Diagnosing diabetes and prediabetes seems to be trivial but is often delayed

Screening for liver cancer in high risk patients in Switzerland: Yes, it works, but No, we do not do it systematically!

Gains and losses on the road to understanding Alzheimer’s disease

What is finally responsible for neurodegeneration in human patients with Alzheimer’s disease? We need continuing research into all possible causes of Alzheimer’s disease to find a cure for this disease.

Mesenchymal stem cells: myths and reality

The number of studies addressing mesenchymal stem cell (MSC) biology and their capacity to treat a broad range of human diseases at the preclinical and clinical level has grown exponentially in the last two decades, with often confusing and conflicting results.

Antimicrobial stewardship in the intensive care setting – a review and critical appraisal of the literature

Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. This review summarises and assesses the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting.

Targeting the RAS pathway by mitogen-activated protein kinase inhibitors

Targeting of oncogenic driver mutations with small-molecule inhibitors resulted in powerful treatment options for cancer patients in recent years.

IL-6/STAT3/ARF: the guardians of senescence, cancer progression and metastasis in prostate cancer

This review summarises the current knowledge on the role of crucial pathways driving prostate cancer progression as well as metastatic disease and discusses the potential use of novel specific target molecules and how it can be exploited to avoid overtreatment and increase quality of life.

Focused use of drug screening in overdose patients increases impact on management

Referral rates in Swiss primary care with a special emphasis on reasons for encounter

Subjective perceptions as prognostic factors of time to fitness for work during a 4-year period after inpatient rehabilitation for orthopaedic trauma

Early safety outcome following transcatheter aortic valve implantation: is the amount of contrast media used a matter of concern?

Post-transplant outcome-clusters of psychological distress and health-related quality of life in lung transplant recipients

Surgical outcome after isolated on-pump and off-pump anterior descending coronary revascularisation

Cure of tuberculosis despite serum concentrations of antituberculosis drugs below published reference ranges

Low antituberculosis serum drug levels have been associated with poor tuberculosis treatment outcome, therefore therapeutic drug monitoring could be an important tool to guide tuberculosis treatment in case of treatment failure or late treatment response.

Cognitive improvement in patients with carotid stenosis is independent of treatment type

Death certificate notifications in the Swiss Childhood Cancer Registry: assessing completeness and registration procedures

Interdisciplinary options for diagnosis and treatment of organic erectile dysfunction

“The obesity paradox” in disease – is the protective effect of obesity true?

Obesity may, counterintuitively, be protective and associated with greater survival in certain groups of people, such as the very elderly or those with certain chronic diseases – the “obesity paradox”.

Role of the odorant receptor in neuronal connectivity in the olfactory bulb

A unique feature of the olfactory system is the dual role of the odorant receptor: it does detect odours in the olfactory epithelium but it also contributes to neuronal circuit formation in the olfactory bulb.

In vivo imaging of cardiac development and function in zebrafish using light sheet microscopy

Medical-ethical guidelines: Coercive measures in medicine