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Review article: Biomedical intelligence

Vol. 142 No. 2728 (2012)

Modelling HIV infection and therapies in humanised mice

  • Marc Nischang
  • Gustavo Gers-Huber
  • Annette Audigé
  • Ramesh Akkina
  • Roberto F Speck
DOI
https://doi.org/10.4414/smw.2012.13618
Cite this as:
Swiss Med Wkly. 2012;142:w13618
Published
01.07.2012

Summary

The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.

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