Prevalence, modes of administration and motives for cannabidiol use in young Swiss men
AIMS OF THE STUDY: In Switzerland, there has been a boom in the market for cannabidiol (CBD) products in recent years. However, little is known on the prevalence, modes of administration and motives for use of CBD products. The aim of the present study was to fill this gap using recent (2019) data from the Cohort Study on Substance Use Risk Factors (C-SURF).
METHODS: Between April and December 2019, an unselected sample of 5233 Swiss young men from the French- and German-speaking regions (mean age 28.2 years, standard deviation 1.3) completed a self-report questionnaire covering measures of use of CBD products, modes of administration and motives to use of CBD, tetrahydrocannabinol (THC) and cigarettes. Descriptive statistics were used to estimate prevalence of self-reported use, modes of administration and motives to use CBD, whereas logistic regression models were used to test the associations of linguistic region, THC and tobacco use with use of CBD.
RESULTS: Lifetime and 12-month prevalence of self-reported use of CBD were 32.4% and 18.5%, respectively. Among past 12-month CBD users, 79.4% used CBD once a month or less often, whereas 20.6% used it more than once a month. The most often reported modes of administration of CBD were in association with tobacco: flowers mixed with tobacco (67.5%), and CBD cigarettes with tobacco (37.1%), while 18.6% used flowers without tobacco. The three most reported reasons for using CBD were: out of curiosity (74.0%), to feel the effects of THC (38.1%) and for well-being and health (37.5%). In multivariable models, CBD use was associated with use of THC (odds ratio [OR] 9.85, 95% confidence interval [CI] 8.28–11.73), cigarettes (OR 2.74, 95% CI 2.28–3.29) or e-cigarettes (OR 1.5795% CI 1.27–1.95), as well as for the linguistic region (French-speaking vs German-speaking region OR 1.3895% CI 1.15–1.65).
CONCLUSIONS: Self-reported use of CBD is common among young Swiss men: about one third used CBD in their life and about one in five in the previous 12 months. However, the vast majority of CBD users used it infrequently and out of curiosity. CBD use was particularly prevalent among users of THC and cigarette smokers. CBD was most often used in combination with tobacco, thus exposing users to risks associated with smoking tobacco products.
- VanDolah HJ, Bauer BA, Mauck KF. Clinicians’ Guide to Cannabidiol and Hemp Oils. Mayo Clin Proc. 2019 Sep;94(9):1840–51. https://doi.org/10.1016/j.mayocp.2019.01.003
- Andre CM, Hausman JF, Guerriero G. Cannabis sativa: The Plant of the Thousand and One Molecules. Front Plant Sci. 2016 Feb;7:19. https://doi.org/10.3389/fpls.2016.00019
- Freeman TP, Craft S, Wilson J, Stylianou S, ElSohly M, Di Forti M, et al. Changes in delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations in cannabis over time: systematic review and meta-analysis. Addiction. 2021 May;116(5):1000–10. https://doi.org/10.1111/add.15253
- Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, et al. Cannabidiol: state of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017 Jul;175:133–50. https://doi.org/10.1016/j.pharmthera.2017.02.041
- White CM. A Review of Human Studies Assessing Cannabidiol’s (CBD) Therapeutic Actions and Potential. J Clin Pharmacol. 2019 Jul;59(7):923–34. https://doi.org/10.1002/jcph.1387
- Larsen C, Shahinas J. Dosage, Efficacy and Safety of Cannabidiol Administration in Adults: A Systematic Review of Human Trials. J Clin Med Res. 2020 Mar;12(3):129–41. https://doi.org/10.14740/jocmr4090
- Sholler DJ, Schoene L, Spindle TR. Therapeutic efficacy of cannabidiol (CBD): a review of evidence from clinical trials and human laboratory studies. Curr Addict Rep. 2020 Sep;7(3):405–12. https://doi.org/10.1007/s40429-020-00326-8
- Zobel F, Notari L, Schneider E, Rudmann O, et al. Cannabidiol (CBD): analyse de situation. 2018Lausanne: Addiction Suisse.
- Wheeler M, Merten JW, Gordon BT, Hamadi H. CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults. Subst Use Misuse. 2020;55(7):1138–45. https://doi.org/10.1080/10826084.2020.1729201
- Corroon J, Phillips JA. A Cross-Sectional Study of Cannabidiol Users. Cannabis Cannabinoid Res. 2018 Jul;3(1):152–61. https://doi.org/10.1089/can.2018.0006
- Berg CJ, Getachew B, Pulvers K, Sussman S, Wagener TL, Meyers C, et al. Vape shop owners’/managers’ attitudes about CBD, THC, and marijuana legal markets. Prev Med Rep. 2020 Sep;20:101208. https://doi.org/10.1016/j.pmedr.2020.101208
- Gmel G, Akre C, Astudillo M, Bähler C, Baggio S, Bertholet N, et al. The Swiss cohort study on substance use risk factors : findings of two waves. Sucht. 2015;61(4):251–62. https://doi.org/10.1024/0939-5911.a000380
- Gmel G, Kuendig H, Notari L, Gmel C. Monitorage suisse des addictions : consommation d’alcool, tabac et drogues illégales en Suisse en 2016. 2017, Addiction Suisse: Lausanne, Switzerland.
- Charitonidi E, Studer J, Gaume J, Gmel G, Daeppen JB, Bertholet N. Socioeconomic status and substance use among Swiss young men: a population-based cross-sectional study. BMC Public Health. 2016 Apr;16(1):333. https://doi.org/10.1186/s12889-016-2949-5
- Leigh NJ, Goniewicz ML. Effect of aerosolized nicotine on human bronchial epithelial cells is amplified after co-administration with cannabidiol (CBD): a pilot in vitro study. BMC Pharmacol Toxicol. 2020 Jun;21(1):42. https://doi.org/10.1186/s40360-020-00418-1
- Grafinger KE, Krönert S, Broillet A, Weinmann W. Cannabidiol and tetrahydrocannabinol concentrations in commercially available CBD E-liquids in Switzerland. Forensic Sci Int. 2020 May;310:110261. https://doi.org/10.1016/j.forsciint.2020.110261
- Freeman TP, Hindocha C, Green SF, Bloomfield MA. Medicinal use of cannabis based products and cannabinoids. BMJ. 2019 Apr;365:l1141. https://doi.org/10.1136/bmj.l1141
- Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, et al. Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA. 2015 Jun;313(24):2456–73. https://doi.org/10.1001/jama.2015.6358
- Chesney E, McGuire P, Freeman TP, Strang J, Englund A. Lack of evidence for the effectiveness or safety of over-the-counter cannabidiol products. Ther Adv Psychopharmacol. 2020 Sep;10:2045125320954992. https://doi.org/10.1177/2045125320954992
- Chesney E, Oliver D, Green A, Sovi S, Wilson J, Englund A, et al. Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology. 2020 Oct;45(11):1799–806. https://doi.org/10.1038/s41386-020-0667-2