TY - JOUR AU - Bao, YS AU - Xie, RJ AU - Feng, SZ AU - Han, MZ PY - 2011/07/18 Y2 - 2024/03/28 TI - An evaluation of the RIFLE criteria for acute kidney injury after myeloablative allogeneic haematopoietic stem cell transplantation JF - Swiss Medical Weekly JA - Swiss Med Wkly VL - 141 IS - 2930 SE - Original article DO - 10.4414/smw.2011.13225 UR - https://smw.ch/index.php/smw/article/view/1330 SP - w13225 AB - <p><p>BACKGROUND: Patients undergoing myeloablative allogeneic haematopoietic stem cell transplantation (HSCT) have a higher incidence of acute kidney injury (AKI). RIFLE is a newly developed classification for AKI that includes three grades of severity – AKI-R, AKI-I, AKI-F.</p> <p>OBJECTIVE: The purpose of this study was to analyse retrospectively major risk factors for AKI at the time of myeloablative allo-HSCT and to use the RIFLE criteria to predict mortality in myeloablative allo-HSCT.</p> <p>METHODS: Renal function was evaluated in 143 patients with allo-HSCT by RIFLE criteria in order to assess the incidence, risk factors and mortality rate of various degrees of AKI.</p> <p>RESULTS: The results of this study showed that patients with hepatic veno-occlusive disease (HVOD) have a higher incidence of AKI-F than those without HVOD (P = 0.002). The incidence of AKI-I and AKI-F in patients with grade III-IV acute graft-versus-host disease (aGVHD) and increased total bilirubin was significantly higher than in those without (P = 0.001, P &lt;0.001). HVOD was an independent risk factor of AKI-F (OR 5.058, 95% CI 1.317–19.424, P = 0.018), and increased total bilirubin was an independent risk factor for AKI-F (OR 5.126, 95% CI 1.403–18.998, P = 0.014). Worsening RIFLE category was associated with increased mortality of the patients in the 100 days post-transplant (P = 0.003). In addition, 180-day survival of patients in different AKI classes was significantly different (P = 0.0095).</p> <p>CONCLUSION: AKI is common in patients with myeloablative allo-HSCT and is associated with increased risk of death. The RIFLE criteria appear to be an important tool for stratification of these patients on the basis of death risk.</p></p> ER -