A biosimilar is a biological medicine highly similar to another, already approved medicine. Physicians should be aware of definition, approval process, and biochemical and clinical features that distinguish biosimilars from the reference product.
Immunosuppressive therapy must be guided by therapeutic drug monitoring (TDM) in paediatric liver (LT) and kidney transplantation (KT) patients to prevent under- and overdosing, which have clinical consequences.
Erectile dysfunction (ED) has recently been identified as a predictor of generalised vascular disease and, besides the functional sexual impairment, symptoms of ED may be indicative of underlying risk factors or cardiovascular comorbidities.
If drug therapy for secondary hyperparathyroidism (sHPTH) fails, total parathyroidectomy with autotransplantation of parathyroid tissue into the forearm (PTX-AT) is the most widely used procedure, but high recurrence rates are reported.
Recurrent glioblastoma (GBM) is a disease with poor prognosis for which there is no established standard therapy. A recent survey among Swiss neuro-oncology centres has shown considerable differences in treatment recommendations.
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