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Review article: Biomedical intelligence

Vol. 142 No. 1516 (2012)

The emerging role of serotonin in liver regeneration

  • George K Papadimas
  • Konstantinos N Tzirogiannis
  • Michael G Mykoniatis
  • Agni D Grypioti
  • Georgia A Manta
  • Georgios I Panoutsopoulos
Cite this as:
Swiss Med Wkly. 2012;142:w13548


Serotonin has a multifunctional role in many different organs serving either as a neurotransmitter in the central nervous system or a paracrine factor in the gastrointestinal tract. Over 90% of serotonin is synthesised in the enterochromaffin cells of the intestine and subsequently taken up by platelets. The involvement of platelet-derived serotonin in liver mass restoration after partial hepatectomy or toxic injury has been greatly investigated during the last decade. There is a growing body of evidence implicating serotonin in hepatic regeneration through altered expression of serotonin receptor subtypes in the liver. This review article provides a brief overview on the current knowledge about the actions of serotonin in liver regeneration.


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