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Review article: Biomedical intelligence

Vol. 151 No. 1112 (2021)

Role of myeloid-derived suppressor cells in hormone-dependent cancers

DOI
https://doi.org/10.4414/smw.2021.20483
Cite this as:
Swiss Med Wkly. 2021;151:w20483
Published
16.03.2021

Summary

Tumour-infiltrating myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells. The main feature of MDSCs is their ability to suppress T-cell activation and function, which leads to immunosuppressive activity in the tumour microenvironment. Higher numbers of circulating and tumour-infiltrating MDSCs have been observed in a large number of patients with various types of tumour, and are linked to poor prognosis, especially in hormone-driven tumours. Recently, it has been demonstrated that the recruitment of MDSCs in prostate cancer confers resistance to canonical endocrine therapies, opening a new approach to the treatment of hormone-driven cancer patients.

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