Skip to main navigation menu Skip to main content Skip to site footer

Original article

Vol. 153 No. 4 (2023)

Management of giant-cell arteritis in Switzerland: an online national survey

  • Michele Iudici
  • Andrea Katharina Hemmig
  • Mihaela Stegert
  • Delphine Sophie Courvoisier
  • Sabine Adler
  • Mike Oliver Becker
  • Christoph T. Berger
  • Diana Dan
  • Axel Finckh
  • Alfred Mahr
  • Thomas Neumann
  • Stephan Reichenbach
  • Camillo Ribi
  • Luca Seitz
  • Peter Villiger
  • Lukas Wildi
  • Thomas Daikeler
  • on behalf of Giant Cell Arteritis SCQM Study Group
DOI
https://doi.org/10.57187/smw.2023.40051
Cite this as:
Swiss Med Wkly. 2023;153:40051
Published
03.04.2023

Summary

AIMS OF THE STUDY: To assess current practices in diagnosing, treating, and following-up giant-cell arteritis by specialists in Switzerland and to identify the main barriers to using diagnostic tools.

METHODS: We performed a national survey of specialists potentially caring for patients with giant-cell arteritis. The survey was sent by email to all members of the Swiss Societies of Rheumatology and for Allergy and Immunology. A reminder was sent to nonresponders after 4 and 12 weeks. Its questions covered the following dimensions: respondents’ main characteristics, diagnosis, treatment, and imaging’s role during follow-up. The main study results were summarized using descriptive statistics.

RESULTS: Ninety-one specialists, primarily aged 46–65 years (n = 53/89; 59%), working in academic or nonacademic hospitals or private practice, and treating a median of 7.5 (interquartile range [IQR]: 3–12) patients with giant-cell arteritis per year participated in this survey. Ultrasound of temporal arteries/large vessels (n = 75/90; 83%) and positron-emission-tomography-computed tomography (n = 52/91; 57%) or magnetic resonance imaging (n = 46/90; 51%) of the aorta/extracranial arteries were the most common techniques used to diagnose giant-cell arteritis with cranial or large vessel involvement, respectively. Most participants reported a short time to obtain imaging tests or arterial biopsy. The glucocorticoid tapering scheme, glucocorticoid-sparing agent, and glucocorticoid-sparing treatment duration varied among the participants. Most physicians did not follow a predefined repeat imaging scheme for follow-up and mainly relied on structural changes (vascular thickening, stenosis, or dilatation) to drive treatment choice.

CONCLUSIONS: This survey indicates that imaging and temporal biopsy are rapidly accessible for diagnosing giant-cell arteritis in Switzerland but highlights heterogeneous practice in many disease management areas.

