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Original article

Vol. 154 No. 2 (2024)

Successful treatment of immune checkpoint inhibitor-related periaortitis

  • Elias D. Bührer
  • Ian L. Alberts
  • Lisa Christ
  • Berna C. Özdemir
Cite this as:
Swiss Med Wkly. 2024;154:3631


We report a 64-year-old patient with melanoma receiving ipilimumab and nivolumab therapy who presented with a periaortic soft tissue mass around the abdominal aorta on restaging fluorodeoxyglucose positron emission tomography/computed tomography imaging. Clinical, laboratory, and radiologic findings resulted in a diagnosis of immune checkpoint inhibitor-related periaortitis. Periaortitis is a rare disease presenting with fibro-inflammatory tissue around the aorta and may lead to serious complications. Immune checkpoint inhibitors were discontinued, and the patient was treated with glucocorticoids, leading to a complete resolution of the periaortitis. To our knowledge, this is only the third reported case of immune checkpoint inhibitor-related periaortitis.


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