, Clinical practice guidelines (CPGs) are not generally registered by a single central institution. Therefore, the total number and overall quality of the existing guidelines are not known.