Skip to main navigation menu Skip to main content Skip to site footer

Short communication

Vol. 142 No. 1112 (2012)

Cardiac involvement in Churg-Strauss syndrome mimicking acute coronary syndrome

  • Fabio Rigamonti
  • Edoardo De Benedetti
  • Igor Letovanec
  • Antoine Rosset
  • Carlo Chizzolini
DOI
https://doi.org/10.57187/smw.2020.13543
Cite this as:
Swiss Med Wkly. 2012;142:w13543
Published
11.03.2012

Abstract

Churg-Strauss syndrome (CSS) is a rare multisystemic disorder of unknown origin and cardiac involvement is one of the most serious manifestations of the disease, accounting for approximately one-half of deaths attributable to CSS. Cardiac manifestation can be acute and mimic acute coronary syndrome (ACS). In this setting checking the blood leucocyte count can reveal hypereosinophilia and lead to a diagnosis of CSS.

References

  1. Masi AT, Hunder GG, Lie JT, et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) Arthritis Rheum. 1990;33:1094. DOI: https://doi.org/10.1002/art.1780330806
  2. Lanham JG, Elkon KB, Pusey CD, Hughes GR. Systemic vasculitis with asthma and eosinophilia: A clinical approach to the Churg-Strauss syndrome. Medicine. 1984;63:65. DOI: https://doi.org/10.1097/00005792-198403000-00001
  3. Noth I, Strek ME, LeV AR. Churg-Strauss syndrome. Lancet. 2003;361:587–94. DOI: https://doi.org/10.1016/S0140-6736(03)12518-4
  4. Della Rossa A, Baldini C, Tavoni A, et al. Churg-Strauss syndrome: clinical and serological features of 19 patients from a single Italian centre. Rheumatology. (Oxford) 2002;41:1286. DOI: https://doi.org/10.1093/rheumatology/41.11.1286
  5. Sable-Fourtassou R, Cohen P, Mahr A, et al. Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome. Ann Intern Med. 2005;143:632. DOI: https://doi.org/10.7326/0003-4819-143-9-200511010-00006
  6. Neumann T, Manger B, Schmid M, et al. Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis. Medicine. (Baltimore) 2009;88:236. DOI: https://doi.org/10.1097/MD.0b013e3181af35a5
  7. Corradi D, Maestri R, Facchetti F. Post-partum Churg-Strauss syndrome with severe cardiac involvement: description of a case and review of the literature. Clin Rheumatol. 2009;28:739. DOI: https://doi.org/10.1007/s10067-009-1143-x
  8. Ogbogu PU, Rosing DR, Horne MK, 3rd. Cardiovascular manifestations of hypereosinophilic syndromes. Immunol Allergy Clin North Am. 2007;27:457. DOI: https://doi.org/10.1016/j.iac.2007.07.001
  9. Weller PF, Bubley GJ. The idiopathic hypereosinophilic syndrome. Blood. 1994;83:2759. DOI: https://doi.org/10.1182/blood.V83.10.2759.2759
  10. Hirakawa Y, Koyanagi S, Matsumoto T, Takeshita A, Nakamura M. A case of variant angina associated with eosinophilia. Am J Med. 1989;87:472–4. DOI: https://doi.org/10.1016/S0002-9343(89)80837-X
  11. Hertzman PA, Maddoux GL, Stenberg EM, Heyes MP, Mefford IN, Kephart GM, et al. Repeated coronary artery spasm in a young woman with the eosinophilia-myalgia syndrome. JAMA. 1992;267:1932–34. DOI: https://doi.org/10.1001/jama.1992.03480210094039
  12. Naohiko Takahashi, Katsuhiro Kondo, Juntaro Aoyagi. Acute myocardial infarction associated with hypereosinophilic syndrome in a young man. Jpn Circ J. 1997;61:803–6. DOI: https://doi.org/10.1253/jcj.61.803
  13. Mavrogeni S, Manoussakis MN, Karagiorgia TC, et al. Detection of coronary artery lesions and myocardial necrosis by magnetic resonance in systemic necrotizing vasculitides. Arthritis Rheum. 2009;61:1121. DOI: https://doi.org/10.1002/art.24695
  14. De Cobelli F, Pieroni M, Esposito A, Chimenti C, et al. Delayed gadolinium-enhanced cardiac magnetic resonance inpatients with chronic myocarditis presenting with heart failure or recurrent arrhythmias. J Am Coll Cardiol. 2006;47(8):1649–54. DOI: https://doi.org/10.1016/j.jacc.2005.11.067
  15. Jen Li Looi, Peter Ruygrok, Gordon Royle, et al. Acute eosinophilic endomyocarditis: early diagnosis and localization of the lesion by cardiac magnetic resonance imaging. Int J Cardiovasc Imaging. 2010;26:151–4. DOI: https://doi.org/10.1007/s10554-009-9580-9
  16. Alter P, Maisch B. Endomyocardial fibrosis in Churg-Strauss syndrome assessed by cardiac magnetic resonance imaging. Int J Cardiol. 2006;108:112–3. DOI: https://doi.org/10.1016/j.ijcard.2005.02.019
  17. Hans-Uwe Simon, et al. Refining the definition of hypereosinophilic syndrome. J. Allergy Clin Immunol. Vol.126,1:45–9. DOI: https://doi.org/10.1016/j.jaci.2010.03.042
  18. Vassina EM, Yousefi S, Simon D, Zwicky C, Conus S, Simon HU. cIAP2 and surviving contribute to cytokine-mediated delayed eosinophil apoptosis. Eur J Immunol. 2006;36:1975–84. DOI: https://doi.org/10.1002/eji.200635943
  19. Klion AD, Noel P, Akin C, et al. Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis and imatinib responsiveness. Blood. 2003;101:4660. DOI: https://doi.org/10.1182/blood-2003-01-0006
  20. Desreumaux P, Janin A, Dubucquoi S, et al. Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases. Blood. 1993;82:1553–60. DOI: https://doi.org/10.1182/blood.V82.5.1553.1553
  21. Pagnoux C, Guillevin L. Churg-Strauss syndrome: evidence for disease subtypes? Curr Opin Rheumatol. 2010;22:21. DOI: https://doi.org/10.1097/BOR.0b013e328333390b
  22. Guillevin L, Lhote F, Gayraud M, Cohen P, Jarrousse B, Lortholary O, et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore). 1996;75:17–28. DOI: https://doi.org/10.1097/00005792-199601000-00003
  23. Pitini V, Arrigo C, Azzarello D, La Gattuta G, Amata C, Righi M, et al. Serum concentration of cardiac Troponin T in patients with hypereosinophilic syndrome treated with imatinib is predictive of adverse outcomes. Blood. 2003;102:3456. DOI: https://doi.org/10.1182/blood-2003-07-2393
  24. Zaky J, Caraang C, Yu R, El-Bialy A. Elevated troponins and the Churg-Strauss syndrome: a case report. J Cardiovasc Pharmacol Ther. 2005;10:131. DOI: https://doi.org/10.1177/107424840501000207
  25. Sato Y, Taniguchi R, Yamada T, et al. Measurements of serum concentrations of cardiac troponin T in patients with hypereosinophilic syndrome: a sensitive non-invasive marker of cardiac disorder. Intern Med. 2000;39(4):350. DOI: https://doi.org/10.2169/internalmedicine.39.350

Most read articles by the same author(s)