Original article
Vol. 145 No. 2122 (2015)
Travelling activity and travel-related risks after allogeneic haematopoietic stem cell transplantation – a single centre survey
- Yvonne Hollenstein
- Luigia Elzi
- Christoph Hatz
- Jakob Passweg
- Maja Weisser
- Marcel Stoeckle
- Joerg Halter
- Adrian Egli
Summary
BACKGROUND: Travel activity and travel-related risks of patients after allogeneic haematopoietic stem cell transplantation (allo-HSCT) remain largely unknown. The aim of our study was to examine travel activity after allo-HSCT including travel behaviour and travel patterns.
METHODS: We analysed travel characteristics of allo-HSCT recipients by using a retrospective cross-sectional survey. Allo-HSCT patients were asked to complete a questionnaire during their annual health visits from 2010 to 2012.
RESULTS: Overall, 118/153 (77%) participating patients reported travel activity for a total of 201 travelling episodes. Travellers versus non-travellers were receiving immunosuppressive treatment in 35.6% versus 65.7% (p = 0.002), and had graft-versus-host-disease (GvHD) in 52.5% versus 62.9% (p = 0.17). In a multivariate analysis, the time between the transplantation and the survey was the only factor associated with travel activity (p <0.0001) and taking pretravel advice (p <0.0001). In 34.8% of travel episodes pretravel advice was sought. Patients with pretravel advice reported travel-related symptoms more frequently. Minor respiratory (27/201) and gastrointestinal (23/201) symptoms were most frequently indicated. Four percent (8/201) of the patients were hospitalised while travelling.
CONCLUSION: We conclude that travelling after allo-HSCT is frequent and linked to the time since transplantation. We could not define specific risks for any destination. Nevertheless, pretravel advice and preparation are highly recommended for immunosuppressed patients.
References
- Mikati T, Taur Y, Seo SK, Shah MK. International travel patterns and travel risks of patients diagnosed with cancer. J Travel Med. 2013;20(2):71–7. doi: 10.1111/jtm.12013. PubMed PMID: 23464712.
- Salit IE, Sano M, Boggild AK, Kain KC. Travel patterns and risk behaviour of HIV-positive people travelling internationally. CMAJ. 2005;172(7):884–8. doi: 10.1503/cmaj.1040877. PubMed PMID: 15795409; PubMed Central PMCID: PMC554873.
- Uslan DZ, Patel R, Virk A. International travel and exposure risks in solid-organ transplant recipients. Transplantation. 2008;86(3):407–12. doi: 10.1097/TP.0b013e31817c0673. PubMed PMID: 18698243.
- Wieten RW, Leenstra T, Goorhuis A, van Vugt M, Grobusch MP. Health risks of travelers with medical conditions – a retrospective analysis. J Travel Med. 2012;19(2):104–10. doi: 10.1111/j.1708–8305.2011.00594.x. PubMed PMID: 22414035.
- Skogmar S, Balcha TT, Jemal ZH, Bjork J, Deressa W, Schon T, et al. Development of a clinical scoring system for assessment of immunosuppression in patients with tuberculosis and HIV infection without access to CD4 cell testing – results from a cross-sectional study in Ethiopia. Glob Health Action. 2014;7:23105. doi: 10.3402/gha.v7.23105. PubMed PMID: 24560255; PubMed Central PMCID: PMC3925806.
- Sood S, Testro AG. Immune monitoring post liver transplant. World J Transplant. 2014;4(1):30–9. doi: 10.5500/wjt.v4.i1.30. PubMed PMID: 24669365; PubMed Central PMCID: PMC3964194.
- Passweg JR, Baldomero H, Gratwohl A, Bregni M, Cesaro S, Dreger P, et al. The EBMT activity survey: 1990–2010. Bone Marrow Transplant. 2012;47(7):906–23. doi: 10.1038/bmt.2012.66. PubMed PMID: 22543746.
- Danby R, Rocha V. Improving engraftment and immune reconstitution in umbilical cord blood transplantation. Front Immunol. 2014;5:68. doi: 10.3389/fimmu.2014.00068. PubMed PMID: 24605111; PubMed Central PMCID: PMC3932655.
- Komanduri KV, Wieder ED, Benjamin CL, Levy RB. The evolving art of hematopoietic stem cell transplantation: translational research in post-transplant immune reconstitution and immunosuppression. Immunol Res. 2013;57(1–3):140–50. doi: 10.1007/s12026–013–8461–4. PubMed PMID: 24242818.
- Dolnicar S, Lazarevski K, Yanamandram V. Quality-of-life and travel motivations: integrating the two concepts in the Grevillea Model. In: Uysal M, Perdue RR, Joseph M, editors. Handbook of Tourism and Quality-of-Life Research: Enhancing the Lives of Tourists and Residents of Host Communities. London: Springer; 2012. p. 293–308.
- Strauss-Blasche G, Reithofer B, Schobersberger W, Ekmekcioglu C, Marktl W. Effect of vacation on health: moderating factors of vacation outcome. J Travel Med. 2005;12(2):94–101. PubMed PMID: 15996454.
- Kotton CN, Freedman DO. Centers for Disease Control and Prevention – recommendation on Travelers’ health 2014. Available from: http://wwwnc.cdc.gov/travel/yellowbook/2014/table-of-contents.
- Linhares YP, Pavletic S, Gale RP. Chronic GVHD: Where are we? Where do we want to be? Will immunomodulatory drugs help? Bone Marrow Transplant. 2013;48(2):203–9. doi: 10.1038/bmt.2012.76. PubMed PMID: 22580766.
