Skip to main navigation menu Skip to main content Skip to site footer

Review article: Biomedical intelligence

Vol. 144 No. 4950 (2014)

Nanotechnology in medicine: European research and its implications

  • Margarethe Hofmann-Amtenbrink
  • Heinrich Hofmann
  • Alessandra Hool
  • François Roubert
DOI
https://doi.org/10.4414/smw.2014.14044
Cite this as:
Swiss Med Wkly. 2014;144:w14044
Published
30.11.2014

Summary

In this study, we explore and discuss nanoparticles and nanoscale materials and their use in medicine (nanomedicine) and pharmaceutics (nanopharmaceutics). The study is aimed at shedding light on this highly multidisciplinary research field and at examining the influence of research funding, industrial applications, and legal and regulatory frameworks on the research in this field, a clear understanding of which is essential to efficiently support the translation of research findings into industrial and clinical applications and to enable access to a larger society.

References

  1. Granqvist, CG, Buhrmann, RA. Ultrafine metal particles. J Appl Phys. 1976;47(5):2200–19
  2. Marty JJ, Oppenheim RC, Speiser P. Nanoparticles – a new colloidal drug delivery system. Pharm Acta Helv. 1978;53(1):17–23. PubMed PMID: 643885.
  3. Kreuter J. Nanoparticles – a historical perspective. Int J Pharm. 2007;22:331(1):1–10. PubMed PMID: 17110063.
  4. Schroder U, Segren S, Gemmefors C, Hedlund G, Jansson B, Sjogren HO, et al. Magnetic carbohydrate nanoparticles for affinity cell separation. J Immunol Methods. 1986;93(1):45–53. PubMed PMID: 3772108.
  5. Schmid GD, Decker M, Ernst H, Fuchs H, Grünwald W, Grunwald A, et al. Small Dimensions and Material Properties – A Definition of Nanotechnology. Bad Neuenahr-Ahrweiler: Europäische Akademie zur Erforschung von Folgen wissenschaftlich-technischer Entwicklungen GmbH; 2003.
  6. Nanomedicine. Strasbourg: European Science Foundation, 2005.
  7. Somorjai, GA, Bing Zhou B, Nanotechnology in Catalysis 3, Springer Series: Nanostructure Science and Technology Volume package: Nanotechnology in Catalysis Zhou, B., Han, S., Raja, R., Somorjai, G.A. (Eds.) ISBN-10: 0–387–34687–2, Springer, page IX, 2007.
  8. Hu CM, Zhang L. Nanoparticle-based combination therapy toward overcoming drug resistance in cancer. Biochem Pharm. 2012;83(8):1104–11. PubMed PMID: 22285912.
  9. Javed A. Nanopharmaceutics. Int J Pharm Investig. 2011;1(2):61.
  10. Bawa RM, Melethil S, Simmons WJ; Harris D. Nanopharmaceuticals: Patenting Issues and FDA Regulatory Challenges. The SciTech Lawyer. 2008;5(2).
  11. Neuberger T, Schöpf B, Hofmann, H, Hofmann, M, von Rechenberg B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J Magn Magn Mater. 2005;293(1):483–96.
  12. He LM, Musick MD, Nicewarner SR, Salinas FG, Benkovic SJ, Natan MJ, et al. Colloidal Au-Enhanced Surface Plasmon Resonance for Ultrasensitive Detection of DNA Hybridization. J Am Chem Soc. 2000;122(38):9071–77.
  13. Cassette E, Helle M, Bezdetnaya L, Marchal F, Dubertret B, Pons T. Design of new quantum dot materials for deep tissue infrared imaging. Adv Drug Deliv Rev. 2013;65(5):719–31. PubMed PMID: 22981756.
  14. Etheridge ML, Campbell SA, Erdman AG, Haynes CL, Wolf SM, McCullough J. The big picture on nanomedicine: the state of investigational and approved nanomedicine products. Nanomedicine: nanotechnology, biology, and medicine. 2013;9(1):1–14. PubMed PMID: 22684017.
  15. Considering Whether an FDA-Regulated Product Involves the Application of Nanotechnology, Guidance for Industry 1, http://www.fda.gov/RegulatoryInformation/Guidances/ucm257698.htm (2014)
  16. Krug HF, Wick P. Nanotoxicology: An Interdisciplinary Challenge. Angew Chem Int Ed Engl. 2011 Jan 11. PubMed PMID: 21225978. Epub 2011/01/13. Eng.
  17. Bleeker EAJ, Cassee FR, Geertsma RE, de Jongen WH, Heugens EHW, Koers-Jacquemijns M, et al. Interpretation and implications of the European Commission Recommendation on the definition of nanomaterial. National RIVM Letter Report 60135800, Institute for Public Health and the Environment, 2012.
  18. Bawarski WE, Chidlowsky E, Bharali DJ, Mousa SA. Emerging nanopharmaceuticals. Nanomedicine: nanotechnology, biology, and medicine. 2008;4(4):273–82. PubMed PMID: 18640076.
  19. Gradishar WJ. Albumin-bound paclitaxel: a next-generation taxane. Expert opinion on pharmacotherapy. 2006;7(8):1041–53. PubMed PMID: 16722814.
  20. Liu Y, Niu T, Zhang L,Yang J. Review on nano-drugs. Sci Res. 2010;2(1):41–8.
  21. Gaspar R. Nanomedicines Challenges and Opportunities in a Global Development Environment. Policy Issues in Nanotechnology and Oncology – National Cancer Policy Forum Workshop, Institute of Medicine, July 12–13, 2010; Washington DC2010.
  22. Nanomedicine 2020 – Contribution of Nanomedicine to Horizon 2020. White Paper to the Horizon 2020 Framework Programme for Research and Innovation, 2013.