References

  1. Dejaco C , Brouwer E , Mason JC , Buttgereit F , Matteson EL , Dasgupta B . Giant cell arteritis and polymyalgia rheumatica: current challenges and opportunities. Nat Rev Rheumatol. 2017 Oct;13(10):578–92. https://doi.org/10.1038/nrrheum.2017.142 DOI: https://doi.org/10.1038/nrrheum.2017.142
  2. Hellmich B , Agueda A , Monti S , Buttgereit F , de Boysson H , Brouwer E , et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis. 2020 Jan;79(1):19–30. https://doi.org/10.1136/annrheumdis-2019-215672 DOI: https://doi.org/10.1136/annrheumdis-2019-215672
  3. Dejaco C , Ramiro S , Duftner C , Besson FL , Bley TA , Blockmans D , et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice. Ann Rheum Dis. 2018 May;77(5):636–43. https://doi.org/10.1136/annrheumdis-2017-212649 DOI: https://doi.org/10.1136/annrheumdis-2017-212649
  4. Camellino D , Matteson EL , Buttgereit F , Dejaco C . Monitoring and long-term management of giant cell arteritis and polymyalgia rheumatica. Nat Rev Rheumatol. 2020 Sep;16(9):481–95. https://doi.org/10.1038/s41584-020-0458-5 DOI: https://doi.org/10.1038/s41584-020-0458-5
  5. Koster MJ , Matteson EL , Warrington KJ . Large-vessel giant cell arteritis: diagnosis, monitoring and management. Rheumatology (Oxford). 2018 Feb;57 suppl_2:ii32–42. https://doi.org/10.1093/rheumatology/kex424 DOI: https://doi.org/10.1093/rheumatology/kex424
  6. Mahr AD , Jover JA , Spiera RF , Hernández-García C , Fernández-Gutiérrez B , Lavalley MP , et al. Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis. Arthritis Rheum. 2007 Aug;56(8):2789–97. https://doi.org/10.1002/art.22754 DOI: https://doi.org/10.1002/art.22754
  7. Stone JH , Tuckwell K , Dimonaco S , Klearman M , Aringer M , Blockmans D , et al. Trial of Tocilizumab in Giant-Cell Arteritis. N Engl J Med. 2017 Jul;377(4):317–28. https://doi.org/10.1056/NEJMoa1613849 DOI: https://doi.org/10.1056/NEJMoa1613849
  8. Villiger PM , Adler S , Kuchen S , Wermelinger F , Dan D , Fiege V , et al. Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. 2016 May;387(10031):1921–7. https://doi.org/10.1016/S0140-6736(16)00560-2 DOI: https://doi.org/10.1016/S0140-6736(16)00560-2
  9. Venhoff N , Schmidt WA , Lamprecht P , Tony HP , App C , Sieder C , et al. Efficacy and safety of secukinumab in patients with giant cell arteritis: study protocol for a randomized, parallel group, double-blind, placebo-controlled phase II trial. Trials. 2021 Aug;22(1):543. https://doi.org/10.1186/s13063-021-05520-1 DOI: https://doi.org/10.1186/s13063-021-05520-1
  10. Harkins P , Conway R . Giant cell arteritis: what is new in the preclinical and early clinical development pipeline? Expert Opin Investig Drugs. 2021;1–12. DOI: https://doi.org/10.1080/13543784.2021.1940949
  11. Harris PA , Taylor R , Thielke R , Payne J , Gonzalez N , Conde JG . Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009 Apr;42(2):377–81. https://doi.org/10.1016/j.jbi.2008.08.010 DOI: https://doi.org/10.1016/j.jbi.2008.08.010
  12. Harris PA , Taylor R , Minor BL , Elliott V , Fernandez M , O’Neal L , et al.; REDCap Consortium . The REDCap consortium: building an international community of software platform partners. J Biomed Inform. 2019 Jul;95:103208. https://doi.org/10.1016/j.jbi.2019.103208 DOI: https://doi.org/10.1016/j.jbi.2019.103208
  13. Eysenbach G . Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). J Med Internet Res. 2004 Sep;6(3):e34. https://doi.org/10.2196/jmir.6.3.e34 DOI: https://doi.org/10.2196/jmir.6.3.e34
  14. Mahr A , Hachulla E , de Boysson H , Guerroui N , Héron E , Vinzio S , et al. Presentation and Real-World Management of Giant Cell Arteritis (Artemis Study). Front Med (Lausanne). 2021 Nov;8:732934. https://doi.org/10.3389/fmed.2021.732934 DOI: https://doi.org/10.3389/fmed.2021.732934
  15. de Boysson H , Liozon E , Ly KH , Dumont A , Delmas C , Aouba A . The different clinical patterns of giant cell arteritis. Clin Exp Rheumatol. 2019;37 Suppl 117(2):57-60.
  16. González-Gay MA , Ortego-Centeno N , Ercole L . Clinical practice in giant cell arteritis based on a survey of specialists. Rev Clin Esp (Barc). 2022 May;222(5):266–71. https://doi.org/10.1016/j.rceng.2021.02.002 DOI: https://doi.org/10.1016/j.rceng.2021.02.002
  17. de Miguel EM , Macchioni P , Conticini E , Campochiaro C , Karalilova R , Monti S , et al. OP0184 Prevalence of subclinical giant cell arteritis in patients with Polymyalgia rheumatica. Ann Rheum Dis. 2022;81 Suppl 1:122–3. https://doi.org/10.1136/annrheumdis-2022-eular.1696 DOI: https://doi.org/10.1136/annrheumdis-2022-eular.1696
  18. Duftner C , Dejaco C , Sepriano A , Falzon L , Schmidt WA , Ramiro S . Imaging in diagnosis, outcome prediction and monitoring of large vessel vasculitis: a systematic literature review and meta-analysis informing the EULAR recommendations. RMD Open. 2018 Feb;4(1):e000612. https://doi.org/10.1136/rmdopen-2017-000612 DOI: https://doi.org/10.1136/rmdopen-2017-000612
  19. Berger CT , Sommer G , Aschwanden M , Staub D , Rottenburger C , Daikeler T . The clinical benefit of imaging in the diagnosis and treatment of giant cell arteritis. Swiss Med Wkly. 2018 Aug;148:w14661. https://doi.org/10.4414/smw.2018.14661 DOI: https://doi.org/10.4414/smw.2018.14661

Most read articles by the same author(s)

1 2 3 > >>