- Finke J. Chronic graft versus host disease (GvHD): causes, manifestation, diagnosis and treatment option. Dtsch Med Wochenschr. 2012;137(42):2166–70. doi: 10.1055/s-0032–1327212. PubMed PMID: 23055360.
- McCarthy AE, Mileno MD. Prevention and treatment of travel-related infections in compromised hosts. Curr Opin Infect Dis. 2006;19(5):450–5. doi: 10.1097/01.qco.0000244050.15888.6f. PubMed PMID: 16940868.
- Al-Eid MA, Tutschka PJ, Wagner HN, Jr., Santos GW, Tsan MF. Functional asplenia in patients with chronic graft-versus-host disease: concise communication. J Nucl Med. 1983;24(12):1123–6. PubMed PMID: 6358431.
- Newland A, Provan D, Myint S. Preventing severe infection after splenectomy. BMJ. 2005;331(7514):417–8. doi: 10.1136/bmj.331.7514.417. PubMed PMID: 16110056; PubMed Central PMCID: PMC1188098.
- Canton R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, et al. Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect. 2008;14(Suppl 1):144–53. doi: 10.1111/j.1469–0691.2007.01850.x. PubMed PMID: 18154538.
- Nordmann P. Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge. Med Mal Infect. 2014;44(2):51–6. doi: 10.1016/j.medmal.2013.11.007. PubMed PMID: 24360201.
- Boggild AK, Sano M, Humar A, Salit I, Gilman M, Kain KC. Travel patterns and risk behavior in solid organ transplant recipients. J Travel Med. 2004;11(1):37–43. PubMed PMID: 14769286.
- Walz A, Tschudi P, Badertscher N, Hatz C. Pre travel advice – a study among Swiss general practitioners. Ther Umsch. 2013;70(6):313–7. doi: 10.1024/0040–5930/a000409. PubMed PMID: 23732446. German.
- Machado CM. Reimmunization after hematopoietic stem cell transplantation. Expert Rev Vaccines. 2005;4(2):219–28. doi: 10.1586/14760584.4.2.219. PubMed PMID: 15889995.
- Mikati T, Griffin K, Lane D, Matasar M, Shah MK. International travel patterns and travel risks for stem cell transplant recipients. J Travel Med. 2015;22(1):39–47. doi: 10.1111/jtm.12166. PubMed PMID: 25327693.
- Kendrick MA. Study of illness among Americans returning from international travel, July 11–August 24, 1971. (preliminary data). J Infect Dis. 1972;126(6):684–5. PubMed PMID: 4677693.
- Steffen R, Rickenbach M, Wilhelm U, Helminger A, Schar M. Health problems after travel to developing countries. J Infect Dis. 1987;156(1):84–91. PubMed PMID: 3598228.
- Stienlauf S, Segal G, Sidi Y, Schwartz E. Epidemiology of travel-related hospitalization. J Travel Med. 2005;12(3):136–41. PubMed PMID: 15996442.
- Dahlgren AL, DeRoo L, Steffen R. Prevention of travel-related infectious diseases: knowledge, practices and attitudes of Swedish travellers. Scand J Infect Dis. 2006;38(11–12):1074–80. doi: 10.1080/00365540600868354. PubMed PMID: 17148080.
- Kuenzli E, Jaeger VK, Frei R, Neumayr A, DeCrom S, Haller S, et al. High colonization rates of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in Swiss Travellers to South Asia – a prospective observational multicentre cohort study looking at epidemiology, microbiology and risk factors. BMC Infect Dis. 2014;14(1):528. doi: 10.1186/1471–2334–14–528. PubMed PMID: 25270732.
- Lerchenfeldt SM, Cronin SM, Chandrasekar PH. Vaccination adherence in hematopoietic stem cell transplant patients: a pilot study on the impact of vaccination cards and reminder telephone calls. Transpl Infect Dis. 2013;15(6):634–8. doi: 10.1111/tid.12110. PubMed PMID: 23890163.
- Ariza-Heredia EJ, Gulbis AM, Stolar KR, Kebriaei P, Shah DP, McConn KK, et al. Vaccination guidelines after hematopoietic stem cell transplantation: practitioners’ knowledge, attitudes, and gap between guidelines and clinical practice. Transpl Infect Dis. 2014;16(6):878–86. doi: 10.1111/tid.12312. PubMed PMID: 25405922.
- Ljungman P, Cordonnier C, Einsele H, Englund J, Machado CM, Storek J, et al. Vaccination of hematopoietic cell transplant recipients. Bone Marrow Transplant. 2009;44(8):521–6. doi: 10.1038/bmt.2009.263. PubMed PMID: 19861986.
- Vaudaux B, Binz H, Gallacchi P, Landry P, Mühlemann K, Siegrist CA, et al. Empfehlungen zur Impfung von Empfängerinnen und Empfänger von Blut-Stammzellen. BAG Bulletin. 2012;21:363–9.
- Van Herck K, Van Damme P, Castelli F, Zuckerman J, Nothdurft H, Dahlgren AL, et al. Knowledge, attitudes and practices in travel-related infectious diseases: the European airport survey. J Travel Med. 2004;11(1):3–8. PubMed PMID: 14769280.
- Pavli A, Maltezou HC. Malaria and travellers visiting friends and relatives. Travel Med Infect Dis. 2010;8(3):161–8. doi: 10.1016/j.tmaid.2010.01.003. PubMed PMID: 20541136.