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Review article: Biomedical intelligence

Vol. 143 No. 2324 (2013)

Paediatric ventricular assist devices: current achievements

  • Martin Schweiger
  • Hitendu Dave
  • Olga Romanchenko
  • Frithjof Lemme
  • Michael Hübler
DOI
https://doi.org/10.4414/smw.2013.13804
Cite this as:
Swiss Med Wkly. 2013;143:w13804
Published
02.06.2013

Summary

In chronic cardiomyopathy, mechanical circulatory support plays an increasingly important role for children as the shortage of suitable donor hearts increases times on the transplant waiting list. Ventricular assist devices (VADs) for adults have evolved dramatically over the last decade, both as a bridge to transplantation and for permanent support. In contrast, VADs designed for children, especially for all age groups, are still in their infancy. The Medos HIA and the Berlin Heart Excor are specially designed for children with a body surface area <1.2 m2. Increased experience with existing paediatric VADs and the introduction of third-generation VADs for the paediatric age group offer new possibilities for children suffering from end-stage heart failure. We review the literature on this topic, summarise the indications and contraindications for long-term support VADs and describe the decision-making algorithm used at our institution for use of long-term VADs in children.

References

  1. Adachi I, C.D. Fraser, Jr., Mechanical circulatory support for infants and small children. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2011;14(1):38–44.
  2. Schweiger M, et al. Improving the rate of organ donation. Transplant Proc. 2004;36(9):2543–5.
  3. Almond CS, et al. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009;119(5):717–27.
  4. Schneider S, et al. Assessing the potential of international organ exchange – the Swiss experience. Eur J Cardiothorac Surg. 2011;40(6):1368–73.
  5. Krabatsch T, et al. Mechanical circulatory support-results, developments and trends. J Cardiovasc Transl Res. 2011;4(3):332–9.
  6. Krabatsch T, et al. Improvements in implantable mechanical circulatory support systems: literature overview and update. Herz. 2011;36(7):622–9.
  7. Reinhartz O, et al. Multicenter experience with the thoratec ventricular assist device in children and adolescents. J Heart Lung Transplant. 2001;20(4):439–48.
  8. Blume ED, et al. Outcomes of children bridged to heart transplantation with ventricular assist devices: a multi-institutional study. Circulation. 2006;113(19):2313–9.
  9. Fraser CD, Jr., et al. Prospective trial of a pediatric ventricular assist device. N Engl J Med. 2012;367(6):532–41.
  10. Jeewa A, et al. Outcomes with ventricular assist device versus extracorporeal membrane oxygenation as a bridge to pediatric heart transplantation. Artif Organs. 2010;34(12):1087–91.
  11. Morales DL, et al. Bridging children of all sizes to cardiac transplantation: the initial multicenter North American experience with the Berlin Heart EXCOR ventricular assist device. J Heart Lung Transplant. 2011;30(1):1–8.
  12. Kirklin JK, et al. The Fourth INTERMACS Annual Report: 4,000 implants and counting. J Heart Lung Transplant. 2012;31(2):117–26.
  13. DeBakey ME. Left ventricular bypass pump for cardiac assistance. Clinical experience. Am J Cardiol. 1971;27(1):3–11.
  14. Karl TR, Horton SB, Brizard C. Postoperative support with the centrifugal pump ventricular assist device (VAD). Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006: p. 83–91.
  15. Warnecke H, et al. Mechanical left ventricular support as a bridge to cardiac transplantation in childhood. Eur J Cardiothorac Surg. 1991;5(6):330–3.
  16. Hetzer R, et al. Mechanical cardiac support in the young with the Berlin Heart EXCOR pulsatile ventricular assist device: 15 years’ experience. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006: p. 99–108.
  17. Konertz W, et al. Clinical experience with the MEDOS HIA-VAD system in infants and children: a preliminary report. Ann Thorac Surg. 1997;63(4):1138–44.
  18. Owens WR, et al. Initial clinical experience with the HeartMate II ventricular assist system in a pediatric institution. Artif Organs. 2010;34(7):600–3.
  19. Fan Y, et al. Outcomes of ventricular assist device support in young patients with small body surface area. Eur J Cardiothorac Surg. 2011;39(5):699–704.
  20. Reinhartz O, et al. Thoratec ventricular assist devices in pediatric patients: update on clinical results. ASAIO J. 2005;51(5):501–3.
  21. Mikus E, et al. Reversibility of fixed pulmonary hypertension in left ventricular assist device support recipients. Eur J Cardiothorac Surg. 2011;40(4):971–7.
  22. Martin J, et al. Implantable left ventricular assist device for treatment of pulmonary hypertension in candidates for orthotopic heart transplantation-a preliminary study. Eur J Cardiothorac Surg. 2004;25(6):971–7.
  23. Potapov EV, et al. Bridging to transplantability with a ventricular assist device. J Thorac Cardiovasc Surg. 2005;130(3):930.
  24. Castells E, et al. Recovery of ventricular function with a left ventricular axial pump in a patient with end-stage toxic cardiomyopathy not a candidate for heart transplantation: first experience in Spain. Transplant Proc. 2009;41(6):2237–9.
  25. Freilich M, et al. Recovery from anthracycline cardiomyopathy after long-term support with a continuous flow left ventricular assist device. J Heart Lung Transplant. 2009;28(1):101–3.
