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Review article: Biomedical intelligence

Vol. 145 No. 3738 (2015)

The value of histopathological examination of salivary gland biopsies in diagnosis, prognosis and treatment of Sjögren’s Syndrome

  • Francesca Barone
  • Joana Campos
  • Simon Bowman
  • Benjamin A Fisher
DOI
https://doi.org/10.4414/smw.2015.14168
Cite this as:
Swiss Med Wkly. 2015;145:w14168
Published
06.09.2015

Summary

Primary Sjögren’s syndrome (pSS) is a complex autoimmune disease characterised by local exocrine glandular involvement and systemic multiorgan manifestations. In this review we will discuss the value of the histological examination of the salivary glands in the classification criteria, and more recently as prognostic tool for patient stratification and monitoring. The limitations of the current tools used to assess salivary gland pathology in pSS will also be reviewed in relation to using salivary gland biopsy analysis as an outcome measure in clinical trials.

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