New insights into the pathophysiology of inflammatory bowel disease: microbiota, epigenetics and common signalling pathways

The exact pathophysiology of inflammatory bowel disease is still unknown. However, over the years important insights allowed the development of novel therapeutic approaches that are at the threshold of introduction into clinical practice, or at least in clinical trials.

How I manage patients with anticoagulation-associated bleeding or urgent surgery

Management of anticoagulation-associated bleeding has become more challenging as the number of available drugs increases: vitamin K antagonists, unfractionated and low molecular heparin, as well as the newer direct oral anticoagulants targeting either factor Xa or thrombin.

Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): a re-evaluation of the threshold for delirium

Several instruments have been developed to screen for and detect delirium, including the Intensive Care Delirium Screening Checklist (ICDSC). However, the optimal cut-off score indicating delirium is debated.

Technical comment on: Hagner M. Open Access, data capitalism and academic publishing

Response to Matthias Egger and Angelika Kalt