  26. Khan N, et al. Remission of chronic anthracycline-induced heart failure with support from a continuous-flow left ventricular assist device. Tex Heart Inst J. 2012;39(4):554–6.
  27. Potapov EV, Stiller B, Hetzer R. Ventricular assist devices in children: current achievements and future perspectives. Pediatr Transplant. 2007;11(3):241–55.
  28. Kaczmarek I, et al. Mechanical circulatory support in infants and adults with the MEDOS/HIA assist device. Artif Organs. 2005;29(10):857–60.
  29. Stiller B, et al. Pneumatic pulsatile ventricular assist devices in children under 1 year of age. Eur J Cardiothorac Surg. 2005;28(2):234–9.
  30. Almond CS, et al. Berlin Heart EXCOR Pediatric ventricular assist device Investigational Device Exemption study: study design and rationale. Am Heart J. 2011;162(3):425–35 e6.
  31. Hill JD, Reinhartz O. Clinical outcomes in pediatric patients implanted with Thoratec ventricular assist device. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006: p. 115–22.
  32. Slaughter MS, et al. Home discharge experience with the Thoratec TLC-II portable driver. ASAIO J. 2007;53(2):132–5.
  33. Reinhartz O, Copeland JG, Farrar DJ. Thoratec ventricular assist devices in children with less than 1.3 m2 of body surface area. ASAIO J. 2003;49(6):727–30.
  34. Potapov EV, et al. Pulsatile flow in patients with a novel nonpulsatile implantable ventricular assist device. Circulation. 2000;102(19 Suppl 3): p. III183–7.
  35. Imamura M, et al. The first successful DeBakey VAD child implantation as a bridge to transplant. ASAIO J. 2005;51(5):670–2.
  36. Morales DL, et al. Lessons learned from the first application of the DeBakey VAD Child: an intracorporeal ventricular assist device for children. J Heart Lung Transplant. 2005;24(3):331–7.
  37. Fraser CD, Jr., et al. Preliminary experience with the MicroMed DeBakey pediatric ventricular assist device. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006: p. 109–14.
  38. Wieselthaler GM, et al. Initial clinical experience with a novel left ventricular assist device with a magnetically levitated rotor in a multi-institutional trial. J Heart Lung Transplant. 2010;29(11):1218–25.
  39. Krabatsch T, et al. Biventricular circulatory support with two miniaturized implantable assist devices. Circulation. 2011;124(11 Suppl):S179–86.
  40. Huebler M, et al. Mechanical circulatory support of systemic ventricle in adults with transposition of great arteries. ASAIO J. 2012;58(1):12–4.
  41. Miera O, et al. First experiences with the HeartWare ventricular assist system in children. Ann Thorac Surg. 2011;91(4):1256–60.
  42. D’Alessandro D, et al. First reported use of the heartware HVAD in the US as bridge to transplant in an adolescent. Pediatr Transplant. 2012.
  43. Copeland JG, et al. Cardiac replacement with a total artificial heart as a bridge to transplantation. N Engl J Med. 2004;351(9):859–67.
  44. Leprince P, et al. Patients with a body surface area less than 1.7 m2 have a good outcome with the CardioWest Total Artificial Heart. J Heart Lung Transplant. 2005;24(10):1501–5.
  45. Morreim EH, et al. Innovation in human research protection: the AbioCor artificial heart trial. Am J Bioeth. 2006;6(5):W6–16.
  46. Kirklin JK, et al. Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation? J Thorac Cardiovasc Surg. 2012;144(3):584–603; discussion 597–8.
  47. Rossano JW, et al. Effect of body mass index on outcome in pediatric heart transplant patients. J Heart Lung Transplant. 2007;26(7):718–23.
  48. Aurora P, et al. The Registry of the International Society for Heart and Lung Transplantation: thirteenth official pediatric lung and heart-lung transplantation report – 2010. J Heart Lung Transplant. 2010;29(10):1129–41.
  49. Alba AC, et al. The effect of ventricular assist devices on long-term post-transplant outcomes: a systematic review of observational studies. Eur J Heart Fail. 2011;13(7):785–95.
  50. Krabatsch T, et al. Is bridge to recovery more likely with pulsatile left ventricular assist devices than with nonpulsatile-flow systems? Ann Thorac Surg. 2011;91(5):1335–40.
  51. Bruggink AH, et al. Reverse remodeling of the myocardial extracellular matrix after prolonged left ventricular assist device support follows a biphasic pattern. J Heart Lung Transplant. 2006;25(9):1091–8.
  52. Mohapatra B, et al. Short-term mechanical unloading and reverse remodeling of failing hearts in children. J Heart Lung Transplant. 2010;29(1):98–104.
  53. Birks EJ, et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006;355(18):1873–84.
  54. Potapov EV, Schweiger M, Krabatsch T. Percutaneous balloon occlusion of a left ventricular assist device outflow cannula to facilitate evaluation of myocardial recovery. J Heart Lung Transplant. 2011;30(11):1300–1.
  55. Dandel M, et al. Prediction of cardiac stability after weaning from left ventricular assist devices in patients with idiopathic dilated cardiomyopathy. Circulation. 2008;118(14 Suppl):S94–105.
  56. Liang H, et al. Prediction of cardiac function after weaning from ventricular assist devices. J Thorac Cardiovasc Surg. 2005;130(6):1555–60.
  57. Dandel M, et al. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation. 2005;112(9 Suppl):I37–45.

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