The Wnt pathway is not only involved in tumourigenesis and cell proliferation, but also contributes to chemoresistance and cancer stem cell propagation, responsible for tumour recurrence after therapy, metastasis and poor patient survival.
In recent years, there has been a revival in research on hallucinogenic drugs. One of the most interesting questions is how the typical effects of LSD are represented on a neuronal level. This question was recently addressed by three clinical trials.
Pneumocystis jirovecii pneumonia (PJP) may present with a very variable pattern of clinical and radiological manifestations, depending on the immunological status of the patient.
Controlled drinking as a therapy goal for problematic alcohol use is still a matter for debate, especially with regard to dependent drinkers. Furthermore, few structured controlled drinking programmes have been evaluated.
Since drug prescribing plays a major role in nursing home settings, its optimisation has become a public-health issue worldwide. To date, comprehensive data on drug utilisation in Swiss nursing homes are lacking.
Intermediate care units are important in many institutions where ICUs were overbooked and occupied by some patients not requiring ICU care. Limitations are the lack of surgeons trained in critical care and demands on the time of surgical staff.
SMW is an international peer-reviewed medical journal, established in 1871.
Public Service Open Access is also known als Diamond or Platinum OA.
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