@article{Winter_Hovaguimian_Kouyos_Schmidt_Bernasconi_Braun_Calmy_Notter_Stoeckle_Surial_Christinet_Cavassini_Depmeier_Läuchli_Boffi El Amari_Reinacher_Rasi_Bruggmann_Haerry_Bize_Low_Lehner_Quednow_Fehr_Hampel_2022, title={Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study}, volume={152}, url={https://smw.ch/index.php/smw/article/view/3223}, DOI={10.4414/SMW.2022.w30192}, abstractNote={<p><p>BACKGROUND: Changes in mental and sexual health among men having sex with men (MSM) due to the SARS-CoV-2 pandemic remain unclear.</p> <p>METHODS: Design: Longitudinal analysis of an ongoing, multicentre, pre-exposure prophylaxis (PrEP) cohort (NCT03893188) in Switzerland. Participants: HIV-negative MSM aged ≥18 who completed at least one questionnaire before and one after the start of the SARS-CoV-2 pandemic. Outcomes: Primary: mental health, defined as anxiety and depression scores assessed by the Patient Health Questionnaire-4. Secondary: sexual behaviour, well-being, PrEP use and disruption of care. Outcomes were assessed over seven periods corresponding to different SARS-CoV-2 prevention measures in Switzerland. We performed pairwise comparisons between periods (Wilcoxon signed rank test).</p> <p>RESULTS: Data from 1,043 participants were included. Whilst anxiety scores remained stable over time, depression scores worsened in the second wave and the second lockdown period compared to pre-pandemic scores. This was confirmed by pairwise comparisons (pre-SARS-CoV-2/second wave and pre-SARS-CoV-2/second lockdown: p <0.001). Downward trends in sexual activity,sexualized substance use, and a switch from daily to "event-driven" PrEP were found. Disruption of care affected 42.6% (790/1856) of daily PrEP users’ follow-up visits.</p> <p>CONCLUSION: In this longitudinal analysis of a PrEP cohort enrolling MSM, depression scores worsened in the second wave and the second lockdown compared to the pre-pandemic period.</p></p>}, number={2526}, journal={Swiss Medical Weekly}, author={Winter, Babette L. and Hovaguimian, Frédérique and Kouyos, Roger D. and Schmidt, Axel Jeremias and Bernasconi, Enos and Braun, Dominique L. and Calmy, Alexandra and Notter, Julia and Stoeckle, Marcel and Surial, Bernard and Christinet, Vanessa and Cavassini, Matthias and Depmeier, Carsten and Läuchli, Severin and Boffi El Amari, Emmanuelle and Reinacher, Matthias and Rasi, Manuela and Bruggmann, Philip and Haerry, David and Bize, Raphaël and Low, Nicola and Lehner, Andreas and Quednow, Boris B. and Fehr, Jan S. and Hampel, Benjamin}, year={2022}, month={Jun.}, pages={w30192} }